microcirculationРегионарное кровообращение и микроциркуляцияRegional blood circulation and microcirculation1682-66552712-9756Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1682-6655-2024-23-2-52-59microcirculation-1315Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИ (КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ)ORIGINAL ARTICLES (CLINICAL INVESTIGATIONS)Особенности морфо-функциональных характеристик тромбоцитов у женщин с ранней и поздней преэклампсиейPeculiarities of morpho-functional characteristics of platelets in women with early and late preeclampsiahttps://orcid.org/0000-0002-1725-8505КлычеваМ. М.KlychevaM. M.

Клычева Майя Михайловна – канд. биол. наук, научный сотрудник лаборатории клинической биохимии и генетики

153045,  г. Иваново, ул. Победы, д. 20

Klycheva Maya M. – Candidate (PhD) of Biological Sciences, Researcher, Laboratory of Clinical Biochemistry and Genetics

20, Pobedy str., Ivanovo, 153045

maya.klycheva@yandex.ruhttps://orcid.org/0000-0002-0828-6547ПановаИ. А.PanovaI. A.

Панова Ирина Александровна – д-р мед. наук, проф., заведующий отделом акушерства и гинекологии 

153045,  г. Иваново, ул. Победы, д. 20

Panova Irina A. – MD, Prof., Head, Department of Obstetrics and Gynecology

20, Pobedy str., Ivanovo, 153045

ia_panova@mail.ruhttps://orcid.org/0000-0003-1545-7655НазаровС. Б.NazarovS. B.

Назаров Сергей Борисович – д-р мед. наук, проф., заместитель директора по научной работе

153045,  г. Иваново, ул. Победы, д. 20

Nazarov Sergei B. – MD, Prof., Deputy Director for Research

20, Pobedy str., Ivanovo, 153045

sergey@nazarov.wshttps://orcid.org/0000-0001-5772-9271КузьменкоГ. Н.KuzmenkoG. N.

Кузьменко Галина Николаевна – д-р мед. наук, ведущий научный сотрудник лаборатории клинической биохимии и генетики

153045,  г. Иваново, ул. Победы, д. 20

Kuzmenko Galina N. – MD, Leading Researcher, Laboratory of Clinical Biochemistry and Genetics

20, Pobedy str., Ivanovo, 153045

kuzmenko_gnk@mail.ruhttps://orcid.org/0000-0002-8776-7743СадовР. И.SadovR. I.

Садов Руслан Игоревич – канд. мед. наук, врач приемного отделения гинекологической клиники 

153045,  г. Иваново, ул. Победы, д. 20

Sadov Ruslan I. – Candidate (PhD) of Medical Sciences, Doctor, Admission Department, Gynecological Clinic

20, Pobedy str., Ivanovo, 153045

mail4Ruslan@mail.ruhttps://orcid.org/0000-0003-1836-3523ПоповаИ. Г.PopovaI. G.

Попова Ирина Геннадьевна – канд. мед. наук, старший научный сотрудник лаборатории клинической биохимии и генетики

153045,  г. Иваново, ул. Победы, д. 20

Popova Irina G. – PhD in Medical sciences, research officer laboratory of clinical biochemistry and genetics

20, Pobedy str., Ivanovo, 153045

i_g_popova@mail.ruФедеральное государственное бюджетное учреждение «Ивановский научно-исследовательский институт материнства и детства имени В. Н. Городкова» Министерства здравоохранения Российской ФедерацииРоссияGorodkov Ivanovo Research Institute of Maternity and ChildhoodRussian Federation2024290620242325259Copyright © Клычева М.М., Панова И.А., Назаров С.Б., Кузьменко Г.Н., Садов Р.И., Попова И.Г., 20242024Клычева М.М., Панова И.А., Назаров С.Б., Кузьменко Г.Н., Садов Р.И., Попова И.Г.Klycheva M.M., Panova I.A., Nazarov S.B., Kuzmenko G.N., Sadov R.I., Popova I.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.microcirc.ru/jour/article/view/1315

Введение. При преэклампсии (ПЭ) существенно изменяется система гемостаза, в том числе и тромбоцитарное звено. Цель работы состояла в выявлении особенностей морфо-функциональных характеристик тромбоцитов у женщин с ранней и поздней ПЭ. Материал и методы. Основную группу составили 26 женщин с ранней ПЭ и 46 женщин с поздней ПЭ. Контрольная группа состояла из женщин с нормальной беременностью без гипертензивных расстройств, из них 17 – в сроке гестации 260–336 недель и 42 – в сроке 340–394 недели. На гематологическом анализаторе ADVIA 2120i оценивались концентрация тромбоцитов (PLT), ширина распределения тромбоцитов по объему (PDW), средний объем тромбоцитов (MPV), концентрация больших форм тромбоцитов (Large PLT), процентное содержание больших форм тромбоцитов от общего числа тромбоцитов (%LP), средняя концентрация компонентов тромбоцитов (MPC), средняя сухая масса тромбоцитов (MPM). Результаты. У женщин с ранней ПЭ повышены индексы PDW, MPV, LargePlt, %LP и MPM по сравнению с женщинами с нормальной беременностью в сроке до 34 недель. У пациенток с поздней ПЭ отмечены более низкая PLT и более высокие PDW, %LP, MPC, MPM по сравнению с женщинами с нормальной беременностью после 34 недель. При поздней ПЭ снижена PLT и повышены PDW, %LP и MPM по сравнению с ранней ПЭ. Заключение. Выявленные изменения тромбоцитарных индексов у женщин с ПЭ, независимо от срока ее начала, косвенно указывают на усиление тромбопоэза и высокую функциональную активность молодых тромбоцитов. Однако механизмы, повышающие активацию тромбоцитов при ранней и поздней преэклампсии, различаются.

Introduction. In preeclampsia (PE), the hemostasis system, including the platelet component, changes significantly. The purpose of the work was to identify the peculiarities of the morpho-functional characteristics of platelets in women with early and late PE. Material and methods. The main group consisted of 26 women with early PE and 46 women with late PE. The control group consisted of women with normal pregnancies without hypertensive disorders, of whom 17 were at a gestational age of 260–336 weeks and 42 were at a gestational age of 340–394 weeks. The ADVIA 2120i hematology analyzer was used to evaluate platelet concentration (PLT), platelet distribution width (PDW), mean platelet volume (MPV), concentration of large platelets (Large PLT), percentage of large platelets from the total number of platelets (%LP), mean platelet component concentration (MPC), mean dry platelet mass (MPM). Results. Women with early PE have increased PDW, MPV, LargePlt, %LP and MPM indices compared to women with normal pregnancies up to 34 weeks. Female patients with late PE had lower PLT and higher PDW, %LP, MPC, MPM compared to women with normal pregnancies after 34 weeks. In late PE, PLT is reduced and PDW, %LP and MPM are increased compared to early PE. Conclusion. The detected changes in platelet indices in women with PE, regardless of the period of its onset, indirectly indicate increased thrombopoiesis and high functional activity of young platelets. However, the mechanisms that increase platelet activation in early and late preeclampsia differ.

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The authors declare that there are no conflicts of interest present.