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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microcirculation</journal-id><journal-title-group><journal-title xml:lang="ru">Регионарное кровообращение и микроциркуляция</journal-title><trans-title-group xml:lang="en"><trans-title>Regional blood circulation and microcirculation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-6655</issn><issn pub-type="epub">2712-9756</issn><publisher><publisher-name>Academician I.P. Pavlov First St. Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1682-6655-2021-20-4-33-44</article-id><article-id custom-type="elpub" pub-id-type="custom">microcirculation-1008</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ (КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ)</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES (CLINICAL INVESTIGATIONS)</subject></subj-group></article-categories><title-group><article-title>Исследование изменений кожной микроциркуляции крови при выполнении дыхательной техники хатха-йоги</article-title><trans-title-group xml:lang="en"><trans-title>Investigation of changes in the skin blood microcirculation when performing the hatha yoga breathing technique</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фролов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Frolov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фролов Артём Владимирович – ректор</p><p>191186, Санкт-Петербург, Невский пр., д. 30а</p></bio><bio xml:lang="en"><p>Frolov Artem V. – Ltd. St.</p><p>30a, Nevskii pr., Saint Petersburg, 191186</p></bio><email xlink:type="simple">polyclinic@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Локтионова</surname><given-names>Ю. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Loktionova</surname><given-names>Yu. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Локтионова Юлия Игоревна – cтажер-исследователь</p><p>302026, г. Орёл, ул. Комсомольская, д. 95</p></bio><bio xml:lang="en"><p>Loktionova Yulia I. – trainee researcher</p><p>95, Komsomolskaya str., Orel, 302026</p></bio><email xlink:type="simple">julya-loktionova@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жарких</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zharkikh</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жарких Елена Валерьевна – cтажер-исследователь</p><p>302026, г. Орёл, ул. Комсомольская, д. 95</p></bio><bio xml:lang="en"><p>Zharkikh Elena V. – Trainee researcher</p><p>95, Komsomolskaya str., Orel, 302026</p></bio><email xlink:type="simple">ev.zharkikh@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сидоров</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sidorov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сидоров Виктор Васильевич – канд. техн. наук</p><p>123458, Москва, ул. Твардовского, д. 8</p></bio><bio xml:lang="en"><p>Sidorov Victor V. – PhD</p><p>8, Tvardovskogo str., Moscow, 123458</p></bio><email xlink:type="simple">victor.v.sidorov@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крупаткин</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Krupatkin</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Крупаткин Александр Ильич – д-р мед. наук, профессор, ведущий научный сотрудник</p><p>127299, Москва, ул. Приорова, д. 10</p></bio><bio xml:lang="en"><p>Krupatkin Alexandr I. – M. D., professor, Leading researcher</p><p>10, Priorova str., Moscow, 127299</p></bio><email xlink:type="simple">krup.61@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дунаев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dunaev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дунаев Андрей Валерьевич – д-р техн. наук, доцент, ведущий научный сотрудник</p><p>302026, г. Орёл, ул. Комсомольская, д. 95</p></bio><bio xml:lang="en"><p>Dunaev Andrey V. – PhD, associate professor, Leading researcher</p><p>95, Komsomolskaya str., Orel,  302026</p></bio><email xlink:type="simple">inohvat@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Общество с ограниченной ответственностью «Санкт-Петербургский институт восточных методов реабилитации»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ltd. St. Petersburg Institute of Oriental Methods of Rehabilitation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Орловский государственный университет имени И. С. Тургенева»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Orel State University named after I. S. Turgenev</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Oбщество с ограниченной ответственностью «Научно-производственное предприятие "ЛАЗМА"»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>SPE «LAZMA» Ltd.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр травматологии и ортопедии имени Н. Н. Приорова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N. N. Priorov National Medical research center of traumatology and orthopaedics</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>09</day><month>01</month><year>2022</year></pub-date><volume>20</volume><issue>4</issue><fpage>33</fpage><lpage>44</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Фролов А.В., Локтионова Ю.И., Жарких Е.В., Сидоров В.В., Крупаткин А.И., Дунаев А.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Фролов А.В., Локтионова Ю.И., Жарких Е.В., Сидоров В.В., Крупаткин А.И., Дунаев А.В.</copyright-holder><copyright-holder xml:lang="en">Frolov A.V., Loktionova Y.I., Zharkikh E.V., Sidorov V.V., Krupatkin A.I., Dunaev A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.microcirc.ru/jour/article/view/1008">https://www.microcirc.ru/jour/article/view/1008</self-uri><abstract><p>Введение. Дыхательные упражнения йоги способствуют развитию умения значительно снижать частоту дыхания. Уменьшение минутного объема дыхания приводит к компенсаторным реакциям микроциркуляторного русла на изменение газового состава. Оценить реакцию механизмов регуляции микрососудистого русла можно с помощью оптического неинвазивного метода – лазерной допплеровской флоуметрии. Цель исследования заключалась в оценке изменений параметров тканевой микроциркуляции у лиц, выполняющих дыхательные упражнения йоги. Материалы и методы. 25 волонтеров выполняли дыхательные упражнения йоги с частотой 3 раза в минуту, 2 раза в минуту, 1,5 раза в минуту, 1 раз в минуту в течение 5 мин, а также свободное дыхание в течение 6 мин до и после дыхательных упражнений. Для выявления реакции кожной микроциркуляции в разных областях тела человека проводилась одновременная регистрация параметров в шести областях методом лазерной допплеровской флоуметрии с применением распределенной системы носимых анализаторов: показатели микроциркуляции (ПМ), нутритивного кровотока (Мнутр), амплитуд миогенных (Ам), нейрогенных (Ан), эндотелиальных (Аэ), дыхательных (Ад) и сердечных (Ас) осцилляций. Результаты. После выполнения дыхательных упражнений йоги наблюдалось увеличение показателя микроциркуляции при всех частотах дыхания; дыхание с частотой 1,5 и 1/мин приводит к значимому увеличению нутритивного кровотока, что сопровождалось увеличением Ам. Низкочастотные дыхательные упражнения приводят к увеличению Ад при наиболее низких частотах дыхания – 1,5/мин и 1/мин. Наиболее значимые изменения достигнуты при наиболее низких частотах дыхания (1 и 1,5/мин), что может быть связано с гипоксически-гиперкапническими механизмами. Заключение. Отсутствие значительных изменений параметров микрокровотока после низкочастотного дыхания при измерениях в области надглазничных артерий в обеих группах волонтеров характеризует работу гомеостатических механизмов поддержания перфузии мозга в стрессовых для организма ситуациях (низкочастотные типы дыхания, гиперкапния и гипоксия). При измерении в конечностях наблюдалось изменение влияния регуляторных механизмов системы кровообращения, что в совокупности с увеличением кожной перфузии и нутритивной составляющей может характеризовать компенсаторную реакцию микрокровотока на изменение дыхания.</p></abstract><trans-abstract xml:lang="en"><p>Introduction. Yoga breathing exercises improve the ability to significantly reduce the respiratory rate. A decrease of the minute respiration volume results in compensatory reactions of the microcirculatory bed caused by changes in the gas composition. The reaction of the regulatory mechanisms of the microvascular bed can be evaluated by the optical non-invasive laser Doppler flowmetry method. The aim of the study was to assess the tissue microcirculation parameter changes in people performing yoga breathing exercises. Materials and methods. 25 volunteers performed yoga breathing exercises at a frequency of 3 times per minute, 2 times per minute, 1.5 times per minute, 1 time per minute for 5 minutes, and free breathing for 6 minutes before and after breathing exercises. Parameters aimed to defin the reaction of skin microcirculation in different body areas were simultaneously recorded in six sites by laser Doppler flowmetry using a distributed system of wearable analyzers. The parameters of tissue microcirculation recorded by the method of laser Doppler flowmetry were: the index of microcirculation (Im), nutritive blood flow (Imn), the amplitude of myogenic (Am), neurogenic (An), endothelial (Ae), respiratory (Ar) and cardiac (Ac) regulation circuits. Results. Yoga breathing exercises led to increase of microcirculation index at all breathing frequencies. Breathing at a frequency of 1.5 and 1/minute leads to a significant increase in nutritional blood flow. Low-frequency breathing exercises lead to an increase in blood pressure at the lowest breathing rates – 1.5/minute and 1/minute. The most significant changes were achieved at the lowest respiration rates (1 and 1.5/minute), that could be associated with hypoxic-hypercapnic mechanisms. Conclusion. The absence of significant changes in microcirculation parameters after low-frequency respiration during measurements in the supraorbital arteries in both groups characterizes the work of homeostatic mechanisms for maintaining brain perfusion in stressful situations for the body (low-frequency types of respiration, hypercapnia and hypoxia). When measured in the extremities, a change in the effect of the circulatory system regulatory mechanisms was observed; along with an increase in skin perfusion and the nutritional component, it can characterize the compensatory reaction of the microcirculation to respiration change.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>микроциркуляция</kwd><kwd>дыхание</kwd><kwd>йога</kwd><kwd>лазерная допплеровская флоуметрия</kwd><kwd>распределенная система носимых анализаторов</kwd></kwd-group><kwd-group xml:lang="en"><kwd>microcirculation</kwd><kwd>breathing</kwd><kwd>yoga</kwd><kwd>laser Doppler flowmetry</kwd><kwd>distributed system of wearable analyzers</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено при финансовой поддержке Российского фонда фундаментальных исследований в рамках гранта № 20-08-01153 А.</funding-statement><funding-statement xml:lang="en">The studies were funded by the Russian Foundation for Basic Research (the research project 20-08-01153).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">McKay JAA, McCulloch CL, Querido JS, Foster GE, Koehle MS, Sheel AW. The effect of consistent practice of yogic breathing exercises on the human cardiorespiratory system // Respiratory Physiology &amp; Neurobiology. 2016;(233):41–51. Doi: 10.1016/j.resp.2016.07.005.</mixed-citation><mixed-citation xml:lang="en">McKay JAA, McCulloch CL, Querido JS, Foster GE, Koehle MS, Sheel AW. The effect of consistent practice of yogic breathing exercises on the human cardiorespiratory system // Respiratory Physiology &amp; Neurobiology. 2016;(233):41–51. Doi: 10.1016/j.resp.2016.07.005.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Miyamura M, Nishimura K, Ishida K, Katayama K, Shimaoka M, Hiruta S. Is Man Able to Breathe Once a Minute for an Hour? The Effect of Yoga Respiration on Blood Gases // Japanese Journal of Physiology. 2002;(52):313–316. Doi: 10.2170/jjphysiol.52.313.</mixed-citation><mixed-citation xml:lang="en">Miyamura M, Nishimura K, Ishida K, Katayama K, Shimaoka M, Hiruta S. Is Man Able to Breathe Once a Minute for an Hour? The Effect of Yoga Respiration on Blood Gases // Japanese Journal of Physiology. 2002;(52):313–316. Doi: 10.2170/jjphysiol.52.313.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Tancredi FB, Hoge RD. Comparison of cerebral vascular reactivity measures obtained using breath-holding and CO2 inhalation // J Cereb Blood Flow Metab 2013;(33):1066–1074. Doi: 10.1038/jcbfm.2013.48.</mixed-citation><mixed-citation xml:lang="en">Tancredi FB, Hoge RD. Comparison of cerebral vascular reactivity measures obtained using breath-holding and CO2 inhalation // J Cereb Blood Flow Metab 2013;(33):1066–1074. Doi: 10.1038/jcbfm.2013.48.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Urback AL, MacIntosh BJ, Goldstein BI. Cerebrovascular reactivity measured by functional magnetic resonance imaging during breath-hold challenge: A systematic review // Neuroscience &amp; Biobehavioral Reviews. 2017;(79):27–47. Doi: 10.1016/j.neubiorev.2017.05.003.</mixed-citation><mixed-citation xml:lang="en">Urback AL, MacIntosh BJ, Goldstein BI. Cerebrovascular reactivity measured by functional magnetic resonance imaging during breath-hold challenge: A systematic review // Neuroscience &amp; Biobehavioral Reviews. 2017;(79):27–47. Doi: 10.1016/j.neubiorev.2017.05.003.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Corfield DR, Murphy K, Josephs O, Adams L, Turner R. Does hypercapnia-induced cerebral vasodilation modulate the hemodynamic response to neural activation? // Neuroimage. 2001;13(6):1207–1211. Doi: 10.1006/nimg.2001.0760.</mixed-citation><mixed-citation xml:lang="en">Corfield DR, Murphy K, Josephs O, Adams L, Turner R. Does hypercapnia-induced cerebral vasodilation modulate the hemodynamic response to neural activation? // Neuroimage. 2001;13(6):1207–1211. Doi: 10.1006/nimg.2001.0760.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Liu P, De Vis JB, Lu H. Cerebrovascular reactivity (CVR) MRI with CO2 challenge: A technical review // Neuroimage 2019;(187):104–115. Doi: 10.1016/j.neuroimage.2018.03.047.</mixed-citation><mixed-citation xml:lang="en">Liu P, De Vis JB, Lu H. Cerebrovascular reactivity (CVR) MRI with CO2 challenge: A technical review // Neuroimage 2019;(187):104–115. Doi: 10.1016/j.neuroimage.2018.03.047.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bright MG, Bulte DP, Jezzard P, Duyn JH. Characterization of regional heterogeneity in cerebrovascular reactivity dynamics using novel hypocapnia task and BOLD fMRI // Neuroimage. 2009;48(1):166–175. Doi: 10.1016/j.neuroimage.2009.05.026.</mixed-citation><mixed-citation xml:lang="en">Bright MG, Bulte DP, Jezzard P, Duyn JH. Characterization of regional heterogeneity in cerebrovascular reactivity dynamics using novel hypocapnia task and BOLD fMRI // Neuroimage. 2009;48(1):166–175. Doi: 10.1016/j.neuroimage.2009.05.026.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Chan ST, Evans KC, Song TY, Selb J, Kouwe A, Rosen BR, Zheng YP, Ahn A, Kwong KK. Cerebrovascular reactivity assessment with O2-CO2 exchange ratio under brief breath hold challenge // PLOS ONE. 2020;15(3):E0225915. Doi: 10.1371/journal.pone.0225915.</mixed-citation><mixed-citation xml:lang="en">Chan ST, Evans KC, Song TY, Selb J, Kouwe A, Rosen BR, Zheng YP, Ahn A, Kwong KK. Cerebrovascular reactivity assessment with O2-CO2 exchange ratio under brief breath hold challenge // PLOS ONE. 2020;15(3):E0225915. Doi: 10.1371/journal.pone.0225915.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Willie CK, Macleod DB, Shaw AD, Smith KJ, Tzeng YC, Eves ND, Ikeda K, Graham J, Lewis NC, Day TA, Ainslie PN. Regional brain blood flow in man during acute changes in arterial blood gases // J Physiol. 2012;590(14):3261–3275. Doi: 10.1113/jphysiol.2012.228551.</mixed-citation><mixed-citation xml:lang="en">Willie CK, Macleod DB, Shaw AD, Smith KJ, Tzeng YC, Eves ND, Ikeda K, Graham J, Lewis NC, Day TA, Ainslie PN. Regional brain blood flow in man during acute changes in arterial blood gases // J Physiol. 2012;590(14):3261–3275. Doi: 10.1113/jphysiol.2012.228551.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Bor-Seng-Shu E, Kita WS, Figueiredo EG, Paiva WS, Fonoff ET, Teixeira MJ, Panerai RB. Cerebral hemodynamics: concepts of clinical importance // Arq Neuropsiquiatr. 2012;70(5):352–356. Doi: 10.1590/s0004-282x2012000500010.</mixed-citation><mixed-citation xml:lang="en">Bor-Seng-Shu E, Kita WS, Figueiredo EG, Paiva WS, Fonoff ET, Teixeira MJ, Panerai RB. Cerebral hemodynamics: concepts of clinical importance // Arq Neuropsiquiatr. 2012;70(5):352–356. Doi: 10.1590/s0004-282x2012000500010.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Fierstra J, van Niftrik C, Warnock G, Wegener S, Piccirelli M, Pangalu A, Esposito G, Valavanis A, Buck A, Luft A, Bozinov O, Regli L. Staging Hemodynamic Failure With Blood Oxygen-Level-Dependent Functional Magnetic Resonance Imaging Cerebrovascular Reactivity: A Comparison Versus Gold Standard (15O-)H2O-Positron Emission Tomography // Stroke. 2018;49(3):621–629. Doi: 10.1161/STROKEAHA.117.020010.</mixed-citation><mixed-citation xml:lang="en">Fierstra J, van Niftrik C, Warnock G, Wegener S, Piccirelli M, Pangalu A, Esposito G, Valavanis A, Buck A, Luft A, Bozinov O, Regli L. Staging Hemodynamic Failure With Blood Oxygen-Level-Dependent Functional Magnetic Resonance Imaging Cerebrovascular Reactivity: A Comparison Versus Gold Standard (15O-)H2O-Positron Emission Tomography // Stroke. 2018;49(3):621–629. Doi: 10.1161/STROKEAHA.117.020010.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Tønnesen J, Pryds A, Larsen E, Paulson O, Hauerberg J, Knudsen G. Laser Doppler flowmetry is valid for measurement of cerebral blood flow autoregulation lower limit in rats // Experimental physiology. 2005;(90):349–355. Doi: 10.1113/expphysiol.2004.029512.</mixed-citation><mixed-citation xml:lang="en">Tønnesen J, Pryds A, Larsen E, Paulson O, Hauerberg J, Knudsen G. Laser Doppler flowmetry is valid for measurement of cerebral blood flow autoregulation lower limit in rats // Experimental physiology. 2005;(90):349–355. Doi: 10.1113/expphysiol.2004.029512.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Тюрина М. Й., Красников Г. В., Танканаг А. В. и др. Формирование респираторнозависимых колебаний скорости кровотока в микроциркуляторном русле кожи человека в условиях контролируемого дыхания // Регионарное кровообращение и микроциркуляция. – 2011. – Т. 10, № 3. – С. 31–37.</mixed-citation><mixed-citation xml:lang="en">Tyurina MY, Krasnikov GV, Tankanag AV, Piskunova GM, Chemeris NK. Formation of respiratory-dependent fluctuations in the blood flow velocity in the microcirculatory bed of the human skin under controlled breathing conditions // Regional blood circulation and microcirculation. 2011;10(3):31–37. (In Russ.). Doi: 10.24884/1682-6655-2011-10-3-31-37.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Анисимова А. В., Крупаткин А. И., Сидоров В. В. и др. Лазерная допплеровская флоуметрия в оценке состояния микроциркуляции у пациентов с острой и хронической цереброваскулярной недостаточностью // Регионарное кровообращение и микроциркуляция. – 2014. – Т. 13, № 3. – С. 31–37</mixed-citation><mixed-citation xml:lang="en">Anisimova AV, Krupatkin AI, Sidorov VV, Zacharkina MV, Yutskova EV, Galkin SS. Laser Doppler flowmetry in the assessment of the microcirculation in patients with acute and chronic cerebrovascular insufficiency // Regional blood circulation and microcirculation. 2014;13(3):31–37. (In Russ.). Doi: 10.24884/1682-6655-2014-13-3-31-37.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Goltsov A, Anisimova AV, Zakharkina M, Krupatkin AI, Sidorov VV, Sokolovski SG, Rafailov E. Bifurcation in Blood Oscillatory Rhythms for Patients with Ischemic Stroke: A Small Scale Clinical Trial using Laser Doppler Flowmetry and Computational Modeling of Vasomotion // Front Physiol. 2017;(8):160. Doi: 10.3389/fphys.2017.00160.</mixed-citation><mixed-citation xml:lang="en">Goltsov A, Anisimova AV, Zakharkina M, Krupatkin AI, Sidorov VV, Sokolovski SG, Rafailov E. Bifurcation in Blood Oscillatory Rhythms for Patients with Ischemic Stroke: A Small Scale Clinical Trial using Laser Doppler Flowmetry and Computational Modeling of Vasomotion // Front Physiol. 2017;(8):160. Doi: 10.3389/fphys.2017.00160.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Fedorovich AA, Loktionova YI, Zharkikh EV, Mikhailova MA, Popova JA, Suvorov AV, Zherebtsov EA. Body Position Affects Capillary Blood Flow Regulation Measured with Wearable Blood Flow Sensors // Diagnostics. 2021;11(3):436. Doi: 10.3390/diagnostics11030436.</mixed-citation><mixed-citation xml:lang="en">Fedorovich AA, Loktionova YI, Zharkikh EV, Mikhailova MA, Popova JA, Suvorov AV, Zherebtsov EA. Body Position Affects Capillary Blood Flow Regulation Measured with Wearable Blood Flow Sensors // Diagnostics. 2021;11(3):436. Doi: 10.3390/diagnostics11030436.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Жарких Е. В., Маковик И. Н., Потапова Е. В. Оптическая неинвазивная диагностика функционального состояния микроциркуляторного русла пациентов с нарушением периферической микрогемодинамики // Регионарное кровообращение и микроциркуляция. – 2018. – Т. 17, № 3. – С. 23–32.</mixed-citation><mixed-citation xml:lang="en">Zharkikh EV, Makovik IN, Potapova EV, Dremin VV, Zherebtsov EA, Zherebtsova AI, Dunaev AV, Sidorov VV, Krupatkin AI. Optical noninvasive diagnostics of the functional state of microcirculatory bed in patients with disorders of peripheral haemodynamics // Regional blood circulation and microcirculation. 2018;17(3):23–32. (In Russ.). Doi: 10.24884/1682-6655-2018-17-3-23-32.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Дремин В. В., Козлов И. О., Жеребцов Е. А. и др. Возможности лазерной допплеровской флоуметрии в оценке состояния микрогемолимфоциркуляции // Регионарное кровообращение и микроциркуляция. – 2017. – T. 16. – № 4. – C. 42–49.</mixed-citation><mixed-citation xml:lang="en">Dremin VV, Kozlov IO, Zherebtsov EA, Makovik IN, Dunaev AV, Sidorov VV, Krupatkin AI. The capabilities of laser Doppler flowmetry in assessment of lymph and blood microcirculation // Regional blood circulation and microcirculation. 2017;16(4):42–49. (In Russ.). Doi: 10.24884/1682-6655-2017-16-4-42-49.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Zharkikh EV, Loktionova YI, Masalygina GI, Krupatkin AI, Sidorov VV, Dunaev AV. Optical noninvasive diagnostics of dynamic changes in the level of blood microcirculation and oxidative metabolism using temperature tests // Proc. SPIE 11363. Tissue Optics and Photonics. 2020;1136321. Doi: 10.1117/12.2555870.</mixed-citation><mixed-citation xml:lang="en">Zharkikh EV, Loktionova YI, Masalygina GI, Krupatkin AI, Sidorov VV, Dunaev AV. Optical noninvasive diagnostics of dynamic changes in the level of blood microcirculation and oxidative metabolism using temperature tests // Proc. SPIE 11363. Tissue Optics and Photonics. 2020;1136321. Doi: 10.1117/12.2555870.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Makovik IN, Dunaev AV, Dremin VV, Krupatkin AI, Sidorov VV, Khakhicheva LS, Muradyan VF, Pilipenko OV, Rafailov IE, Litvinova KS. Detection of angiospastic disorders in the microcirculatory bed using laser diagnostics technologies // Journal of Innovative Optical Health Sciences. 2017; 11(1):750016. Doi: 10.1142/S179354581750016X.</mixed-citation><mixed-citation xml:lang="en">Makovik IN, Dunaev AV, Dremin VV, Krupatkin AI, Sidorov VV, Khakhicheva LS, Muradyan VF, Pilipenko OV, Rafailov IE, Litvinova KS. Detection of angiospastic disorders in the microcirculatory bed using laser diagnostics technologies // Journal of Innovative Optical Health Sciences. 2017; 11(1):750016. Doi: 10.1142/S179354581750016X.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
