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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microcirculation</journal-id><journal-title-group><journal-title xml:lang="ru">Регионарное кровообращение и микроциркуляция</journal-title><trans-title-group xml:lang="en"><trans-title>Regional blood circulation and microcirculation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-6655</issn><issn pub-type="epub">2712-9756</issn><publisher><publisher-name>Academician I.P. Pavlov First St. Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1682-6655-2022-21-3-33-39</article-id><article-id custom-type="elpub" pub-id-type="custom">microcirculation-1099</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ (КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ)</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES (CLINICAL INVESTIGATIONS)</subject></subj-group></article-categories><title-group><article-title>Значение площади поясничной мышцы в качестве показателя неблагоприятных исходов после транскатетерного протезирования аортального клапана</article-title><trans-title-group xml:lang="en"><trans-title>Role of psoas muscle area as an indicator of adverse outcomes after transcatheter aortic valve implantation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5157-3755</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куликов</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulikov</surname><given-names>D. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Куликов Дмитрий Игоревич – врач РХМДиЛ</p><p>194017, Санкт-Петербург, пр. Тореза, д. 72, лит. А</p></bio><bio xml:lang="en"><p>Kulikov Dmitriy I. – X-ray surgeon, Saint-Petersburg city clinical hospital of Russian Scientific Academy</p><p>72, Toreza str., Saint Petersburg, 194017</p></bio><email xlink:type="simple">dockulikov@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1447-3509</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зверев</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zverev</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зверев Дмитрий Анатольевич – канд. мед. наук, доцент кафедры общей хирургии; зав. отделением РХМДиЛ</p><p>197341, Санкт-Петербург, ул. Аккуратова, д. 2</p><p>238312, Калининградская область, Гурьевский р-н, пос. Родники, ш. Калининградское, д. 4</p></bio><bio xml:lang="en"><p>ZverevDmitriy A. – Ph. D., Associate Professor at the Department of General Surgery</p><p>2, Akkuratova str., Saint Petersburg, 197341</p><p>4, Kaliningrad Highway, Rodniki, Guryevsky district, Kaliningrad region, 238312</p></bio><email xlink:type="simple">dmitry_zverev@yahoo.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4273-5086</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Стрелков</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Strelkov</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Стрелков Дмитрий Алексеевич – младший научный сотрудник, врач РХМДиЛ</p><p>197341, Санкт-Петербург, ул. Аккуратова, д. 2</p></bio><bio xml:lang="en"><p>Strelkov Dmitriy A. – Research Assistant, X-ray surgeon</p><p>2, Akkuratova str., Saint Petersburg, 197341</p></bio><email xlink:type="simple">dmitristrelkov111@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1540-5337</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пищугин</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Pishchugin</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пищугин Александр Сергеевич – аспирант, врач РХМДиЛ</p><p>197341, Санкт-Петербург, ул. Аккуратова, д. 2</p></bio><bio xml:lang="en"><p>Pishchugin Aleksandr S. – Postgraduate, X-ray surgeon</p><p>2, Akkuratova str., Saint Petersburg, 197341</p></bio><email xlink:type="simple">pischuginalexander@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение здравоохранения «Санкт-Петербургская клиническая больница Российской академии наук»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint-Petersburg city clinical hospital of Russian Scientific Academy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное учреждение «Федеральный центр высоких медицинских технологий» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V. A. Almazov National Medical Research Centre; Kaliningrad Federal Cardiovascular Surgery Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V. A. Almazov National Medical Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>12</day><month>10</month><year>2022</year></pub-date><volume>21</volume><issue>3</issue><fpage>33</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Куликов Д.И., Зверев Д.А., Стрелков Д.А., Пищугин А.С., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Куликов Д.И., Зверев Д.А., Стрелков Д.А., Пищугин А.С.</copyright-holder><copyright-holder xml:lang="en">Kulikov D.I., Zverev D.A., Strelkov D.A., Pishchugin A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.microcirc.ru/jour/article/view/1099">https://www.microcirc.ru/jour/article/view/1099</self-uri><abstract><p>Введение. Хрупкость пациента, важнейшим компонентом которой является мышечная гипотрофия, имеет значение при определении тактики лечения сердечно-сосудистых заболеваний в связи со снижением физиологического резерва. Объективная оценка уровня дистрофических изменений общей мышечной массы возможна с помощью определения площади поперечного сечения поясничной мышцы (PMA). Целью исследования явился поиск взаимосвязи площади поясничной мышцы (PMA) с неблагоприятными исходами после транскатетерного протезирования аортального клапана (TAVI). Материалы и методы. В исследование включены 51 пациент с критическим симптоматическим аортальным стенозом и высокими факторами рисков по EuroScore II и STS. Исследование представляет собой ретроспективный, одноцентровой анализ взаимосвязи PMA по результатам предоперационной мультиспиральной компьютерной томографии с неблагоприятными исходами после TAVI. PMA рассчитывалась как среднее значение площади левой и правой поясничных мышц. Измерения PMA затем были нормализованы по площади поверхности тела пациента (m2) и представлены как индекс поясничной мышцы (iPMА, см2/м2). Результаты. Средний возраст пациентов составил 78,2±9,3 года, из них 29 (56,9 %) женщин. Так как iPMA не имел нормального распределения, были проанализированы медианные значения: медиана iPMA для мужчин – 4,35 см2/м2 и для женщин – 3,55 см2/м2. В ходе проведенного нами исследования было установлено, что iPMA был ниже у пациентов с ранним неблагоприятным исходом (3,21±0,42 vs 5,47±0,43 см2/м2; р=0,017). Пациентам с низким iPMA (62,8 %) потребовалась более длительная госпитализация, также низкий iPMA можно считать предиктором более высоких затрат ресурсов клиники (р=0,056). Заключение. Наше исследование продемонстрировало, что iPMA, рассчитанный с помощью компьютерной томографии, является простым и объективным предиктором осложнений в раннем послеоперационном периоде и длительной госпитализации после TAVI и, как следствие, более высоких затрат ресурсов клиники.</p></abstract><trans-abstract xml:lang="en"><p>Introduction. Patient frailty, having muscle hypotrophy as the main component, is important in determining the treatment tactics of cardiovascular diseases due to a decrease in the physiological reserve. An objective assessment of dystrophic changes level in the total muscle mass is possible by measurig the cross-sectional area of the psoas muscle (PMA). Аim was to determine if the psoas muscle area (PMA) could predict adverse outcomes and to investigate its utility in patients after transcatheter aortic valve implantation (TAVI). Materials and methods. The study included 51 patients with critical symptomatic aortic stenosis and high risk factors according to EuroScore II and STS. The study is a retrospective, single-centre analysis of the association of PMA from preoperative multislice computed tomography with adverse outcomes after TAVI. PMA was calculated as the average area of the left and right psoas. PMA measurements were then normalized to the patient’s body surface area (m2) and showed as psoas muscle index (iPMA; cm2/m2). Results. The mean age of the patients was 78.2±9.3 years, where 29 (56.9 %) were women. Since iPMA was not normally distributed, median values were analyzed: median iPMA for men 4.35 cm2/m2 and for women 3.55 cm2/m2. In our study, we found that iPMA was lower in patients with an early adverse outcome than in patients without an early adverse outcome (3.21±0.42 vs 5.47±0.43 cm2/m2; p=0.017). Patients with low iPMA (62.8 %) required longterm hospitalization, and low iPMA can be considered a predictor of higher hospital resource costs (p=0.056). Conclusion. Our study demonstrated that computed tomography-calculated iPMA is a simple and objective predictor of early postoperative complications and prolonged hospital stay after TAVI, and consequently higher hospital resource costs.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хрупкость пациента</kwd><kwd>мышечная гипотрофия</kwd><kwd>площадь поперечного сечения поясничной мышцы (PMA)</kwd><kwd>транскатетерное протезирование аортального клапана</kwd></kwd-group><kwd-group xml:lang="en"><kwd>patient frailty</kwd><kwd>muscular wasting</kwd><kwd>psoas muscle cross-sectional area (PMA)</kwd><kwd>transcatheter aortic valve implantation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Leon MB, Smith CR, Mack M, Miller DC, Moses JW, Svensson LG, Tuzcu EM, Webb JG, Fontana GP, Makkar RR, Brown DL, Block PC, Guyton RA, Pichard AD, Bavaria JE, Herrmann HC, Douglas PS, Petersen JL, Akin JJ, Anderson WN, Wang D, Pocock S; PARTNER Trial Investigators. 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