microcirculationРегионарное кровообращение и микроциркуляцияRegional blood circulation and microcirculation1682-66552712-9756Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1682-6655-2022-21-1-87-94microcirculation-1045Research ArticleЛЕКЦИИLECTURESТрансплантация и реконструкция трахеи: состояние проблемыTracheal transplantation and reconstruction: state of the problemhttps://orcid.org/0000-0001-8698-7018АкоповА. Л.AkopovA. L.

Акопов Андрей Леонидович – д-р мед. наук, профессор,руководитель отдела торакальной хирургии инеотложной медицины, зав. кафедрой клинической анатомиии оперативной хирургии 

197022, Россия, Санкт-Петербург, ул. Льва Толстого, д. 6-8

Akopov Andrey L. – doctor of medical sciences, professor, Head of the department of thoracic surgery of institute ofsurgery and emergency medicine, Head of the department ofclinical anatomy and operative Surgery named after professor 

6-8, L’va Tolstogo str., Saint Petersburg, Russia, 197022

akopovand@mail.ruИльинА. А.IlinA. A.

Ильин Андрей Андреевич – канд. мед. наук, врач – торакальный хирург Нии хирургии и неотложной медицины, ассистент кафедры клинической анатомии и оперативнойхирурги

197022, Россия, Санкт-Петербург, ул. Льва Толстого, д. 6-8

Ilin Andrey A. – candidate of medical sciences, Thoracicsurgeon of the department of thoracic surgery of institute of surgery and emergency medicine, Assistant of the department ofclinical anatomy and operative Surgery named after professorM. G. Privesa

6-8, L’va Tolstogo str., Saint Petersburg, Russia, 197022

https://orcid.org/0000-0002-1250-8763СидельниковаЭ. В.SidelnikovaE. V.

Сидельникова Эллина Валерьевна – студентка

197022, Россия, Санкт-Петербург, ул. Льва Толстого, д. 6-8

Sidelnikova Ellina V. – Student

6-8, L’va Tolstogo str., Saint Petersburg, Russia, 197022

Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияPavlov UniversityRussian Federation2022110420222118794Copyright © Акопов А.Л., Ильин А.А., Сидельникова Э.В., 20222022Акопов А.Л., Ильин А.А., Сидельникова Э.В.Akopov A.L., Ilin A.A., Sidelnikova E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.microcirc.ru/jour/article/view/1045

Трахея является одним из самых сложных органов для трансплантации, поскольку ее сегментарное кровоснабжение обеспечивается сосудами, имеющими слишком малый диаметр для микрососудистого анастомоза. Именно сохранение адекватного кровоснабжения и, соответственно, микроциркуляции является ключевым моментом успеха трансплантации этого органа. Возможность использования биопротезов для замены трахеи находится в стадии исследований. Всего несколько групп исследователей в мире разрабатывали собственные варианты техники трансплантации трахеи, однако говорить о решении проблемы в настоящее время не приходится. В статье описаны предпринятые и текущие направления исследований в области трансплантации и реконструкции трахеи.

Trachea is one of the most difficult organs for transplantation because of its segmental blood supply is provided by vessels which are too small for microvascular anastomosis. An effective vascular supply and, respectively, microcirculation is fundamental for successful transplantation of this organ. The possibility of using bioprosthesis for tracheal replacement is under investigation. Only few groups of researchers over the world have developed their own techniques of tracheal transplantation, but at present time the problem is not resolved. This review describes past and current researches in the field of tracheal transplantation and reconstruction. 

трахеятрансплантацияваскуляризациямикроциркуляциятканевая инженерияtracheatransplantationvascularizationmicrocirculationtissue engineeringReferencesMathisen DJ. Tracheal Resection and Reconstruction: How I Teach It // Ann. Thorac. Surg. 2017;(103):1043–1048. Doi: 10.1016/j.athoracsur.2016.12.057.Mathisen DJ. Tracheal Resection and Reconstruction: How I Teach It // Ann. Thorac. Surg. 2017;(103):1043–1048. Doi: 10.1016/j.athoracsur.2016.12.057.Паршин В. Д., Порханов В. А. Хирургия трахеи с атласом оперативной хирургии: монография. – М.: АльдиПринт, 2010. – 480 с.Parshin VD, Porkhanov VA. Surgery of trachea with atlas of operative surgery: The monography. Moscow, 2010:480. (In Russ.).Toomes H, Mickisch G, Vogt-Moykopf I. Experiences with prosthetic reconstruction of the trachea and bifurcation // Thorax. 1985;(40):32–37. Doi: 10.1136/thx.40.1.32Toomes H, Mickisch G, Vogt-Moykopf I. Experiences with prosthetic reconstruction of the trachea and bifurcation // Thorax. 1985;(40):32–37. Doi: 10.1136/thx.40.1.32Delaere P, Vranckx J, Meulemans J et. al. Learning curve in tracheal allotransplantation // Am J Transpl. 2012;(12):2538– 2545. Doi: 10.1111/j.1600-6143.2012.04125.x.Delaere P, Vranckx J, Meulemans J et. al. Learning curve in tracheal allotransplantation // Am J Transpl. 2012;(12):2538– 2545. Doi: 10.1111/j.1600-6143.2012.04125.x.Abruzzo A, Fiorica C, Palumbo VD, Altomare R, Damiano G, Gioviale MC, Tomasello G, Licciardi M, Palumbo F.S, Giammona G et al. Using polymeric scaffolds for vascular tissue engineering // Int. J. Polym. Sci. 2014;(2014). Doi: 10.1155/2014/689390.Abruzzo A, Fiorica C, Palumbo VD, Altomare R, Damiano G, Gioviale MC, Tomasello G, Licciardi M, Palumbo F.S, Giammona G et al. Using polymeric scaffolds for vascular tissue engineering // Int. J. Polym. Sci. 2014;(2014). Doi: 10.1155/2014/689390.Паршин В. Д., Тарабрин Е. А., Русаков М. А. и др. Клинико-экспериментальные исследования в трансплантации реваскуляризированной трахеи // Анналы пласт., реконструктив. и эстет. хир. – 2016. – № 1. – С. 99–100.Parshin VD, Tarabrin EA, Rusakov MA i dr. Kliniko-jeksperimental’nye issledovanija v transplantacii revaskuljarizirovannoj trahei // Plastic Surgery and Aesthetic Medicine. 2016;(1):99–100. (In Russ.).Акопов А. Л., Папаян Г. В., Ефимов А. Н. и др. Инфракрасная флюоресцентная ангиография при трансплантации трахеи в эксперименте // Бюлл. эксперимент. биологии и мед. – 2017. – Т. 164, № 10. – С. 525–528.Akopov AL, Papayan GV, Yefimov AN, Nikityuk DB, Yaprintsev VO, Magruk MA. Infrakrasnaya fluorestsentnaya angiografiya pri transplantatsii trakhei v eksperimente // Bulletin of Experimental Biology and Medicine. 2017;164(10):525–528. (In Russ.).Delaere P, Lerut T, van Raemdonck D. Tracheal Transplantation: State of the Art and Key Role of Blood Supply in Its Success // Thorac Surg Clin. 2018;28(3):337–345. Doi: 10.1016/j.thorsurg.2018.05.002.Delaere P, Lerut T, van Raemdonck D. Tracheal Transplantation: State of the Art and Key Role of Blood Supply in Its Success // Thorac Surg Clin. 2018;28(3):337–345. Doi: 10.1016/j.thorsurg.2018.05.002.Ferguson DJ, Wild JJ, Wangensteen OH. Experimental resection of the trachea // Surgery. 1950;28(3):597–619.Ferguson DJ, Wild JJ, Wangensteen OH. Experimental resection of the trachea // Surgery. 1950;28(3):597–619.Pacheco CR, Rivero O, Porter JK. Experimental reconstructive surgery of the trachea // J Thorac Surg. 1954; 27(6):554–564.Pacheco CR, Rivero O, Porter JK. Experimental reconstructive surgery of the trachea // J Thorac Surg. 1954; 27(6):554–564.Grillo HC. Tracheal replacement: a critical review // Ann Thorac Surg. 2002;73(6):1995–2004. Doi:10.1016/ s0003-4975(02)03564-6Grillo HC. Tracheal replacement: a critical review // Ann Thorac Surg. 2002;73(6):1995–2004. Doi:10.1016/ s0003-4975(02)03564-6Yokomise H, Inui K, Wada H, Ueda M, Hitomi S. Longterm cryopreservation can prevent rejection of canine tracheal allografts with preservation of graft viability // J Thorac Cardiovasc Surg. 1996;111(5):930–934. Doi:10.1016/s0022- 5223(96)70366-5.Yokomise H, Inui K, Wada H, Ueda M, Hitomi S. Longterm cryopreservation can prevent rejection of canine tracheal allografts with preservation of graft viability // J Thorac Cardiovasc Surg. 1996;111(5):930–934. Doi:10.1016/s0022- 5223(96)70366-5.Jacobs JP, Quintessenza JA, Andrews T et al. Tracheal allograft reconstruction: the total North American and worldwide pediatric experiences // Ann Thorac Surg. 1999; 68(3):1043–1052. Doi:10.1016/s0003-4975(99)00878-4Jacobs JP, Quintessenza JA, Andrews T et al. Tracheal allograft reconstruction: the total North American and worldwide pediatric experiences // Ann Thorac Surg. 1999; 68(3):1043–1052. Doi:10.1016/s0003-4975(99)00878-4Niwaya K, Sakaguchi H, Kawachi K, Kitamura S. Effect of warm ischemia and cryopreservation on cell viability of human allograft valves // Ann Thorac Surg. 1995;60 (2 Suppl):S114–S117. Doi: 10.1016/0003-4975(95)00204-xNiwaya K, Sakaguchi H, Kawachi K, Kitamura S. Effect of warm ischemia and cryopreservation on cell viability of human allograft valves // Ann Thorac Surg. 1995;60 (2 Suppl):S114–S117. Doi: 10.1016/0003-4975(95)00204-xRose KG, Sesterhenn K, Wustrow F. Tracheal allotransplantation in man // Lancet. 197924;1(8113):433. Doi: 10. 1016/s0140-6736(79)90902-4.Rose KG, Sesterhenn K, Wustrow F. Tracheal allotransplantation in man // Lancet. 197924;1(8113):433. Doi: 10. 1016/s0140-6736(79)90902-4.Levashov YuN, Yablonsky PK, Cherny SM, Orlov SV, Shafirovsky BB, Kuznetzov IM. One-stage allotransplantation of thoracic segment of the trachea in a patient with idiopathic fibrosing mediastinitis and marked tracheal stenosis // Eur J Cardiothorac Surg. 1993;7(7):383–386. Doi: 10.1016/1010- 7940(93)90071-i.Levashov YuN, Yablonsky PK, Cherny SM, Orlov SV, Shafirovsky BB, Kuznetzov IM. One-stage allotransplantation of thoracic segment of the trachea in a patient with idiopathic fibrosing mediastinitis and marked tracheal stenosis // Eur J Cardiothorac Surg. 1993;7(7):383–386. Doi: 10.1016/1010- 7940(93)90071-i.Паршин В. Д., Люндуп А. В., Тарабрин Е. А. и др. Отдаленный результат трансплантации трахеи: успех и нерешенные проблемы // Хирургия: Журнал им. Н. И. Пирогова. – 2018. – № 11. – С. 11–19.Parshin VD, Lyundup AV, Tarabrin EA, Parshin VV. Long-term oucomes of tracheal transplantation: success and unsolved problems. //Pirogov. Russian Journal of Surgery. 2018; (11):11–19 (In Russ.). Doi: 10.17116/hirurgia201811111.Jacobs JP, Elliott MJ, Haw MP, Bailey CM, Herberhold C. Pediatric tracheal homograft reconstruction: a novel approach to complex tracheal stenoses in children // J Thorac Cardiovasc Surg. 1996;112(6):1549–1558. Doi: 10.1016/ S0022-5223(96)70014-4.Jacobs JP, Elliott MJ, Haw MP, Bailey CM, Herberhold C. Pediatric tracheal homograft reconstruction: a novel approach to complex tracheal stenoses in children // J Thorac Cardiovasc Surg. 1996;112(6):1549–1558. Doi: 10.1016/ S0022-5223(96)70014-4.Delaere P, Vranckx J, Verleden G, De Leyn P, van Raemdonck D. Leuven Tracheal Transplant Group. Tracheal allotransplantation after withdrawal of immunosuppressive therapy // N Engl J Med. 2010;362(2):138–145. Doi: 10.1056/ NEJMoa0810653.Delaere P, Vranckx J, Verleden G, De Leyn P, van Raemdonck D. Leuven Tracheal Transplant Group. Tracheal allotransplantation after withdrawal of immunosuppressive therapy // N Engl J Med. 2010;362(2):138–145. Doi: 10.1056/ NEJMoa0810653.Genden EM, Miles BA, Harkin TJ, DeMaria S, Kaufman AJ, Mayland E, Kaul VF, Florman SS Single-stage long-segment tracheal transplantation // Am J Transplant. 2021;21(10):3421–3427. Doi: 10.1111/ajt.16752.Genden EM, Miles BA, Harkin TJ, DeMaria S, Kaufman AJ, Mayland E, Kaul VF, Florman SS Single-stage long-segment tracheal transplantation // Am J Transplant. 2021;21(10):3421–3427. Doi: 10.1111/ajt.16752.Martinod E, Seguin A, Radu DM, Boddaert G, Chouahnia K, Fialaire-Legendre A, Dutau H, Vénissac N, Marquette CH, Baillard C, Valeyre D, Carpentier A; French Group for Airway Transplantation (FREGAT). Airway transplantation: a challenge for regenerative medicine // Eur J Med Res. 2013;18(1):25. Doi: 10.1186/2047-783X-18-25.Martinod E, Seguin A, Radu DM, Boddaert G, Chouahnia K, Fialaire-Legendre A, Dutau H, Vénissac N, Marquette CH, Baillard C, Valeyre D, Carpentier A; French Group for Airway Transplantation (FREGAT). Airway transplantation: a challenge for regenerative medicine // Eur J Med Res. 2013;18(1):25. Doi: 10.1186/2047-783X-18-25.Wurtz A, Porte H, Conti M, Desbordes J, Copin MC, Azorin J, Martinod E, Marquette CH. Tracheal replacement with aortic allografts // N Engl J Med. 2006;355(18):1938– 1940. Doi: 10.1056/NEJMc066336Wurtz A, Porte H, Conti M, Desbordes J, Copin MC, Azorin J, Martinod E, Marquette CH. Tracheal replacement with aortic allografts // N Engl J Med. 2006;355(18):1938– 1940. Doi: 10.1056/NEJMc066336Wurtz A, Porte H, Conti M, Dusson C, Desbordes J, Copin MC, Marquette CH. Surgical technique and results of tracheal and carinal replacement with aortic allografts for salivary gland-type carcinoma // J Thorac Cardiovasc Surg. 2010;140(2):387-393.e2. Doi: 10.1016/j.jtcvs.2010.01.043.Wurtz A, Porte H, Conti M, Dusson C, Desbordes J, Copin MC, Marquette CH. Surgical technique and results of tracheal and carinal replacement with aortic allografts for salivary gland-type carcinoma // J Thorac Cardiovasc Surg. 2010;140(2):387-393.e2. Doi: 10.1016/j.jtcvs.2010.01.043.Mercier O, Kolb F, Dartevelle PG. Autologous Tracheal Replacement: Surgical Technique and Outcomes // Thorac Surg Clin. 2018;28(3):347–355. Doi: 10.1016/j.thorsurg.2018.05.007Mercier O, Kolb F, Dartevelle PG. Autologous Tracheal Replacement: Surgical Technique and Outcomes // Thorac Surg Clin. 2018;28(3):347–355. Doi: 10.1016/j.thorsurg.2018.05.007Auchincloss HG, Wright CD. Complications after tracheal resection and reconstruction: prevention and treatment // J Thorac Dis. 2016;8(2):160–167. Doi: 10.3978/j.issn.2072- 1439.2016.01.86.Auchincloss HG, Wright CD. Complications after tracheal resection and reconstruction: prevention and treatment // J Thorac Dis. 2016;8(2):160–167. Doi: 10.3978/j.issn.2072- 1439.2016.01.86.Haseltine WA. Interview: commercial translation of cell-based therapies and regenerative medicine: learning by experience. Interview by Emily Culme-Seymour // Regen Med. 2011;6(4):431–435. Doi: 10.2217/rme.11.40.Haseltine WA. Interview: commercial translation of cell-based therapies and regenerative medicine: learning by experience. Interview by Emily Culme-Seymour // Regen Med. 2011;6(4):431–435. Doi: 10.2217/rme.11.40.Dhasmana A, Singh A, Rawal S. Biomedical grafts for tracheal tissue repairing and regeneration «Tracheal tissue engineering: an overview» // J Tissue Eng Regen Med. 2020; 14(5):653–672. Doi: 10.1002/term.3019Dhasmana A, Singh A, Rawal S. Biomedical grafts for tracheal tissue repairing and regeneration «Tracheal tissue engineering: an overview» // J Tissue Eng Regen Med. 2020; 14(5):653–672. Doi: 10.1002/term.3019Damiano G, Palumbo VD, Fazzotta S, Curione F, Lo Monte G, Brucato VMB, Lo Monte AI. Current Strategies for Tracheal Replacement: A Review // Life (Basel). 2021; 11(7):618. Doi: 10.3390/life11070618.Damiano G, Palumbo VD, Fazzotta S, Curione F, Lo Monte G, Brucato VMB, Lo Monte AI. Current Strategies for Tracheal Replacement: A Review // Life (Basel). 2021; 11(7):618. Doi: 10.3390/life11070618.Palumbo VD, Bruno A, Tomasello G, Damiano G, Lo Monte AI. Bioengineered vascular scaffolds: the state of the art // Int J Artif Organs. 2014;37(7):503–512. Doi: 10.5301/ ijao.5000343. Epub 2014 Jul 4Palumbo VD, Bruno A, Tomasello G, Damiano G, Lo Monte AI. Bioengineered vascular scaffolds: the state of the art // Int J Artif Organs. 2014;37(7):503–512. Doi: 10.5301/ ijao.5000343. Epub 2014 Jul 4Macchiarini P, Jungebluth P, Go T, Asnaghi MA, Rees LE, Cogan TA, Dodson A, Martorell J, Bellini S, Parnigotto PP, Dickinson SC, Hollander AP, Mantero S, Conconi MT, Birchall MA. Clinical transplantation of a tissue-engineered airway // Lancet. 2008;372(9655):2023–2030. Doi: 10.1016/ S0140-6736(08)61598-6Macchiarini P, Jungebluth P, Go T, Asnaghi MA, Rees LE, Cogan TA, Dodson A, Martorell J, Bellini S, Parnigotto PP, Dickinson SC, Hollander AP, Mantero S, Conconi MT, Birchall MA. Clinical transplantation of a tissue-engineered airway // Lancet. 2008;372(9655):2023–2030. Doi: 10.1016/ S0140-6736(08)61598-6Chiang T, Pepper V, Best C, Onwuka E, Breuer CK. Clinical Translation of Tissue Engineered Trachea Grafts // Ann Otol Rhinol Laryngol. 2016;125(11):873–885. Doi: 10. 1177/0003489416656646.Chiang T, Pepper V, Best C, Onwuka E, Breuer CK. Clinical Translation of Tissue Engineered Trachea Grafts // Ann Otol Rhinol Laryngol. 2016;125(11):873–885. Doi: 10. 1177/0003489416656646.Gonfiotti A, Jaus MO, Barale D, Baiguera S, Comin C, Lavorini F, Fontana G, Sibila O, Rombolà G, Jungebluth P, Macchiarini P. The first tissue-engineered airway transplantation: 5-year follow-up results // Lancet. 2014;383(9913):238– 244. Doi: 10.1016/S0140-6736(13)62033-4Gonfiotti A, Jaus MO, Barale D, Baiguera S, Comin C, Lavorini F, Fontana G, Sibila O, Rombolà G, Jungebluth P, Macchiarini P. The first tissue-engineered airway transplantation: 5-year follow-up results // Lancet. 2014;383(9913):238– 244. Doi: 10.1016/S0140-6736(13)62033-4Elliott MJ, De Coppi P, Speggiorin S, Roebuck D, Butler CR, Samuel E, Crowley C, McLaren C, Fierens A, Vondrys D, Cochrane L, Jephson C, Janes S, Beaumont NJ, Cogan T, Bader A, Seifalian AM, Hsuan JJ, Lowdell MW, Birchall MA. Stemcell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study // Lancet. 2012;380(9846):994–1000. Doi: 10.1016/S0140-6736(12)60737-5.Elliott MJ, De Coppi P, Speggiorin S, Roebuck D, Butler CR, Samuel E, Crowley C, McLaren C, Fierens A, Vondrys D, Cochrane L, Jephson C, Janes S, Beaumont NJ, Cogan T, Bader A, Seifalian AM, Hsuan JJ, Lowdell MW, Birchall MA. Stemcell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study // Lancet. 2012;380(9846):994–1000. Doi: 10.1016/S0140-6736(12)60737-5.Hamilton NJ, Kanani M, Roebuck DJ, Hewitt RJ, Cetto R, Culme-Seymour EJ, Toll E, Bates AJ, Comerford AP, McLaren CA, Butler CR, Crowley C, McIntyre D, Sebire NJ, Janes SM, O’Callaghan C, Mason C, De Coppi P, Lowdell MW, Elliott MJ, Birchall MA. Tissue-Engineered Tracheal Replacement in a Child: A 4-Year Follow-Up Study // Am J Transplant. 2015;15(10):2750–2757. Doi: 10.1111/ajt.13318Hamilton NJ, Kanani M, Roebuck DJ, Hewitt RJ, Cetto R, Culme-Seymour EJ, Toll E, Bates AJ, Comerford AP, McLaren CA, Butler CR, Crowley C, McIntyre D, Sebire NJ, Janes SM, O’Callaghan C, Mason C, De Coppi P, Lowdell MW, Elliott MJ, Birchall MA. Tissue-Engineered Tracheal Replacement in a Child: A 4-Year Follow-Up Study // Am J Transplant. 2015;15(10):2750–2757. Doi: 10.1111/ajt.13318Jungebluth P, Alici E, Baiguera S, Blomberg P, Bozóky B, Crowley C, Einarsson O, Gudbjartsson T, Le Guyader S, Henriksson G, Hermanson O, Juto JE, Leidner B, Lilja T, Liska J, Luedde T, Lundin V, Moll G, Roderburg C, Strömblad S, Sutlu T, Watz E, Seifalian A, Macchiarini P. Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study // Lancet. 2011;378(9808):1997–2004. Doi: 10.1016/S0140-6736(11)61715-7.Jungebluth P, Alici E, Baiguera S, Blomberg P, Bozóky B, Crowley C, Einarsson O, Gudbjartsson T, Le Guyader S, Henriksson G, Hermanson O, Juto JE, Leidner B, Lilja T, Liska J, Luedde T, Lundin V, Moll G, Roderburg C, Strömblad S, Sutlu T, Watz E, Seifalian A, Macchiarini P. Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study // Lancet. 2011;378(9808):1997–2004. Doi: 10.1016/S0140-6736(11)61715-7.Claesson-Welsh L, Hansson GK; Royal Swedish Academy of Sciences. Tracheobronchial transplantation: The Royal Swedish Academy of Sciences’ concerns // Lancet. 2016; 387(10022):942. Doi: 10.1016/S0140-6736(16)00520-1Claesson-Welsh L, Hansson GK; Royal Swedish Academy of Sciences. Tracheobronchial transplantation: The Royal Swedish Academy of Sciences’ concerns // Lancet. 2016; 387(10022):942. Doi: 10.1016/S0140-6736(16)00520-1Teixeira da Silva JA. Ethical perspectives and ramifications of the Paolo Macchiarini case // Indian J Med Ethics. 2017;2(4):270–275. Doi: 10.20529/IJME.2017.048.Teixeira da Silva JA. Ethical perspectives and ramifications of the Paolo Macchiarini case // Indian J Med Ethics. 2017;2(4):270–275. Doi: 10.20529/IJME.2017.048.Lo Monte AI, Licciardi M, Bellavia M, Damiano G, Palumbo VD, Palumbo FS, Abruzzo A, Fiorica C, Pitarresi G, Cacciabaudo F et al Biocompatibility and biodegradability of electrospun PHEA-PLA scaffolds: Our preliminary experience in a murine animal model // Dig. J. Nanomat. Biostruct. 2012;(7):841–851.Lo Monte AI, Licciardi M, Bellavia M, Damiano G, Palumbo VD, Palumbo FS, Abruzzo A, Fiorica C, Pitarresi G, Cacciabaudo F et al Biocompatibility and biodegradability of electrospun PHEA-PLA scaffolds: Our preliminary experience in a murine animal model // Dig. J. Nanomat. Biostruct. 2012;(7):841–851.Александров В. Н., Калюжная-Земляная Л. И., Фирсанов Д. В. и др. Трансплантация тканеинженерной трахеи как альтернативы аллогенной трахеи / // Вестн. хир. им. И. И. Грекова. 2017;176(4):110–114.Aleksandrov VN, Kalyuzhnaya LI, Firsanov DV, Kriventsov AV, Kondratenko AA, Figurkina MAб Transplantation of tissue-engineering trachea as alternative to allogenic trachea. Grekov’s Bulletin of Surgery. 2017;176(4):110–114. (In Russ.).Sun F, Pan S, Shi HC, Zhang FB, Zhang WD, Ye G, Liu XC, Zhang SQ, Zhong CH, Yuan XL Structural integrity, immunogenicity and biomechanical evaluation of rabbit decellularized tracheal matrix // J. Biomed. Mater. Res. Part A. 2015;(103):1509–1519.Sun F, Pan S, Shi HC, Zhang FB, Zhang WD, Ye G, Liu XC, Zhang SQ, Zhong CH, Yuan XL Structural integrity, immunogenicity and biomechanical evaluation of rabbit decellularized tracheal matrix // J. Biomed. Mater. Res. Part A. 2015;(103):1509–1519.Batioglu-Karaaltin A, Karaaltin MV, Ovali E, Yigit O, Kongur M, Inan O, Bozkurt E, Cansiz H. In vivo tissue-engineered allogenic trachea transplantation in rabbits: a preliminary report // Stem Cell Rev Rep. 2015;11(2):347–356. Вoi: 10.1007/s12015-014-9570-8Batioglu-Karaaltin A, Karaaltin MV, Ovali E, Yigit O, Kongur M, Inan O, Bozkurt E, Cansiz H. In vivo tissue-engineered allogenic trachea transplantation in rabbits: a preliminary report // Stem Cell Rev Rep. 2015;11(2):347–356. Вoi: 10.1007/s12015-014-9570-8Conconi MT, De Coppi P, Di Liddo R, Vigolo S, Zanon GF, Parnigotto PP, Nussdorfer GG. Tracheal matrices, obtained by a detergent-enzymatic method, support in vitro the adhesion of chondrocytes and tracheal epithelial cells // Transpl Int. 2005;18(6):727–734. Вoi: 10.1111/j.1432-2277.2005.00082.x.Conconi MT, De Coppi P, Di Liddo R, Vigolo S, Zanon GF, Parnigotto PP, Nussdorfer GG. Tracheal matrices, obtained by a detergent-enzymatic method, support in vitro the adhesion of chondrocytes and tracheal epithelial cells // Transpl Int. 2005;18(6):727–734. Вoi: 10.1111/j.1432-2277.2005.00082.x.Berg M, Ejnell H, Kovács A, Nayakawde N, Patil PB, Joshi M, Aziz L, Rådberg G, Hajizadeh S, Olausson M, Sumitran-Holgersson S. Replacement of a tracheal stenosis with a tissue-engineered human trachea using autologous stem cells: a case report // Tissue Eng Part A. 2014;20(1–2):389–397. Вoi: 10.1089/ten.TEA.2012.0514.Berg M, Ejnell H, Kovács A, Nayakawde N, Patil PB, Joshi M, Aziz L, Rådberg G, Hajizadeh S, Olausson M, Sumitran-Holgersson S. Replacement of a tracheal stenosis with a tissue-engineered human trachea using autologous stem cells: a case report // Tissue Eng Part A. 2014;20(1–2):389–397. Вoi: 10.1089/ten.TEA.2012.0514.Гилевич И. В., Сотниченко А. С., Карал-Оглы Д. Д. и др. Исследование биологической совместимости тканеинженерной конструкции трахеи в эксперименте in vivo на лабораторных приматах // Бюллетень эксперимент. биологии и мед. – 2017. – Т. 164, № 12. – С. 744– 748.Gilevich IV, Sotnichenko AS, Karal-Ogly DD et al. Issledovaniye biologicheskoy sovmestimosti tkaneinzhenernoy konstruktsii trakhei v eksperi_mente in vivo na laboratornykh primatakh // Byulleten Eksperimental’noy Biologii i Meditsiny. 2017; 164(12):744–748. (In Russ.).Акопов А. Л., Папаян Г. В., Горбунков С. Д. и др. Возможности флуоресцентной визуализации в оценке реваскуляризации гетеротопически трансплантированного сегмента трахеи приматов // Вестн. трансплантологии и искусственных органов. – 2020. – Т. 22, № 2. – С. 80– 85.Akopov AL, Papayan GV, Gorbunkov SD, Orlov SV, Karal-Ogly DD, Kaplanyan PA, Gubareva EA, Kuevda EV, Kuznetsova DM. Fluorescence imaging in evaluating the revascularization of heterotopically transplanted primate trachea segment // Russian Journal of Transplantology and Artificial Organs. 2020;22(2):80–85. (In Russ.). Doi 10. 15825/1995-1191-2020-2-80-85.Tan Q, Liu R, Chen X, Wu J, Pan Y, Lu S, Weder W, Luo Q. Clinic application of tissue engineered bronchus for lung cancer treatment // J Thorac Dis. 2017;9(1):22–29. Doi: 10.21037/jtd.2017.01.50Tan Q, Liu R, Chen X, Wu J, Pan Y, Lu S, Weder W, Luo Q. Clinic application of tissue engineered bronchus for lung cancer treatment // J Thorac Dis. 2017;9(1):22–29. Doi: 10.21037/jtd.2017.01.50Демидчик Е. Ю., Жарков В. В., Подгайский В. Н. и др. Трансплантация тканеинженерной трахеи (случай из практики) // Вопросы онкологии. – 2019. – Т. 65, № 2. – С. 283–286.Demidchik EJu, Zharkov VV, Podgajskij VN, Isajkina JaI, Lavrinovich KJu. Trachea transplantation (case report) // Problems in oncology. 2019;65(2):283–286. (In Russ.). Doi: 10.37469/0507-3758-2019-65-2-283-286.Park HS, Park HJ, Lee J, Kim P, Lee JS, Lee YJ, Seo YB, Kim DY, Ajiteru O, Lee OJ, Park CH. A 4-Axis Technique for Three-Dimensional Printing of an Artificial Trachea // Tissue Eng Regen Med. 2018;15(4):415–425. Doi: 10.1007/s13770- 018-0136-8.Park HS, Park HJ, Lee J, Kim P, Lee JS, Lee YJ, Seo YB, Kim DY, Ajiteru O, Lee OJ, Park CH. A 4-Axis Technique for Three-Dimensional Printing of an Artificial Trachea // Tissue Eng Regen Med. 2018;15(4):415–425. Doi: 10.1007/s13770- 018-0136-8.Cannella V, Piccione G, Altomare R, Marino A, Di Marco P, Russotto L, Di Bella S, Purpari G, Gucciardi F, Cassa ta G, Damiano G, Palumbo VD, Santoro A, Russo Lacerna C, Lo Monte AI, Guercio A. Differentiation and characterization of rat adipose tissue mesenchymal stem cells into endothelial-like cells // Anat Histol Embryol. 2018;47(1):11–20. Doi: 10.1111/ahe.12318.Cannella V, Piccione G, Altomare R, Marino A, Di Marco P, Russotto L, Di Bella S, Purpari G, Gucciardi F, Cassa ta G, Damiano G, Palumbo VD, Santoro A, Russo Lacerna C, Lo Monte AI, Guercio A. Differentiation and characterization of rat adipose tissue mesenchymal stem cells into endothelial-like cells // Anat Histol Embryol. 2018;47(1):11–20. Doi: 10.1111/ahe.12318.Gustafsson Y, Haag J, Jungebluth P, Lundin V, Lim ML, Baiguera S, Ajalloueian F, Del Gaudio C, Bianco A, Moll G, Sjöqvist S, Lemon G, Teixeira AI, Macchiarini P. Viability and proliferation of rat MSCs on adhesion protein-modified PET and PU scaffolds // Biomaterials. 2012;33(32):8094–8103. Doi: 10.1016/j.biomaterials.2012.07.060.Gustafsson Y, Haag J, Jungebluth P, Lundin V, Lim ML, Baiguera S, Ajalloueian F, Del Gaudio C, Bianco A, Moll G, Sjöqvist S, Lemon G, Teixeira AI, Macchiarini P. Viability and proliferation of rat MSCs on adhesion protein-modified PET and PU scaffolds // Biomaterials. 2012;33(32):8094–8103. Doi: 10.1016/j.biomaterials.2012.07.060.Shi H, Wang W, Lu D, Li H, Chen L, Lu Y, Zeng Y. Cellular biocompatibility and biomechanical properties of N-carboxyethylchitosan/nanohydroxyapatite composites for tissue-engineered trachea // Artif Cells Blood Substit Immobil Biotechnol. 2012;40(1–2):120–124. Doi: 10.3109/10731199.2011.597760.Shi H, Wang W, Lu D, Li H, Chen L, Lu Y, Zeng Y. Cellular biocompatibility and biomechanical properties of N-carboxyethylchitosan/nanohydroxyapatite composites for tissue-engineered trachea // Artif Cells Blood Substit Immobil Biotechnol. 2012;40(1–2):120–124. Doi: 10.3109/10731199.2011.597760.Huang L, Wang L, He J, Zhao J, Zhong D, Yang G, Guo T, Yan X, Zhang L, Li D, Cao T, Li X. Tracheal suspension by using 3-dimensional printed personalized scaffold in a patient with tracheomalacia // J Thorac Dis. 2016;8(11):3323– 3328. Doi: 10.21037/jtd.2016.10.53.Huang L, Wang L, He J, Zhao J, Zhong D, Yang G, Guo T, Yan X, Zhang L, Li D, Cao T, Li X. Tracheal suspension by using 3-dimensional printed personalized scaffold in a patient with tracheomalacia // J Thorac Dis. 2016;8(11):3323– 3328. Doi: 10.21037/jtd.2016.10.53.Huang L, Wang L, He J, Zhao J, Zhong D, Yang G, Guo T, Yan X, Zhang L, Li D, Cao T, Li X. Tracheal suspension by using 3-dimensional printed personalized scaffold in a patient with tracheomalacia // J Thorac Dis. 2016;8(11):3323– 3328. Doi: 10.21037/jtd.2016.10.53.Huang L, Wang L, He J, Zhao J, Zhong D, Yang G, Guo T, Yan X, Zhang L, Li D, Cao T, Li X. Tracheal suspension by using 3-dimensional printed personalized scaffold in a patient with tracheomalacia // J Thorac Dis. 2016;8(11):3323– 3328. Doi: 10.21037/jtd.2016.10.53.Athanasiou KA, Eswaramoorthy R, Hadidi P, Hu JC. Self-organization and the self-assembling process in tissue engineering // Annu Rev Biomed Eng. 2013;(15):115–136. Doi: 10.1146/annurev-bioeng-071812-152423.Athanasiou KA, Eswaramoorthy R, Hadidi P, Hu JC. Self-organization and the self-assembling process in tissue engineering // Annu Rev Biomed Eng. 2013;(15):115–136. Doi: 10.1146/annurev-bioeng-071812-152423.Go T, Jungebluth P, Baiguero S, Asnaghi A, Martorell J, Ostertag H, Mantero S, Birchall M, Bader A, Macchiarini P. Both epithelial cells and mesenchymal stem cell-derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs // J Thorac Cardiovasc Surg. 2010; 139(2):437–443. Doi: 10.1016/j.jtcvs.2009.10.002.Go T, Jungebluth P, Baiguero S, Asnaghi A, Martorell J, Ostertag H, Mantero S, Birchall M, Bader A, Macchiarini P. Both epithelial cells and mesenchymal stem cell-derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs // J Thorac Cardiovasc Surg. 2010; 139(2):437–443. Doi: 10.1016/j.jtcvs.2009.10.002.Dikina AD, Strobel HA, Lai BP, Rolle MW, Alsberg E. Engineered cartilaginous tubes for tracheal tissue replacement via self-assembly and fusion of human mesenchymal stem cell constructs // Biomaterials. 2015;(52):452–462. Doi: 10. 1016/j.biomaterials.2015.01.073.Dikina AD, Strobel HA, Lai BP, Rolle MW, Alsberg E. Engineered cartilaginous tubes for tracheal tissue replacement via self-assembly and fusion of human mesenchymal stem cell constructs // Biomaterials. 2015;(52):452–462. Doi: 10. 1016/j.biomaterials.2015.01.073.

The authors declare that there are no conflicts of interest present.