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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microcirculation</journal-id><journal-title-group><journal-title xml:lang="ru">Регионарное кровообращение и микроциркуляция</journal-title><trans-title-group xml:lang="en"><trans-title>Regional blood circulation and microcirculation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-6655</issn><issn pub-type="epub">2712-9756</issn><publisher><publisher-name>Academician I.P. Pavlov First St. Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1682-6655-2022-21-2-64-71</article-id><article-id custom-type="elpub" pub-id-type="custom">microcirculation-1074</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ (ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ)</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES (EXPERIMENTAL INVESTIGATIONS)</subject></subj-group></article-categories><title-group><article-title>Особенности гемодинамики каудальной полой вены крыс в различные возрастные периоды</article-title><trans-title-group xml:lang="en"><trans-title>Rats caudal vena cava hemodynamics features in different age periods</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андреева</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Andreeva</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Андреева Ирина Владимировна – д-р мед. наук, профессор кафедры урологии с курсом хирургических болезней, ФГБОУ ВО РязГМУ Минздава России, зав. отделением функциональной и ультразвуковой диагностики; руководитель НИР «Влияние физиологических факторов на функциональную адаптацию центральной, портальной и органной гемодинамики»</p><p>390026, Россия, г. Рязань, ул. Высоковольтная, д. 7</p></bio><bio xml:lang="en"><p>Andreeva Irina V. – Doctor of Medical Sciences, Professor, Professor of the Department of Urology with a course of surgical diseases; Chief of Dept. of Functional and Ultrasound Diagnostics of Ryazan City Clinical hospital of emergency medical care, Head of research «The influence of physiological factors on the functional adaptation of central, portal and organ hemodynamics»,</p><p>7, Vysokovoltnaya str., Ryazan, Russia, 390026</p></bio><email xlink:type="simple">prof.andreeva.irina.2012@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Телия</surname><given-names>В. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Telia</surname><given-names>V. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Телия Владимир Демуриевич – соискатель кафедры физиологии, ФГБОУ ВО РязГМУ Минздава России, врач – ортопедтравматолог, врач ультразвуковой диагностики травматологического и приемного отделения</p><p>390026, Россия, г. Рязань, ул. Высоковольтная, д. 7</p></bio><bio xml:lang="en"><p>Teliya Vladimir D. – Graduate student of the Department of Physiology; Doctor orthopedic traumatologist, Doctor of ultrasound diagnostics of the Traumatology and Reception Department of Central Clinical Hospital «Russian railways-Medicine»</p><p>7, Vysokovoltnaya str., Ryazan, Russia, 390026</p></bio><email xlink:type="simple">stroncy_872@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Устарова</surname><given-names>М. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Ustarova</surname><given-names>M. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Устарова Марина Гаджиевна – соискатель кафедры физиологии, ФГБОУ ВО РязГМУ Минздава России, врач-рентгенолог, врач ультразвуковой диагностики</p><p>390026, Россия, г. Рязань, ул. Высоковольтная, д. 7</p></bio><bio xml:lang="en"><p>Ustarova Marina G. – Graduate student of the Department of Physiology of the Ryazan State Medical University Radiologist, Doctor of ultrasound diagnostics</p><p>7, Vysokovoltnaya str., Ryazan, Russia, 390026</p></bio><email xlink:type="simple">somniferum@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Рязанский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ryazan State Medical University named after Academician I. P. Pavlov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>05</day><month>07</month><year>2022</year></pub-date><volume>21</volume><issue>2</issue><fpage>64</fpage><lpage>71</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Андреева И.В., Телия В.Д., Устарова М.Г., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Андреева И.В., Телия В.Д., Устарова М.Г.</copyright-holder><copyright-holder xml:lang="en">Andreeva A.I., Telia V.D., Ustarova M.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.microcirc.ru/jour/article/view/1074">https://www.microcirc.ru/jour/article/view/1074</self-uri><abstract><sec><title>Введение</title><p>Введение. Одним из перспективных направлений исследования возрастных особенностей гемодинамики печени является изучение кровотока в воротной и каудальной полой венах, а также в собственной печеночной артерии крыс.</p><p>Цель – определить качественные и количественные показатели гемодинамики в каудальной полой вене у лабораторных крыс различного пола и возраста.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Исследование проведено на 60 беспородных крысах обоего пола массой 120–270 г, разделенных на три возрастные группы. В первую группу вошло 20 крыс в возрасте 1 месяца, во вторую – 20 крыс в возрасте 6–12 месяцев и в третью – 20 крыс в возрасте более 18–24 месяцев. Изучение качественных и количественных показателей гемодинамики в каудальной полой вене выполняли с помощью ультразвуковых сканеров под золетил-ксилазиновым наркозом. Цифровые данные обрабатывали методами вариационной статистики.</p></sec><sec><title>Результаты</title><p>Результаты. У всех животных направление кровотока в каудальной полой вене было антеградным. Спектр кровотока различался по количеству, форме зубцов и фазности, у большинства животных был трехфазным, что не зависело от пола и возраста животных. Диаметр вены не зависел от пола. В I и II возрастных группах выявлено преобладание показателя объемной скорости кровотока в каудальной полой вене у самцов, по сравнению с самками, в пределах 10 % (R=0,98 и R=0,37 соответственно), в III возрастной группе взаимосвязь статистически не значима (R=–0,03). Диаметр и максимальная систолическая скорости кровотока в каудальной полой вене незначительно (в пределах 3 %) увеличились с возрастом животных (R=0,64 и R=0,43 соответственно). Показатель объемной скорости кровотока с увеличением возраста уменьшился в пределах 4 % (R=0,42).</p></sec><sec><title>Заключение</title><p>Заключение. Спектр кровотока в каудальной полой вене крыс отличался количеством, формой зубцов и фазностью, у большинства животных был трехфазным. У всех животных направление кровотока было антеградным. Зависимости фазности спектра от пола и возраста животных не выявлено. Статистически значимой зависимости диаметра и показателей линейной скорости кровотока от пола не выявлено. Объемная скорость кровотока была незначительно больше у самцов (в пределах 10 %) по сравнению с самками. Диаметр и максимальная систолическая скорость кровотока незначительно (в пределах 3 %) увеличились с возрастом животных. Показатель объемной скорости кровотока с увеличением возраста уменьшился в пределах 4 %.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Liver hemodynamics age-related features studying is promising area of portal and caudal vena cava and hepsatic artery of rats hemodynamics exploration.</p><p>Aim was to determine qualitative and quantitative hemodynamic paremeters of the laboratory rats caudal vena cava of different genders and ages.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study was conducted on 60 mongrel rats (males and females, 120–170 g) divided into three age groups. The first group included 20 rats aged 1 month, the second – 20 rats aged 6–12 months and the third – 20 rats aged more than 18–24 months. The study of caudal vena cava qualitative and quantitative hemodynamic parameters was performed by ultrasound scanners. Animals were anaesthesized by zoletil-xylazine. Digital data were processed by methods of variational statistics.</p></sec><sec><title>Results</title><p>Results. All animals showed the antegrade caudal vena cava blood flow. The spectrum of blood flow differed in the number, shape of teeth and phase. The most animals showed three-phase spectrum not depend on the animals gender and age. The diameter of the vein did not depend on the gender. In the I and II age groups, the predominance of the volumetric blood flow rate in the CPV in males compared with females was within 10 % (R=0.98 and R=0.37, respectively), in the III age group, the relationship was not statistically significant (R=–0.03). The diameter and maximum systolic blood flow velocity in the caudal vena cava increased slightly (within 3 %) with the age of the animals (R=0.64 and R=0.43, respectively). Volumetric blood flow rate decreased within 4 % with increasing age (R=0.42).</p></sec><sec><title>Conclusion</title><p>Conclusion. The spectrum of rats caudal vena cava blood flow differed in the number, shape of waves and phase. In most animals it was three-phase. In all animals the direction of blood flow was antegrade. The phase of the spectrum was not affected by the animals gender and age. There was no statistically significant dependence of the diameter and linear velocity of blood flow on the gender. The volumetric blood flow rate was slightly higher in males (within 10 %) compared to females. The diameter and the maximum systolic blood flow velocity increased slightly (within 3 %) with the age of the animals. The indicator of the volumetric blood flow rate decreased within 4 % with increasing age.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>печень</kwd><kwd>гемодинамика</kwd><kwd>каудальная полая вена</kwd><kwd>ультразвуковое дуплексное сканирование</kwd><kwd>допплерометрия</kwd><kwd>крысы различного пола и возраста</kwd></kwd-group><kwd-group xml:lang="en"><kwd>liver</kwd><kwd>hemodynamics</kwd><kwd>caudal vena cava</kwd><kwd>ultrasound duplex scanning</kwd><kwd>dopplerometry</kwd><kwd>rats of different genders and ages</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kalinin AL. The morphological and pathophysiological features of the liver in elderly patients // Health and Ecology Issues. 2016;(1):13–17. (In Russ.). Doi: 10.51523/2708-6011.2016-13-1-3.</mixed-citation><mixed-citation xml:lang="en">Kalinin AL. 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