microcirculationРегионарное кровообращение и микроциркуляцияRegional blood circulation and microcirculation1682-66552712-9756Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1682-6655-2024-23-3-12-18microcirculation-1339Research ArticleОБЗОРЫREVIEWSРоль регуляторов фосфорно-кальциевого обмена в развитии кардиоренального синдромаRole of phosphorus-calcium metabolism regulators in cardiorenal syndrome developmenthttps://orcid.org/0000-0002-0581-7285СмирноваН. Н.SmirnovaN. N.

Смирнова Наталия Николаевна – д-р мед. наук, профессор, зав. кафедрой педиатрии,

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8.

Smirnova Natalia N. – MD, Professor, Head, Department of Pediatrics,

6-8, L’va Tolstogo street, Saint Petersburg, 197022.

nephro-uro-kids@mail.ruhttps://orcid.org/0000-0003-2054-3419КуприенкоН. Б.KuprienkoN. B.

Куприенко Наталья Борисовна – канд. мед. наук, доцент,

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8.

Kuprienko Natalia B. – Candidate (PhD) of Medical Sciences, Associate Professor, Department of Pediatrics, 

6-8, L’va Tolstogo street, Saint Petersburg, 197022.

n-b-k@bk.ruФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияPavlov UniversityRussian Federation2024081020242331218Copyright © Смирнова Н.Н., Куприенко Н.Б., 20242024Смирнова Н.Н., Куприенко Н.Б.Smirnova N.N., Kuprienko N.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.microcirc.ru/jour/article/view/1339

Кардиоренальный синдром – сложное состояние, относящееся к категории острой или хронической патологии почек, вызывающих сердечно-сосудистые заболевания, и, наоборот, острых или хронических заболеваний сердца, провоцирующих дисфункцию почек. Взаимосвязь патологии сердечно-сосудистой системы и почек обусловлена общностью факторов риска патологии обеих систем. В последние годы доказана связь регуляторов минерального обмена – витамина D, паратиреотропного гормона, эндокринных факторов роста фибробластов 19, 21, 23, белка Клото – с развитием сердечной недостаточности,мерцательной аритмии, гипертрофии левогожелудочка сердца, а также с прогрессированием хронической болезни почек. Ранними маркерами хронической болезни почек и сердечно-сосудистых заболеваний признаны повышенный уровень фактора роста фибробластов-23 и снижение растворимой фракции белка Клото в плазме крови. Дальнейшее изучение влияния регуляторов минерального обмена на кардиоренальный синдром создает новое направление в лечении сердечно-сосудистых заболеваний и хронической болезни почек.

Cardiorenal syndrome is a complex condition that belongs to the category of acute or chronic kidney pathology that causes cardiovascular disease, and, conversely, acute or chronic heart disease that provokes kidney dysfunction. The relationship between the pathology of the cardiovascular system and the kidneys is due to the commonality of risk factors for the pathology of both systems. In recent years, the link between regulators of mineral metabolism - vitamin D, parathyroid hormone, endocrine growth factors of fibroblasts 19,21,23, Klotho protein with the development of heart failure, atrial fibrillation, left ventricular hypertrophy, as well as the progression of chronic kidney disease has been proven. The increased levels of fibroblast growth factor-23 and a decrease in the soluble fraction of Klotho protein in plasma are recognized as early markers of chronic kidney disease and cardiovascular disease. Further study of the influence of mineral exchange regulators on cardiorenal syndrome creates a new direction in the treatment of cardiovascular diseases and chronic kidney disease.

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The authors declare that there are no conflicts of interest present.