microcirculationРегионарное кровообращение и микроциркуляцияRegional blood circulation and microcirculation1682-66552712-9756Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1682-6655-2025-24-1-4-13microcirculation-1393Research ArticleОБЗОРЫREVIEWSБиотехнологические подходы в кардиологии на основе модулирования механизмов с участием интерлейкина-1Biotechnological approaches in cardiology based on modulation of mechanisms involving interleukin-1ПроцакЕ. С.ProtsakE. S.

Процак Егор Сергеевич – младший научный сотрудник 

197341, Санкт-Петербург, ул. Аккуратова, д. 2 

Protsak Egor S. – Junior Researcher 

2, Akkuratova str., Saint Petersburg, 197341 

egorprotsak@yandex.ruБорщевЮ. Ю.BorshchevYu. Yu.

Борщев Юрий Юрьевич – канд. биол. наук, ведущий научный сотрудник, зав. лабораторией токсикологии 

197341, Санкт-Петербург, ул. Аккуратова, д. 2 

197758, Санкт-Петербург, пос. Песочный, ул. Ленинградская, д. 68 

Borshchev Yuri Yu. – Candidate (PhD) of Biological Sciences, Head, Department of Toxicology

2, Akkuratova str., Saint Petersburg, 197341 

68, Leningradskaya str., Saint Petersburg, pos. Pesochny`j, 197758 

niscon@mail.ruГалагудзаМ. М.GalagudzaM. M.

Галагудза Михаил Михайлович – д-р мед. наук, профессор, член-корр. раН, директор ИЭМ 

197341, Россия, Санкт-Петербург, ул. Аккуратова, д. 2 

197022, Россия, Санкт-Петербург, ул. Льва Толстого, д. 6-8 

Galagudza Michael M. – Doctor of Medicine, Prof., Corresponding Member of the Russian Academy of Sciences, Director

2, Akkuratova str., Saint Petersburg, 197341 

6-8, L’va Tolstogo str., Saint Petersburg, Russia, 197022 

galagoudza@mail.ruФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research CentreRussian FederationФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации ; Федеральное государственное бюджетное учреждение «Научно-исследовательский институт онкологии имени Н. Н. Петрова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research Centre ; Petrov National Medical Research Center of OncologyRussian FederationФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации ; Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research Centre ; Pavlov UniversityRussian Federation202509042025241413Copyright © Процак Е.С., Борщев Ю.Ю., Галагудза М.М., 20252025Процак Е.С., Борщев Ю.Ю., Галагудза М.М.Protsak E.S., Borshchev Y.Y., Galagudza M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.microcirc.ru/jour/article/view/1393

Сердечно-сосудистые заболевания (ССЗ) занимают первое место в структуре смертности и инвалидизации во всем мире. Одну из важнейших ролей в прогрессировании ССЗ играет хроническое воспаление низкой степени активности. В обзоре рассматривается роль цитокинов семейства интерлейкина-1 (IL-1) в развитии ССЗ. Цитокины семейства IL-1 играют важную роль в прогрессировании атеросклероза, развитии инфаркта миокарда (ИМ), хронической сердечной недостаточности (ХСН). В обзоре представлены данные о механизмах действия IL-1, эффективности анти-IL-1-препаратов в рамках профилактики ССЗ. Рассмотрена возможность использования изменения состава кишечной микробиоты как метода воздействия на уровень IL-1.

Cardiovascular diseases (CVD) are the leading cause of death and disability worldwide. Low-grade chronic inflammation plays a major role in the progression of CVD. The review examines the role of interleukin-1 (IL-1) family cytokines in the development of CVD. IL-1 family cytokines play an important role in the progression of atherosclerosis, the development of myocardial infarction (MI), and chronic heart failure (CHF). The review presents data on the mechanisms of IL-1 action and the effectiveness of anti-IL-1 drugs in the prevention of CVD. Also, in this review, we consider the possibility of using changes in the composition of intestinal microbiota as a method of influencing the level of IL-1.

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The authors declare that there are no conflicts of interest present.