microcirculationРегионарное кровообращение и микроциркуляцияRegional blood circulation and microcirculation1682-66552712-9756Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1682-6655-2024-23-2-4-14microcirculation-1304Research ArticleОБЗОРЫREVIEWSСовременный взгляд на роль перицитов в микроциркуляцииModern view on the role of pericytes in the microcirculationhttps://orcid.org/0000-0003-1491-3882МихайловП. В.MikhailovP. V.

Михайлов Павел Валентинович – д-р биол. наук, доцент кафедры спортивных дисциплин

150000, г. Ярославль, ул. Республиканская, д. 108/1

Mikhailov Pavel V. – Doctor of Biological Sciences, Associate Professor, Department of Sports Disciplines

108/1, Respublikanskaya str., Yaroslavl, 150000

mpv.yar@yandex.ruhttps://orcid.org/0000-0002-5502-9164МуравьевА. В.MuravevA. V.

Муравьев Алексей Васильевич – д-р биол. наук, профессор кафедры медико-биологических основ спорта 

150000, г. Ярославль, ул. Республиканская, д. 108/1

Muravev Aleksei V. – Doctor of Biological Sciences, Professor, Department of Medical and Biological Foundations of Sports

108/1, Respublikanskaya str., Yaroslavl, 150000

alexei.47@mail.ruhttps://orcid.org/0000-0001-9521-4017ТихомироваИ. А.TikhomirovaI. A.

Тихомирова Ирина Александровна – д-р биол. наук, профессор, зав. кафедрой медицины, биологии, теории и методики обучения биологии

150000, г. Ярославль, ул. Республиканская, д. 108/1

Tikhomirova Irina A. – Doctor of Biological Sciences, Professor, Head, Department of Medicine, Biology, Theory and Methods of  Teaching Biology

108/1, Respublikanskaya str., Yaroslavl, 150000

tikhom-irina@yandex.ruhttps://orcid.org/0000-0002-3269-2262ОсетровИ. А.OsetrovI. A.

Осетров Игорь Александрович – канд. биол. наук, доцент кафедры спортивных дисциплин

150000, г. Ярославль, ул. Республиканская, д. 108/1

Osetrov Igor A. – Candidate (PhD) of Biological Sciences, Associate Professor, Department of Sports Disciplines

108/1, Respublikanskaya str., Yaroslavl, 150000

igos@yandex.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Ярославский государственный педагогический университет им. К. Д. Ушинского»РоссияUshinsky Yaroslavl State Pedagogical UniversityRussian Federation202425062024232414Copyright © Михайлов П.В., Муравьев А.В., Тихомирова И.А., Осетров И.А., 20242024Михайлов П.В., Муравьев А.В., Тихомирова И.А., Осетров И.А.Mikhailov P.V., Muravev A.V., Tikhomirova I.A., Osetrov I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.microcirc.ru/jour/article/view/1304

Перициты были обнаружены примерно 150 лет назад, и их название можно перевести, как обхватывающие клетки. Расположение перицитов на наружной стенке капилляров, наличие отростков и тесный контакт с соседними эндотелиальными клетками привели к предположению об их роли в регуляции капиллярного кровотока. За последние годы появилось большое количество публикаций, подтверждающих эту гипотезу. Более того, накопленные к настоящему времени данные свидетельствуют о том, что перициты являются многофункциональными клетками и играют заметную, а иногда и ключевую роль в таких процессах, как регуляция тканевого кровотока, функционирование гематоэнцефалического барьера, ангиогенез и ремоделирование сосудов, иммунные реакции. Показано участие перицитов в патогенезе ряда заболеваний и продемонстрирована потенциальная возможность использования их в качестве мишеней для терапевтических воздействий

Pericytes were discovered about 150 years ago and their name can be translated as enveloping cells. The location of pericytes on the outer wall of capillaries, the presence of appendages and close contact with neighboring endothelial cells of the capillaries resulted in the hypothesis of their participation in the capillary blood flow control. Over the last years, a large number of publications confirming this hypothesis have appeared. Moreover, the data accumulated to date indicate that pericytes are multifunctional cells and play a significant and sometimes key role in such processes as regulation of tissue blood flow, functioning of the blood-brain barrier, angiogenesis, vascular remodeling, and immune responses. The participation of pericytes in the pathogenesis of certain diseases has been shown and the potential for their use as targets for therapeutic effects has been demonstrated.

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The authors declare that there are no conflicts of interest present.