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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microcirculation</journal-id><journal-title-group><journal-title xml:lang="ru">Регионарное кровообращение и микроциркуляция</journal-title><trans-title-group xml:lang="en"><trans-title>Regional blood circulation and microcirculation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-6655</issn><issn pub-type="epub">2712-9756</issn><publisher><publisher-name>Academician I.P. Pavlov First St. Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1682-6655-2022-21-2-72-79</article-id><article-id custom-type="elpub" pub-id-type="custom">microcirculation-1075</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRIEF SURVEY</subject></subj-group></article-categories><title-group><article-title>Нетипичный случай ишемической митральной недостаточности: патогенетически обоснованное лечение</article-title><trans-title-group xml:lang="en"><trans-title>Atypical case of ischemic mitral regurgitation: pathogenetically based treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крылов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Krylov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Крылов Владислав Викторович – врач – сердечно-сосудистый хирург кардиохирургического отделения для взрослых и отделения экстренной и плановой консультативной медицинской помощи</p><p>129110, Россия, Москва, ул. Щепкина, д. 61/2</p></bio><bio xml:lang="en"><p>Krylov Vladislav V. – cardiovascular surgeon of the adult’s cardiovascular surgery department and emergency and routine counseling department</p><p>61/2, Shepkina str., Moscow, Russia, 129110</p></bio><email xlink:type="simple">malus5@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Государственное бюджетное учреждение здравоохранения Московской области «Московский областной научно-исследовательский клинический институт им. М. Ф. Владимирского»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>M. F. Vladimirsky Moscow Regional Research and Clinical Institute «MONIKI»</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>05</day><month>07</month><year>2022</year></pub-date><volume>21</volume><issue>2</issue><fpage>72</fpage><lpage>79</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Крылов В.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Крылов В.В.</copyright-holder><copyright-holder xml:lang="en">Krylov V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.microcirc.ru/jour/article/view/1075">https://www.microcirc.ru/jour/article/view/1075</self-uri><abstract><sec><title>Введение</title><p>Введение. Эволюция представлений об ишемической дисфункции митрального клапана под влиянием фундаментальных и экспериментальных исследований последних лет привела к изменению роли митральных створок в патогенезе ишемической митральной недостаточности (ИМН) как статичного компонента митрального аппарата, в особенности при хронической ишемии миокарда.</p></sec><sec><title>Описание случая</title><p>Описание случая. Описан клинический случай остро возникшей ИМН в результате отрыва хорды ЗСМК у пациента, имеющего анамнез ишемической болезни сердца неуточненной давности без развития острого коронарного синдрома и перенесенного ранее инфаркта миокарда, отражающий все этапы диагностического поиска и результаты хирургического лечения.</p></sec><sec><title>Заключение</title><p>Заключение. При выполнении реконструктивной коррекции ИМН следует учитывать возможность обратного ремоделирования створок при условии устранения триггерного фактора, которым является ишемия миокарда, что диктует необходимость полноценной и достаточной реваскуляризации миокарда левого желудочка, что в сочетании с коррекцией всех морфофункциональных изменений митрального аппарата позволяет гарантировать отсутствие резидуальной и рецидивной митральной недостаточности.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. The evolution of the study of mitral valve ischemic dysfunction influenced by fundamental and experimental research in recent years has led to a change of mitral leaflets role as a static component of the mitral valve in the pathogenesis of ischemic mitral regurgitation especially in the chronic myocardial ischemia.</p></sec><sec><title>Objective</title><p>Objective. We report the clinical case of acute ischemic mitral regurgitation as a result of a chord rupture of the PML in a patient with unspecified duration of coronary artery disease without acute coronary syndrome and previous myocardial infarction including all stages of the diagnostic search and the results of surgical treatment.</p></sec><sec><title>Conclusion</title><p>Conclusion. While performing reconstructive correction of the ischemic mitral regurgitation the possibility of reverse remodeling of the leaflets should be considered in case of removal the myocardial ischemia triggering factor. And therefore it is necessary to perform a full and adequate myocardial revascularization that combined with a full correction of all morphofunctional mitral valve changes guarantees the freedom from residual and recurrent mitral regurgitation.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ишемическая болезнь сердца</kwd><kwd>митральный клапан</kwd><kwd>ишемическая митральная недостаточность</kwd><kwd>ишемическая дисфункция створок</kwd><kwd>пролапс митрального клапана</kwd><kwd>хирургическая коррекция ишемической митральной недостаточности</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ischemic heart disease</kwd><kwd>mitral valve</kwd><kwd>ischemic mitral regurgitation</kwd><kwd>ischemic leaflet dysfunction</kwd><kwd>mitral valve prolapse</kwd><kwd>surgical treatment of ischemic mitral regurgitation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Руденко С. 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