<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microcirculation</journal-id><journal-title-group><journal-title xml:lang="ru">Регионарное кровообращение и микроциркуляция</journal-title><trans-title-group xml:lang="en"><trans-title>Regional blood circulation and microcirculation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-6655</issn><issn pub-type="epub">2712-9756</issn><publisher><publisher-name>Academician I.P. Pavlov First St. Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1682-6655-2021-20-4-4-13</article-id><article-id custom-type="elpub" pub-id-type="custom">microcirculation-1005</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Системный эндотелиит при новой коронавирусной инфекции COVID-19: гендерные и перинатальные риски</article-title><trans-title-group xml:lang="en"><trans-title>Systemic endotheliitis in terms of novel coronavirus infection COVID-19: gender-related and perinatal risks</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чхаидзе</surname><given-names>И. З.</given-names></name><name name-style="western" xml:lang="en"><surname>Chkhaidze</surname><given-names>I. Z.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чхаидзе Ия Зурабовна – ассистент кафедры акушерства, гинекологии и репродуктологии медицинского факультета</p><p>199034, Санкт-Петербург, Университетская набережная, д. 7/9</p></bio><bio xml:lang="en"><p>Chkhaidze Iya Z. – Assistant of the Department of Obstetrics, Gynecology, and Reproductive Sciences, Medical Faculty</p><p>7/9 Universitetskaya embankment, Saint Petersburg, 199034</p></bio><email xlink:type="simple">chkhaidze_i@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лиознов</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lioznov</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лиознов Дмитрий Анатольевич – д-р мед. наук, профессор, зав. кафедрой инфекционных болезней и эпидемиологии</p><p>197376, Санкт-Петербург, ул. профессора Попова, д. 15/17</p></bio><bio xml:lang="en"><p>Lioznov Dmitry A. – Doctor of Medical Sciences, Professor, Head of the Department of Infectious Diseases and Epidemiology</p><p>15/17, Professora Popova str., Petersburg, 197376</p></bio><email xlink:type="simple">dlioznov@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрищев</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrishchev</surname><given-names>N . N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петрищев Николай Николаевич – д-р мед. наук, профессор, заслуженный деятель науки РФ, профессор кафедры патофизиологии с курсом клинической патофизиологии, руководитель Центра лазерной медицины</p><p>197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8</p></bio><bio xml:lang="en"><p>Petrishchev Nikolay N. – Doctor of Medical Sciences, Professor, Honored Scientist of the Russian Federation, Professor of the Department of Pathophysiology with the course of clinical pathophysiology, Head of the Center for Laser Medicine; Head of the Russian Association for Regional Hemodynamics and Microcirculation</p><p>6-8, L’va Tolstogo street, Saint Petersburg, 197022</p></bio><email xlink:type="simple">lazmed@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ниаури</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Niauri</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ниаури Дарико Александровна – д-р мед. наук, профессор, зав. кафедрой акушерства, гинекологии и репродуктологии медицинского факультета</p><p>199034, Санкт-Петербург, Университетская набережная, д. 7/9</p></bio><bio xml:lang="en"><p>Niauri Dariko A. – Doctor of Medical Sciences, Professor, Head of the Department of Obstetrics, Gynecology, and Reproductive Sciences, Medical Faculty</p><p>7/9 Universitetskaya embankment, Saint Petersburg, 199034</p></bio><email xlink:type="simple">d.niauri@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint-Petersburg State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Научно-исследовательский институт гриппа имени А. А. Смородинцева» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>WHO-Recognized National Influenza Centre (NIC), Smorodintsev Research Institute of Influenza</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pavlov University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>09</day><month>01</month><year>2022</year></pub-date><volume>20</volume><issue>4</issue><fpage>4</fpage><lpage>13</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чхаидзе И.З., Лиознов Д.А., Петрищев Н.Н., Ниаури Д.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Чхаидзе И.З., Лиознов Д.А., Петрищев Н.Н., Ниаури Д.А.</copyright-holder><copyright-holder xml:lang="en">Chkhaidze I.Z., Lioznov D.A., Petrishchev N.N., Niauri D.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.microcirc.ru/jour/article/view/1005">https://www.microcirc.ru/jour/article/view/1005</self-uri><abstract><p>В обзоре рассмотрены некоторые физиологические особенности, отражающие гендерные различия в подверженности новой коронавирусной инфекции. Представлена актуальная информация о влиянии COVID-19 на течение беременности, перинатальные исходы. Освещены дискуссионные вопросы возможности вертикальной передачи вируса SARS-CoV-2 на основании анализа доступных литературных данных, рекомендаций международных профессиональных сообществ.</p></abstract><trans-abstract xml:lang="en"><p>The review considers some physiological features that reflect gender differences in the susceptibility to a novel coronavirus infection. Up-to-date information on the impact of COVID-19 on the course of pregnancy and perinatal outcomes is presented. The debatable issues of the possibility of vertical transmission of the SARS-CoV-2 virus are highlighted based on the analysis of available literature data and recommendations of international professional communities.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>вирус SARS-CoV-2</kwd><kwd>коронавирусная инфекция</kwd><kwd>эндотелиит</kwd><kwd>беременность</kwd><kwd>роды</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>SARS-CoV-2 virus</kwd><kwd>coronavirus infection</kwd><kwd>endotheliitis</kwd><kwd>pregnancy</kwd><kwd>childbirth</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">WHO Coronavirus (COVID-19) Dashboard. URL: https://covid19.who.int/ (дата обращения: 15.08.2021).</mixed-citation><mixed-citation xml:lang="en">WHO Coronavirus (COVID-19) Dashboard. Available at: https://covid19.who.int/ (accessed: 15.08.2021).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Xu X, Chen P, Wang J, Feng J, Zhou H, Li X, Zhong W, Hao P. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission // Sci China Life Sci. 2020;63(3):457–460. Doi: 10.1007/s11427-020-1637-5.</mixed-citation><mixed-citation xml:lang="en">Xu X, Chen P, Wang J, Feng J, Zhou H, Li X, Zhong W, Hao P. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission // Sci China Life Sci. 2020;63(3):457–460. Doi: 10.1007/s11427-020-1637-5.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W, Duan G. Virology, Epidemiology, Pathogenesis, and Control of COVID-19 // Viruses. 2020;12(4):372. Doi: 10.3390/v12040372.</mixed-citation><mixed-citation xml:lang="en">Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W, Duan G. Virology, Epidemiology, Pathogenesis, and Control of COVID-19 // Viruses. 2020;12(4):372. Doi: 10.3390/v12040372.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Lin L, Lu L, Cao W, Li T. Hypothesis for potential pathogenesis of SARS-CoV-2 infection - a review of immune changes in patients with viral pneumonia // Emerg Microbes Infect. 2020;9(1):727–732. Doi: 10.1080/22221751.2020.1746199.</mixed-citation><mixed-citation xml:lang="en">Lin L, Lu L, Cao W, Li T. Hypothesis for potential pathogenesis of SARS-CoV-2 infection - a review of immune changes in patients with viral pneumonia // Emerg Microbes Infect. 2020;9(1):727–732. Doi: 10.1080/22221751.2020.1746199.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Alenina N, Bader M. ACE2 in Brain Physiology and Pathophysiology: Evidence from Transgenic Animal Models // Neurochem Res. 2019;44(6):1323–1329. Doi: 10.1007/s11064-018-2679-4.</mixed-citation><mixed-citation xml:lang="en">Alenina N, Bader M. ACE2 in Brain Physiology and Pathophysiology: Evidence from Transgenic Animal Models // Neurochem Res. 2019;44(6):1323–1329. Doi: 10.1007/s11064-018-2679-4.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kuba K, Imai Y, Penninger JM. Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases // Circ J. 2013;77(2):301–308. Doi: 10.1253/circj.cj-12-1544.</mixed-citation><mixed-citation xml:lang="en">Kuba K, Imai Y, Penninger JM. Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases // Circ J. 2013;77(2):301–308. Doi: 10.1253/circj.cj-12-1544.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Qi F, Qian S, Zhang S, Zhang Z. Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses // Biochem Biophys Res Commun. 2020;526(1):135–140. Doi: 10.1016/j.bbrc.2020.03.044.</mixed-citation><mixed-citation xml:lang="en">Qi F, Qian S, Zhang S, Zhang Z. Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses // Biochem Biophys Res Commun. 2020;526(1):135–140. Doi: 10.1016/j.bbrc.2020.03.044.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study // Lancet. 2020;395(10229):1054–1062. Doi: 10.1016/S0140-6736(20)30566-3.</mixed-citation><mixed-citation xml:lang="en">Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study // Lancet. 2020;395(10229):1054–1062. Doi: 10.1016/S0140-6736(20)30566-3.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hu Y, Sun J, Dai Z, Deng H, Li X, Huang Q, Wu Y, Sun L, Xu Y. Prevalence and severity of corona virus disease 2019 (COVID-19): A systematic review and meta-analysis // J Clin Virol. 2020;(127):104371. Doi: 10.1016/j.jcv.2020.104371.</mixed-citation><mixed-citation xml:lang="en">Hu Y, Sun J, Dai Z, Deng H, Li X, Huang Q, Wu Y, Sun L, Xu Y. Prevalence and severity of corona virus disease 2019 (COVID-19): A systematic review and meta-analysis // J Clin Virol. 2020;(127):104371. Doi: 10.1016/j.jcv.2020.104371.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Li B, Yang J, Zhao F, Zhi L, Wang X, Liu L, Bi Z, Zhao Y. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China // Clin Res Cardiol. 2020;109(5):531–538. Doi: 10.1007/s00392-020-01626-9.</mixed-citation><mixed-citation xml:lang="en">Li B, Yang J, Zhao F, Zhi L, Wang X, Liu L, Bi Z, Zhao Y. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China // Clin Res Cardiol. 2020;109(5):531–538. Doi: 10.1007/s00392-020-01626-9.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Коростовцева Л. С., Ротарь О. П., Конради А. О. COVID-19: каковы риски пациентов с артериальной гипертензией? // Артериальная гипертензия. – 2020. – № 26(2). – С. 124–132.</mixed-citation><mixed-citation xml:lang="en">Korostovtseva LS, Rotar OP, Konradi AO. COVID 19: what are the risks in hypertensive patients? // Arterial’naya Gipertenziya = Arterial Hypertension. 2020;26(2):124–132. (In Russ.). Doi: 10.18705/1607-419X-2020-26-2-124-132.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Giannis D, Ziogas IA, Gianni P. Coagulation disorders in coronavirus infected patients: COVID-19, SARSCoV-1, MERS-CoV and lessons from the past // J Clin Virol. 2020;(127):104362. Doi: 10.1016/j.jcv.2020.104362.</mixed-citation><mixed-citation xml:lang="en">Giannis D, Ziogas IA, Gianni P. Coagulation disorders in coronavirus infected patients: COVID-19, SARSCoV-1, MERS-CoV and lessons from the past // J Clin Virol. 2020;(127):104362. Doi: 10.1016/j.jcv.2020.104362.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Han H, Yang L, Liu R, Liu F, Wu K-L, Li J, Liu X-H, Zhu C-L. Prominent changes in blood coagulation of patients with SARS-CoV-2 infection // Clin Chem Lab Med. 2020;58(7):1116–1120. Doi: 10.1515/cclm-2020-0188.</mixed-citation><mixed-citation xml:lang="en">Han H, Yang L, Liu R, Liu F, Wu K-L, Li J, Liu X-H, Zhu C-L. Prominent changes in blood coagulation of patients with SARS-CoV-2 infection // Clin Chem Lab Med. 2020;58(7):1116–1120. Doi: 10.1515/cclm-2020-0188.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Levi M. COVID-19 coagulopathy vs disseminated intravascular coagulation // Blood Adv. 2020;4(12):2850. Doi: 10.1182/bloodadvances.2020002197.</mixed-citation><mixed-citation xml:lang="en">Levi M. COVID-19 coagulopathy vs disseminated intravascular coagulation // Blood Adv. 2020;4(12):2850. Doi: 10.1182/bloodadvances.2020002197.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy // J Thromb Haemost. 2020;18(5):1094–1099. Doi: 10.1111/jth.14817.</mixed-citation><mixed-citation xml:lang="en">Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy // J Thromb Haemost. 2020;18(5):1094–1099. Doi: 10.1111/jth.14817.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Lillicrap D. Disseminated intravascular coagulation in patients with 2019-nCoV pneumonia // J Thromb Haemost. 2020;18(4):786–787. Doi: 10.1111/jth.14781.</mixed-citation><mixed-citation xml:lang="en">Lillicrap D. Disseminated intravascular coagulation in patients with 2019-nCoV pneumonia // J Thromb Haemost. 2020;18(4):786–787. Doi: 10.1111/jth.14781.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Pons S, Fodil S, Azoulay E, Zafrani L. The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection // Crit Care. 2020;24(1):353. Doi: 10.1186/s13054-020-03062-7.</mixed-citation><mixed-citation xml:lang="en">Pons S, Fodil S, Azoulay E, Zafrani L. The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection // Crit Care. 2020;24(1):353. Doi: 10.1186/s13054-020-03062-7.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Monteil V, Kwon H, Prado P, Hagelkrüys A, Wimmer RA, Stahl M, Leopoldi A, Garreta E, Del Pozo CH, Prosper F, Romero JP, Wirnsberger G, Zhang H, Slutsky AS, Conder R, Montserrat N, Mirazimi A, Penninger JM. Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2 // Cell. 2020;181(4):905–913.e7. Doi: 10.1016/j.cell.2020.04.004.</mixed-citation><mixed-citation xml:lang="en">Monteil V, Kwon H, Prado P, Hagelkrüys A, Wimmer RA, Stahl M, Leopoldi A, Garreta E, Del Pozo CH, Prosper F, Romero JP, Wirnsberger G, Zhang H, Slutsky AS, Conder R, Montserrat N, Mirazimi A, Penninger JM. Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2 // Cell. 2020;181(4):905–913.e7. Doi: 10.1016/j.cell.2020.04.004.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Varga Z, Flammer AJ, Steiger P, Haberecker M, AnderMatt R, Zinkernagel AS, Mehra MR, Schuepbach RA, Ruschitzka F, Moch H. Endothelial cell infection and endotheliitis in COVID-19 // The Lancet. 2020;395(10234):1417–1418. Doi: 10.1016/S0140-6736(20)30937-5.</mixed-citation><mixed-citation xml:lang="en">Varga Z, Flammer AJ, Steiger P, Haberecker M, AnderMatt R, Zinkernagel AS, Mehra MR, Schuepbach RA, Ruschitzka F, Moch H. Endothelial cell infection and endotheliitis in COVID-19 // The Lancet. 2020;395(10234):1417–1418. Doi: 10.1016/S0140-6736(20)30937-5.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A, Li WW, Li VW, Mentzer SJ, Jonigk D. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 // N Engl J Med. 2020;383(2):120–128. Doi: 10.1056/NEJMoa2015432.</mixed-citation><mixed-citation xml:lang="en">Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A, Li WW, Li VW, Mentzer SJ, Jonigk D. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 // N Engl J Med. 2020;383(2):120–128. Doi: 10.1056/NEJMoa2015432.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in china: summary of a report of 72314 cases from the Chinese center for disease control and prevention // JAMA – J Am Med Assoc. 2020;(323):1239–1242. Doi: 10.1001/jama.2020.2648.</mixed-citation><mixed-citation xml:lang="en">Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in china: summary of a report of 72314 cases from the Chinese center for disease control and prevention // JAMA – J Am Med Assoc. 2020;(323):1239–1242. Doi: 10.1001/jama.2020.2648.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Lara PC, Macías-Verde D, Burgos-Burgos J. Age-induced NLRP3 Inflammasome Over-activation Increases Lethality of SARS-CoV-2 Pneumonia in Elderly Patients // Aging Dis. 2020;11(4):756–762. Doi: 10.14336/AD.2020.0601.</mixed-citation><mixed-citation xml:lang="en">Lara PC, Macías-Verde D, Burgos-Burgos J. Age-induced NLRP3 Inflammasome Over-activation Increases Lethality of SARS-CoV-2 Pneumonia in Elderly Patients // Aging Dis. 2020;11(4):756–762. Doi: 10.14336/AD.2020.0601.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Основы иммунореабилитации при новой корона-вирусной инфекции (COVID-19): пособие для врачей / под ред. М. П. Костинова. – М.: Группа МДВ, 2020. – C. 112.</mixed-citation><mixed-citation xml:lang="en">Osnovy immunoreabilitacii pri novoj koronavirusnoj infekcii (COVID-19): posobie dlya vrachej / pod red. M. P. Kostinova. Moscow, Gruppa MDV, 2020:112. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Scully EP, Haverfield J, Ursin RL, Tannenbaum C, Klein SL. Considering how biological sex impacts immune responses and COVID-19 outcomes // Nat Rev Immunol. 2020;20(7):442–447. Doi: 10.1038/s41577-020-0348-8.</mixed-citation><mixed-citation xml:lang="en">Scully EP, Haverfield J, Ursin RL, Tannenbaum C, Klein SL. Considering how biological sex impacts immune responses and COVID-19 outcomes // Nat Rev Immunol. 2020;20(7):442–447. Doi: 10.1038/s41577-020-0348-8.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Guan WJ, Ni Z-Y, Hu Y, Liang WH, Ou C-Q, He J-X, Liu L, Shan H, Lei C-L, Hui DSC, Du B, Li L-J, Zeng G, Yuen K-Y, Chen R-C, Tang C-L, Wang T, Chen P-Y, Xiang J, Li S-Y, Wang J-L, Liang Z-J, Peng Y-X, Wei L, Liu Y, Hu Y-H, Peng P, Wang J-M, Liu J-Y, Chen Z, Li G, Zheng Z-J, Qiu S-Q, Luo J, Ye C-J, Zhu S-Y, Zhong N-S. Clinical Characteristics of Coronavirus Disease 2019 in China // N Engl J Med. 2020;382(18):1708–1720. Doi: 10.1056/NEJMoa2002032.</mixed-citation><mixed-citation xml:lang="en">Guan WJ, Ni Z-Y, Hu Y, Liang WH, Ou C-Q, He J-X, Liu L, Shan H, Lei C-L, Hui DSC, Du B, Li L-J, Zeng G, Yuen K-Y, Chen R-C, Tang C-L, Wang T, Chen P-Y, Xiang J, Li S-Y, Wang J-L, Liang Z-J, Peng Y-X, Wei L, Liu Y, Hu Y-H, Peng P, Wang J-M, Liu J-Y, Chen Z, Li G, Zheng Z-J, Qiu S-Q, Luo J, Ye C-J, Zhu S-Y, Zhong N-S. Clinical Characteristics of Coronavirus Disease 2019 in China // N Engl J Med. 2020;382(18):1708–1720. Doi: 10.1056/NEJMoa2002032.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, Norman L, Holden KA, Read JM, Dondelinger F, Carson G, Merson L, Lee J, Plotkin D, Sigfrid L, Halpin S, Jackson C, Gamble C, Horby PW, Nguyen-Van-Tam JS, Ho A, Russell CD, Dunning J, Openshaw PJm, Baillie JK. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study // BMJ. 2020;(369):1985. Doi: 10.1136/bmj.m1985.</mixed-citation><mixed-citation xml:lang="en">Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, Norman L, Holden KA, Read JM, Dondelinger F, Carson G, Merson L, Lee J, Plotkin D, Sigfrid L, Halpin S, Jackson C, Gamble C, Horby PW, Nguyen-Van-Tam JS, Ho A, Russell CD, Dunning J, Openshaw PJm, Baillie JK. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study // BMJ. 2020;(369):1985. Doi: 10.1136/bmj.m1985.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Sun P, Lu X, Xu C, Sun W, Pan B. Understanding of COVID-19 based on current evidence // J Med Virol. 2020;92(6):548–551. Doi: 10.1002/jmv.25722.</mixed-citation><mixed-citation xml:lang="en">Sun P, Lu X, Xu C, Sun W, Pan B. Understanding of COVID-19 based on current evidence // J Med Virol. 2020;92(6):548–551. Doi: 10.1002/jmv.25722.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Li MY, Li L, Zhang Y, Wang XS. Expression of the SARSCoV-2 cell receptor gene ACE2 in a wide variety of human tissues // Infect. Dis. Poverty. 2020:9(1):45. Doi: 10.1186/s40249-020-00662-x.</mixed-citation><mixed-citation xml:lang="en">Li MY, Li L, Zhang Y, Wang XS. Expression of the SARSCoV-2 cell receptor gene ACE2 in a wide variety of human tissues // Infect. Dis. Poverty. 2020:9(1):45. Doi: 10.1186/s40249-020-00662-x.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Rossouw JE, Prentice RL, Manson JE, Wu L, Barad D, Barnabei VM, Ko M, LaCroix AZ, Margolis KL, Stefanick ML. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause // JAMA 2007;297(13):1465–1477. Doi: 10.1001/jama.297.13.1465.</mixed-citation><mixed-citation xml:lang="en">Rossouw JE, Prentice RL, Manson JE, Wu L, Barad D, Barnabei VM, Ko M, LaCroix AZ, Margolis KL, Stefanick ML. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause // JAMA 2007;297(13):1465–1477. Doi: 10.1001/jama.297.13.1465.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Miller VM, Duckles SP. Vascular Actions of Estrogens: Functional Implications // Pharmacol. Rev. 2008:60(2):210–241. Doi: 10.1124/pr.107.08002.</mixed-citation><mixed-citation xml:lang="en">Miller VM, Duckles SP. Vascular Actions of Estrogens: Functional Implications // Pharmacol. Rev. 2008:60(2):210–241. Doi: 10.1124/pr.107.08002.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Koh KK. Effects of estrogen on the vascular wall: vasomotor function and inflammation // Cardiovasc. Res. 2002: 55(4):714–726. Doi: 10.1016/s0008-6363(02)00487-x.</mixed-citation><mixed-citation xml:lang="en">Koh KK. Effects of estrogen on the vascular wall: vasomotor function and inflammation // Cardiovasc. Res. 2002: 55(4):714–726. Doi: 10.1016/s0008-6363(02)00487-x.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Aroor AR, DeMarco VG, Jia G, Sun Z, Nistala R, Meininger GA, Sowers JR. The role of tissue reninangiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness // Front. Endocrinol. (Lausanne). 2013:(4):161. Doi: 10.3389/fendo.2013.00161.</mixed-citation><mixed-citation xml:lang="en">Aroor AR, DeMarco VG, Jia G, Sun Z, Nistala R, Meininger GA, Sowers JR. The role of tissue reninangiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness // Front. Endocrinol. (Lausanne). 2013:(4):161. Doi: 10.3389/fendo.2013.00161.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Gohar EY, Pollock DM. Sex-specific contributions of endothelin to hypertension // Curr Hypertens Rep. 2018; 20(7):58. Doi: 10.1007/s11906-018-0856-0.</mixed-citation><mixed-citation xml:lang="en">Gohar EY, Pollock DM. Sex-specific contributions of endothelin to hypertension // Curr Hypertens Rep. 2018; 20(7):58. Doi: 10.1007/s11906-018-0856-0.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Campelo AE, Cutini PH, Massheimer VL. Cellular actions of testosterone in vascular cells: mechanism independent of aromatization to estradiol // Steroids. 2012: 77(11):1033–1040. Doi: 10.1016/j.steroids.2012.05.008.</mixed-citation><mixed-citation xml:lang="en">Campelo AE, Cutini PH, Massheimer VL. Cellular actions of testosterone in vascular cells: mechanism independent of aromatization to estradiol // Steroids. 2012: 77(11):1033–1040. Doi: 10.1016/j.steroids.2012.05.008.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">White RE, Han G, Maunz M, Dimitropoulou C, El-Mowafy AM, Barlow RS, Catravas JD. Snead C, Carrier GO, Zhu S, Yu X. Endothelium-independent effect of estrogen on Ca (2+)-activated K (+) channels in human coronary artery smooth muscle cells // Cardiovasc. Res. 2002:53(3):650–661. Doi: 10.1016/s0008-6363(01)00428-x.</mixed-citation><mixed-citation xml:lang="en">White RE, Han G, Maunz M, Dimitropoulou C, El-Mowafy AM, Barlow RS, Catravas JD. Snead C, Carrier GO, Zhu S, Yu X. Endothelium-independent effect of estrogen on Ca (2+)-activated K (+) channels in human coronary artery smooth muscle cells // Cardiovasc. Res. 2002:53(3):650–661. Doi: 10.1016/s0008-6363(01)00428-x.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Wastnedge EAN, Reynolds RM, van Boeckel SR, Stock SJ. Denison FC, Maybin JA, Critchley HOD. Pregnancy and COVID-19 // Physiol Reviews. 2021;101(1):303–318. Doi: 10.1152/physrev.00024.2020.</mixed-citation><mixed-citation xml:lang="en">Wastnedge EAN, Reynolds RM, van Boeckel SR, Stock SJ. Denison FC, Maybin JA, Critchley HOD. Pregnancy and COVID-19 // Physiol Reviews. 2021;101(1):303–318. Doi: 10.1152/physrev.00024.2020.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Alghamdi IG., Hussain II, Almalki SS, Alghamdi MS, Alghamdi MM, El-Sheemy MA. The pattern of Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive epidemiological analysis of data from the Saudi Ministry of Health // Int J Gen Med. 2014;(7):417–423. Doi: 10.2147/IJGM.S67061.</mixed-citation><mixed-citation xml:lang="en">Alghamdi IG., Hussain II, Almalki SS, Alghamdi MS, Alghamdi MM, El-Sheemy MA. The pattern of Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive epidemiological analysis of data from the Saudi Ministry of Health // Int J Gen Med. 2014;(7):417–423. Doi: 10.2147/IJGM.S67061.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Klein SL, Jedlicka A, Pekosz A. The Xs and Y of immune responses to viral vaccines. Lancet Infect Dis. 2010;10(5):338–349. Doi: 10.1016/S1473-3099(10)70049-9.</mixed-citation><mixed-citation xml:lang="en">Klein SL, Jedlicka A, Pekosz A. The Xs and Y of immune responses to viral vaccines. Lancet Infect Dis. 2010;10(5):338–349. Doi: 10.1016/S1473-3099(10)70049-9.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Klein SL, Flanagan KL. Sex differences in immune responses // Nat Rev Immunol. 2016;16(10):626–638. Doi: 10.1038/nri.2016.90.</mixed-citation><mixed-citation xml:lang="en">Klein SL, Flanagan KL. Sex differences in immune responses // Nat Rev Immunol. 2016;16(10):626–638. Doi: 10.1038/nri.2016.90.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Mauvais-Jarvis F, Klein SL, Levin ER. Estradiol, Progesterone, Immunomodulation, and COVID-19 Outcomes // Endocrinology. 2020;161(9):127. Doi: 10.1210/endocr/bqaa127.</mixed-citation><mixed-citation xml:lang="en">Mauvais-Jarvis F, Klein SL, Levin ER. Estradiol, Progesterone, Immunomodulation, and COVID-19 Outcomes // Endocrinology. 2020;161(9):127. Doi: 10.1210/endocr/bqaa127.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Doria A, Iaccarino L, Arienti S, Ghirardello A. Zampieri S, Rampudda ME, Cutolo M, Tincani A, Todesco S. Th2 immune deviation induced by pregnancy: the two faces of autoimmune rheumatic diseases // Reprod Toxicol. 2006;22(2):234–241. Doi: 10.1016/j.reprotox.2006.04.001.</mixed-citation><mixed-citation xml:lang="en">Doria A, Iaccarino L, Arienti S, Ghirardello A. Zampieri S, Rampudda ME, Cutolo M, Tincani A, Todesco S. Th2 immune deviation induced by pregnancy: the two faces of autoimmune rheumatic diseases // Reprod Toxicol. 2006;22(2):234–241. Doi: 10.1016/j.reprotox.2006.04.001.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, Ren R, Leung KSM, Lau EHY, Wong JY, Xing X, Xiang N, Wu Y, Li C, Chen Q, Li D, Liu T, Zhao J, Liu M, Tu W, Chen C, Jin L, Yang R, Wang Q, Zhou S, Wang R, Liu H, Yinbo L, Liu Y, Shao G, Li H, Tao Z, Yang Y, Deng Z, Liu B, Ma Z, Zhang Y, Shi G, Lam TTY, Wu JT, Gao GF, Cowling BJ, Yang B, Leung GM, Feng Z. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia // N Engl J Med. 2020;382(13):1199–1207. Doi: 10.1056/NEJMoa2001316NEJMoa2001316.</mixed-citation><mixed-citation xml:lang="en">Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, Ren R, Leung KSM, Lau EHY, Wong JY, Xing X, Xiang N, Wu Y, Li C, Chen Q, Li D, Liu T, Zhao J, Liu M, Tu W, Chen C, Jin L, Yang R, Wang Q, Zhou S, Wang R, Liu H, Yinbo L, Liu Y, Shao G, Li H, Tao Z, Yang Y, Deng Z, Liu B, Ma Z, Zhang Y, Shi G, Lam TTY, Wu JT, Gao GF, Cowling BJ, Yang B, Leung GM, Feng Z. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia // N Engl J Med. 2020;382(13):1199–1207. Doi: 10.1056/NEJMoa2001316NEJMoa2001316.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Адамян Л. В., Вечорко В. И., Конышева О. В., Харченко Э. И. Беременность и COVID-19: актуальные вопросы (обзор литературы) // Проблемы репродукции. – 2021. – Т. 27, № 3. – С.70–77.</mixed-citation><mixed-citation xml:lang="en">Adamyan LV, Vechorko VI, Konysheva OV, Kharchenko EI. Pregnancy and COVID-19: current issues (literature review) // Problemy Reproduktsii = Russian Journal of Human Reproduction. 2021;27(3):70–77. (In Russ.). Doi: 10.17116/repro20212703170.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Pazos M, Sperling RS, Moran TM, Kraus TA. The influence of pregnancy on systemic immunity // Immunol Res. 2012;54(1–3):254–261. Doi: 10.1007/s12026-012-8303-9.</mixed-citation><mixed-citation xml:lang="en">Pazos M, Sperling RS, Moran TM, Kraus TA. The influence of pregnancy on systemic immunity // Immunol Res. 2012;54(1–3):254–261. Doi: 10.1007/s12026-012-8303-9.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Straub RH. The complex role of estrogens in inflammation // Endocr Rev. 2007;28(5):521–574. Doi: 10.1210/er.2007-0001.</mixed-citation><mixed-citation xml:lang="en">Straub RH. The complex role of estrogens in inflammation // Endocr Rev. 2007;28(5):521–574. Doi: 10.1210/er.2007-0001.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Robinson DP, Klein SL. Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis // Horm Behav. 2012;62(3):263–271. Doi: 10.1016/j.yhbeh.2012.02.023.</mixed-citation><mixed-citation xml:lang="en">Robinson DP, Klein SL. Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis // Horm Behav. 2012;62(3):263–271. Doi: 10.1016/j.yhbeh.2012.02.023.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Szekeres-Bartho J, Šućurović S, Mulac-Jeričević B. The Role of Extracellular Vesicles and PIBF in Embryo-Maternal Immune-Interactions // Front Immunol. 2018;(9):2890. Doi: 10.3389/fimmu.2018.02890.</mixed-citation><mixed-citation xml:lang="en">Szekeres-Bartho J, Šućurović S, Mulac-Jeričević B. The Role of Extracellular Vesicles and PIBF in Embryo-Maternal Immune-Interactions // Front Immunol. 2018;(9):2890. Doi: 10.3389/fimmu.2018.02890.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Сидельникова В. М. Невынашивание беременности – современный взгляд на проблему // Рос. вестн. акушера-гинеколога. – 2007. – Т. 7, № 2. – С. 62–64.</mixed-citation><mixed-citation xml:lang="en">Sidelnikova VM. Miscarriage: the present view of the problem // Rossiiskii vestnik akushera-ginekologa = Russian Bulletin of Obstetriciangynaecologist. 2007;7(2):62–64. (In Russ.). eLIBRARY ID: 9512676.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, Wang T, Zhang X, Chen H, Yu H, Zhang X, Zhang M, Wu S, Song J, Chen T, Han M, Li S, Luo X, Jianping Z, Ning Q. Clinical and immunological features of severe and moderate coronavirus disease 2019 // J Clin Invest. 2020:130(5):2620–2629. Doi: 10.1172/JCI137244.</mixed-citation><mixed-citation xml:lang="en">Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, Wang T, Zhang X, Chen H, Yu H, Zhang X, Zhang M, Wu S, Song J, Chen T, Han M, Li S, Luo X, Jianping Z, Ning Q. Clinical and immunological features of severe and moderate coronavirus disease 2019 // J Clin Invest. 2020:130(5):2620–2629. Doi: 10.1172/JCI137244.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Orrù B, Szekeres-Bartho J, Bizzarri M, Spiga AM, Unfer V. Inhibitory effects of Vitamin D on inflammation and IL-6 release. A further support for COVID-19 management? // Eur Rev Med Pharmacol Sci. 2020:24(15):8187–8193. Doi: 10.26355/eurrev_202008_22507.</mixed-citation><mixed-citation xml:lang="en">Orrù B, Szekeres-Bartho J, Bizzarri M, Spiga AM, Unfer V. Inhibitory effects of Vitamin D on inflammation and IL-6 release. A further support for COVID-19 management? // Eur Rev Med Pharmacol Sci. 2020:24(15):8187–8193. Doi: 10.26355/eurrev_202008_22507.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Организация оказания медицинской помощи беременным, роженицам, родильницам и новорожденным при новой коронавирусной инфекции COVID-19». Версия 4: метод. рекомендации / Министерство здравоохранения Российской Федерации. 05.07.2021. URL: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/057/333/original/05072021_MR_Preg_v4.pdf (дата обращения: 13.08.2021).</mixed-citation><mixed-citation xml:lang="en">Organizaciya okazaniya medicinskoj pomoshchi beremennym, rozhenicam, rodil’nicam i novorozhdennym pri novoj koronavirusnoj infekcii COVID-19». Versiya 4: metod. rekomendacii / Ministerstvo zdravoohraneniya Rossijskoj Federacii. 05.07.2021. Available at: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/057/333/original/05072021_MR_Preg_v4.pdf (accessed: 13.08.2021).</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Liu D, Li L, Wu Х, Zheng D. Wang J, Yang L, Zheng C. Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis // AJR Am J Roentgenol. 2020:215(1):127–132. Doi: 10.2214/AJR.20.23072.</mixed-citation><mixed-citation xml:lang="en">Liu D, Li L, Wu Х, Zheng D. Wang J, Yang L, Zheng C. Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis // AJR Am J Roentgenol. 2020:215(1):127–132. Doi: 10.2214/AJR.20.23072.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Coronavirus (COVID-19) Infection in Pregnancy. Version 13 // Royal College of Obstetricians and Gynaecologists. 19 Febr. 2021. 98 p. Available at: https://www.rcog.org.uk/globalassets/documents/guidelines/2021-02-19-coronavirus-covid-19-infection-in-pregnancy-v13.pdf (accessed: 14.08.2021).</mixed-citation><mixed-citation xml:lang="en">Coronavirus (COVID-19) Infection in Pregnancy. Version 13 // Royal College of Obstetricians and Gynaecologists. 19 Febr. 2021. 98 p. Available at: https://www.rcog.org.uk/globalassets/documents/guidelines/2021-02-19-coronavirus-covid-19-infection-in-pregnancy-v13.pdf (accessed: 14.08.2021).</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Knight M, Bunch K, Vousden N, Morris E, Simpson N, Gale C, O’Brien P, Quigley M, Brocklehurst P, Kurinczuk JJ. Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study // BMJ 2020:369:m2107. Doi: 10.1136/bmj.m2107.</mixed-citation><mixed-citation xml:lang="en">Knight M, Bunch K, Vousden N, Morris E, Simpson N, Gale C, O’Brien P, Quigley M, Brocklehurst P, Kurinczuk JJ. Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study // BMJ 2020:369:m2107. Doi: 10.1136/bmj.m2107.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Centers for Disease Control and Prevention. Pregnancy and breast-feeding. Available at: https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/pregnancybreast-feeding.html (accessed: 13.08.2021).</mixed-citation><mixed-citation xml:lang="en">Centers for Disease Control and Prevention. Pregnancy and breast-feeding. Available at: https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/pregnancybreast-feeding.html (accessed: 13.08.2021).</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Collin J, Byström E, Carnahan A, Ahrne M. Public Health Agency of Sweden’s Brief Report: Pregnant and postpartum women with SARS-CoV-2 infection in intensive care in Sweden // Acta Obstet Gynecol Scand. 2020:99(7):819–822. Doi: 10.1111/aogs.13901.</mixed-citation><mixed-citation xml:lang="en">Collin J, Byström E, Carnahan A, Ahrne M. Public Health Agency of Sweden’s Brief Report: Pregnant and postpartum women with SARS-CoV-2 infection in intensive care in Sweden // Acta Obstet Gynecol Scand. 2020:99(7):819–822. Doi: 10.1111/aogs.13901.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Jering KS, Claggett BL, Cunningham JW, Rosenthal N, Vardeny O, Greene MF, Solomon SD. Clinical Characteristics and Outcomes of Hospitalized Women Giving Birth With and Without COVID-19 // JAMA Intern Med. 2021:181(5):714–717. Doi: 10.1001/jamainternmed.2020.9241.</mixed-citation><mixed-citation xml:lang="en">Jering KS, Claggett BL, Cunningham JW, Rosenthal N, Vardeny O, Greene MF, Solomon SD. Clinical Characteristics and Outcomes of Hospitalized Women Giving Birth With and Without COVID-19 // JAMA Intern Med. 2021:181(5):714–717. Doi: 10.1001/jamainternmed.2020.9241.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Белокриницкая Т. Е., Артымук Н. В., Филиппов О. С., Шифман Е. М. Динамика эпидемического процесса и течение новой коронавирусной инфекции COVID-19 у беременных Дальневосточного и Сибирского федеральных округов // Гинекология. – 2020. – Т. 22, № 5. – С. 6–11.</mixed-citation><mixed-citation xml:lang="en">Belokrinitskaya T.E., Artymuk N.V., Filippov O.S., Shifman E.M. Dynamics of the epidemic process and the course of the COVID-19 in pregnant women of the Far Eastern and Siberian Federal Districts // Gynecology. 2020;22(5):6–11. (In Russ.). Doi: 10.26442/20795696.2020.5.200439.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Белокриницкая Т. Е., Артымук Н. В., Филиппов О. С., Фролова Н. И. Клиническое течение, материнские и перинатальные исходы новой коронавирусной инфекции COVID-19 у беременных Сибири и Дальнего Востока // Акушерство и гинекология. – 2021. – № 2. – С. 48–54.</mixed-citation><mixed-citation xml:lang="en">Belokrinitskaya TE, Artymuk NV, Filippov OS, Frolova NI. Clinical course, maternal and perinatal outcomes of 2019 novel coronavirus infectious disease (COVID-19) in pregnant women in Siberia and Far East // Obstetrics and Gynegology. 2021;(2):48–54. (In Russ.). Doi: 10.18565/aig.2021.2.48-54.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, Li J, Zhao D, Xu D, Gong Q, Liao J, Yang H, Hou W, Zhang Y. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records // Lancet. 2020;395(10226):809–815. Doi: 10.1016/S0140-6736(20)30360-3.</mixed-citation><mixed-citation xml:lang="en">Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, Li J, Zhao D, Xu D, Gong Q, Liao J, Yang H, Hou W, Zhang Y. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records // Lancet. 2020;395(10226):809–815. Doi: 10.1016/S0140-6736(20)30360-3.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Zhu H, Wang L, Fang C, Peng S. Zhang L, Chang G, Xia S, Zhou W. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia // Transl Pediatr. 2020;9(1):51–60. Doi: 10.21037/tp.2020.02.06.</mixed-citation><mixed-citation xml:lang="en">Zhu H, Wang L, Fang C, Peng S. Zhang L, Chang G, Xia S, Zhou W. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia // Transl Pediatr. 2020;9(1):51–60. Doi: 10.21037/tp.2020.02.06.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang L, Jiang Y, Wei M, Cheng BH, Zhou XC, Li J, Tian JH, Dong L, Hu RH. Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province // Zhonghua Fu Chan Ke Za Zhi. 2020;55(3):166–171. Doi: 10.3760/cma.j.cn112141-20200218-00111.</mixed-citation><mixed-citation xml:lang="en">Zhang L, Jiang Y, Wei M, Cheng BH, Zhou XC, Li J, Tian JH, Dong L, Hu RH. Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province // Zhonghua Fu Chan Ke Za Zhi. 2020;55(3):166–171. Doi: 10.3760/cma.j.cn112141-20200218-00111.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Elshafeey F, Magdi R, Hindi N, Elshebiny M, Farrag N, Mahdy S, Sabbour M, Gebril S, Nasser M, Kamel M, Amir A, Emara MM, Nabhan A. A systematic scoping review of COVID-19 during pregnancy and childbirth // Int J Gynaecol Obstet. 2020;150(1):47–52. Doi: 10.1002/ijgo.13182.</mixed-citation><mixed-citation xml:lang="en">Elshafeey F, Magdi R, Hindi N, Elshebiny M, Farrag N, Mahdy S, Sabbour M, Gebril S, Nasser M, Kamel M, Amir A, Emara MM, Nabhan A. A systematic scoping review of COVID-19 during pregnancy and childbirth // Int J Gynaecol Obstet. 2020;150(1):47–52. Doi: 10.1002/ijgo.13182.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Zheng QL, Duan T, Jin LP. Single-cell RNA expression profiling of ACE2 and AXL in the human maternal-fetal interface // Reprod Dev Med. 2020;4(1):7–10. Doi: 10.4103/2096-2924.278679.</mixed-citation><mixed-citation xml:lang="en">Zheng QL, Duan T, Jin LP. Single-cell RNA expression profiling of ACE2 and AXL in the human maternal-fetal interface // Reprod Dev Med. 2020;4(1):7–10. Doi: 10.4103/2096-2924.278679.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Diriba K, Awulachew E, Getu E. The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal–fetal transmission: a systematic review and meta-analysis // Eur J Med Res. 2020;25(1):39. Doi: 10.1186/s40001-020-00439-w.</mixed-citation><mixed-citation xml:lang="en">Diriba K, Awulachew E, Getu E. The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal–fetal transmission: a systematic review and meta-analysis // Eur J Med Res. 2020;25(1):39. Doi: 10.1186/s40001-020-00439-w.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Jafari M, Pormohammad A, Sheikh Neshin SA, Ghorbani S, Bose D, Alimohammadi S, Basirjafari S, Mohammadi M, Rasmussen-Ivey C, Razizadeh MH, Nouri-Vaskeh M, Zarei M. Clinical characteristics and outcomes of pregnant women with COVID-19 and comparison with control patients: A systematic review and meta-analysis // Rev Med Virol. 2021:e2208. DOI: 10.1002/rmv.2208.</mixed-citation><mixed-citation xml:lang="en">Jafari M, Pormohammad A, Sheikh Neshin SA, Ghorbani S, Bose D, Alimohammadi S, Basirjafari S, Mohammadi M, Rasmussen-Ivey C, Razizadeh MH, Nouri-Vaskeh M, Zarei M. Clinical characteristics and outcomes of pregnant women with COVID-19 and comparison with control patients: A systematic review and meta-analysis // Rev Med Virol. 2021:e2208. DOI: 10.1002/rmv.2208.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Poon LC, Yang H, Kapur A, Melamed N, Dao B, Divakar H, McIntyre HD, Kihara AB, Ayres-de-Campos D, Ferrazzi EM, Di Renzo GC, Hod M. Global interim guidance on coronavirus disease 2019 (COVID-19) during pregnancy and puerperium from FIGO and allied partners: Information for healthcare professionals // Int J Gynaecol Obstet. 2020;149(3):273–286. Doi: 10.1002/ijgo.13156.</mixed-citation><mixed-citation xml:lang="en">Poon LC, Yang H, Kapur A, Melamed N, Dao B, Divakar H, McIntyre HD, Kihara AB, Ayres-de-Campos D, Ferrazzi EM, Di Renzo GC, Hod M. Global interim guidance on coronavirus disease 2019 (COVID-19) during pregnancy and puerperium from FIGO and allied partners: Information for healthcare professionals // Int J Gynaecol Obstet. 2020;149(3):273–286. Doi: 10.1002/ijgo.13156.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Li M, Chen L, Zhang J, Xiong C, Li X. The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study // PLoS One. 2020;15(4):E0230295. Doi: 10.1371/journal.pone.0230295.</mixed-citation><mixed-citation xml:lang="en">Li M, Chen L, Zhang J, Xiong C, Li X. The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study // PLoS One. 2020;15(4):E0230295. Doi: 10.1371/journal.pone.0230295.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Yale IMPACT Team; Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface // Med (N. Y). 2021;2(5):591–610. Doi: 10.1016/j.medj.2021.04.016.</mixed-citation><mixed-citation xml:lang="en">Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Yale IMPACT Team; Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface // Med (N. Y). 2021;2(5):591–610. Doi: 10.1016/j.medj.2021.04.016.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Hsu AL, Guan M, Johannesen E, Stephens AJ, Khaleel N, Kagan N, Tuhlei BC, Wan X-F. Placental SARSCoV-2 in a pregnant woman with mild COVID-19 disease // J Med Virol. 2021;93(2):1038–1044. Doi: 10.1002/jmv.26386.</mixed-citation><mixed-citation xml:lang="en">Hsu AL, Guan M, Johannesen E, Stephens AJ, Khaleel N, Kagan N, Tuhlei BC, Wan X-F. Placental SARSCoV-2 in a pregnant woman with mild COVID-19 disease // J Med Virol. 2021;93(2):1038–1044. Doi: 10.1002/jmv.26386.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Weatherbee BAT, Glover DM, Zernicka-Goetz M. Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester // Open Biol. 2020:10(8):200162. Doi: 10.1098/rsob.200162.</mixed-citation><mixed-citation xml:lang="en">Weatherbee BAT, Glover DM, Zernicka-Goetz M. Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester // Open Biol. 2020:10(8):200162. Doi: 10.1098/rsob.200162.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Flores-Pliego A, Miranda J, Vega-Torreblanca S, Valdespino-Vázquez Y, Helguera-Repetto C, Espejel-Nuñez A, Borboa-Olivares H, Sosa SEY, Mateu-Rogell P, León-Juárez M, Ramírez-Santes V, Cardona-Pérez A, Villegas-Mota I, Torres-Torres J, Juárez-Reyes Á, Rizo-Pica T, González RO, González-Mariscal L, Estrada-Gutierrez G. Molecular Insights into the Thrombotic and Microvascular Injury in Placental Endothelium of Women with Mild or Severe COVID-19 // Cells. 2021:10(2):364. Doi: 10.3390/cells10020364.</mixed-citation><mixed-citation xml:lang="en">Flores-Pliego A, Miranda J, Vega-Torreblanca S, Valdespino-Vázquez Y, Helguera-Repetto C, Espejel-Nuñez A, Borboa-Olivares H, Sosa SEY, Mateu-Rogell P, León-Juárez M, Ramírez-Santes V, Cardona-Pérez A, Villegas-Mota I, Torres-Torres J, Juárez-Reyes Á, Rizo-Pica T, González RO, González-Mariscal L, Estrada-Gutierrez G. Molecular Insights into the Thrombotic and Microvascular Injury in Placental Endothelium of Women with Mild or Severe COVID-19 // Cells. 2021:10(2):364. Doi: 10.3390/cells10020364.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Bernard I, Limonta D, Mahal LK, Hobman TC. Endothelium Infection and Dysregulation by SARS-CoV-2: Evidence and Caveats in COVID-19 // Viruses. 2020;13(1):29. Doi: 10.3390/v13010029.</mixed-citation><mixed-citation xml:lang="en">Bernard I, Limonta D, Mahal LK, Hobman TC. Endothelium Infection and Dysregulation by SARS-CoV-2: Evidence and Caveats in COVID-19 // Viruses. 2020;13(1):29. Doi: 10.3390/v13010029.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Libby P, Luscher T. COVID-19 is, in the end, an endothelial disease // Eur Heart J. 2020;41(32):3038-3044. Doi: 10.1093/eurheartj/ehaa623.</mixed-citation><mixed-citation xml:lang="en">Libby P, Luscher T. COVID-19 is, in the end, an endothelial disease // Eur Heart J. 2020;41(32):3038-3044. Doi: 10.1093/eurheartj/ehaa623.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Deng H, Tang TX, Chen D, Tang LS, Yang X-P, Tang Z-H. Endothelial Dysfunction and SARS-CoV-2 Infection: Association and Therapeutic Strategies // Pathogens. 2021; 10(5):582. Doi: 10.3390/pathogens10050582.</mixed-citation><mixed-citation xml:lang="en">Deng H, Tang TX, Chen D, Tang LS, Yang X-P, Tang Z-H. Endothelial Dysfunction and SARS-CoV-2 Infection: Association and Therapeutic Strategies // Pathogens. 2021; 10(5):582. Doi: 10.3390/pathogens10050582.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
