microcirculationРегионарное кровообращение и микроциркуляцияRegional blood circulation and microcirculation1682-66552712-9756Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1682-6655-2023-22-3-19-33microcirculation-1212Research ArticleОБЗОРЫREVIEWSЭндотелий и старение: механизмы формирования сенесцентного фенотипа эндотелиальных клетокEndothelium and aging: mechanisms for formation of senescence associated phenotype of endothelial cellshttps://orcid.org/0000-0002-2624-6450ВласоваТ. И.VlasovaT. I.

Власова Татьяна Ивановна – д-р мед. наук, доцент, зав. кафедрой нормальной и патологической физиологии

430000,  г. Саранск, ул. Большевистская, д. 68

Vlasova Tatyana I. – MD, Associate Professor; Head, Department of Normal and Pathological Physiology

68, Bolshevistskaya str., Saransk, 430000

v.t.i@bk.ruhttps://orcid.org/0000-0003-4760-2394ПетрищевН. Н.PetrishchevN. N.

Петрищев Николай Николаевич – д-р мед. наук, профессор, профессор кафедры патофизиологии с курсом клинической патофизиологии

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8

Petrishchev Nikolay N. – MD, Honored Scientist of the Russian Federation, Dr. Sci. (Med.); Professor, Department of Pathophysiology; Head, Center for Laser Medicine ; Head, Russian Association for Regional Hemodynamics and Microcirculation 

 6-8, L’va Tolstogo str., Saint Petersburg, 197022

lazmed@yandex.ruhttps://orcid.org/0000-0002-6951-7599ВласовТ. Д.VlasovT. D.

Власов Тимур Дмитриевич – д-р мед. наук, профессор, зав. кафедрой патофизиологии с курсом клинической патофизиологии

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8

Vlasov Timur D. – MD, Professor, Head of the Department of Pathophysiology with a course of clinical pathophysiology

6-8, L’va Tolstogo str., Saint Petersburg, 197022

tvlasov@yandex.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Национальный исследовательский Мордовский государственный университет имени Н. П. Огарева»РоссияOgaryov National Research Mordovia State UniversityRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияPavlov UniversityRussian Federation2023161020232231933Copyright © Власова Т.И., Петрищев Н.Н., Власов Т.Д., 20232023Власова Т.И., Петрищев Н.Н., Власов Т.Д.Vlasova T.I., Petrishchev N.N., Vlasov T.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.microcirc.ru/jour/article/view/1212

Проблема клеточного старения является ключевой в определении механизмов старения организма в целом и развития возраст-ассоциированных заболеваний. Изучение факторов, вызывающих активацию программы клеточного старения эндотелия, является важным аспектом расширения превентивных anti-age технологий, направленных на замедление данного процесса и снижения риска развития заболеваний сердечно-сосудистой системы. В данном обзоре освещены современные представления о факторах старения эндотелиальных клеток с акцентом на роль эндогенных изменений гомеостаза эндотелиальных клеток, их предшественниц и микроокружения. В качестве предполагаемых механизмов старения эндотелия рассмотрены дисрегуляция клеточного цикла, митохондриальная дисфункция, изменение гомеостаза белков, истощение пула эндотелиальных клеток-предшественников, а также изменение регуляции программ апоптоза и аутофагии. 

The problem of cellular aging is a key one in determining the mechanisms of organism aging and the development of ageassociated diseases. The study of the cause factors of the endothelial cellular aging program activation is an important aspect of expanding preventive anti-age technologies aimed at slowing down this process and reducing the risk of cardiovascular system diseases. This review highlights current ideas about the factors of endothelial cell aging and the role of endogenous changes in the homeostasis of endothelial cells, their precursors, and the microenvironment. Cell cycle dysregulation, mitochondrial dysfunction, changes in protein homeostasis, depletion of the endothelial progenitor cells pool and changes in the regulation of apoptosis and autophagy programs are considered as mechanisms of endothelium aging.

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The authors declare that there are no conflicts of interest present.