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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microcirculation</journal-id><journal-title-group><journal-title xml:lang="ru">Регионарное кровообращение и микроциркуляция</journal-title><trans-title-group xml:lang="en"><trans-title>Regional blood circulation and microcirculation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-6655</issn><issn pub-type="epub">2712-9756</issn><publisher><publisher-name>Academician I.P. Pavlov First St. Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1682-6655-2025-24-1-101-109</article-id><article-id custom-type="elpub" pub-id-type="custom">microcirculation-1405</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURES</subject></subj-group></article-categories><title-group><article-title>Анализ механизмов функциональной реализации морфологических различий строения сосудов гемомикроциркуляторного русла</article-title><trans-title-group xml:lang="en"><trans-title>Analysis of mechanisms of functional implementation of morphological differences in the structure of hemomicrocirculatory vessels</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Милюков</surname><given-names>В. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Milyukov</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Милюков Владимир Ефимович – д-р мед. наук, профессор кафедры анатомии человека</p><p>117997, Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Milyukov Vladimir E. – MD, Professor, Department of Anatomy</p><p>1, Ostrovityanova str., Moscow, 117997</p></bio><email xlink:type="simple">milyucov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бартош</surname><given-names>Н. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Bartosh</surname><given-names>N. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бартош Николай Олегович – д-р мед. наук, профессор кафедры топографической анатомии и оперативной хирургии</p><p>117997, Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Bartosh Nikolay O. – MD, Professor, Department of Topographic Anatomy and Operative Surgery</p><p>1, Ostrovityanova str., Moscow, 117997</p></bio><email xlink:type="simple">no.bartosh@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-2180-1855</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аверин</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Averin</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аверин Дамир Александрович – студент 3-го курса, Институт мировой медицины</p><p>117997, Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Averin Damir A. – 3rd year Student, Institute of World Medicine</p><p>1, Ostrovityanova str., Moscow, 117997</p></bio><email xlink:type="simple">averin.damir@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное автономное образовательное учреждение высшего образования «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>09</day><month>04</month><year>2025</year></pub-date><volume>24</volume><issue>1</issue><fpage>101</fpage><lpage>109</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Милюков В.Е., Бартош Н.О., Аверин Д.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Милюков В.Е., Бартош Н.О., Аверин Д.А.</copyright-holder><copyright-holder xml:lang="en">Milyukov V.E., Bartosh N.O., Averin D.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.microcirc.ru/jour/article/view/1405">https://www.microcirc.ru/jour/article/view/1405</self-uri><abstract><p>В современном понимании системы обеспечения сосудистой трофики гемомикроциркуляторное русло представляет собой последовательное соединение артериол, прекапилляров, капилляров, посткапилляров и венул, упорядоченных по своему расположению в тканях, а также наличие артериоло-венулярных анастомозов. Дифференцировка различных звеньев микроциркуляторного русла основывается не только на величине просвета сосудов, но и на особенностях строения их стенок и выполняемых функций. Основным обменным звеном системы кровообращения человека является капиллярное русло, в котором в настоящее время описано наличие трех типов капилляров, различие которых устанавливается особенностями строения их стенок. При этом морфологические различия строения стенки капилляров определяют существенные отличия в выполняемых ими функциях, что вызывает ряд критических замечаний по обоснованности объединения капилляров в один вид сосудов только на основе отсутствия различий диаметра. Кроме того, при формировании объективной морфофункциональной оценки организации гемомикроциркуляторного русла органа и/или ткани требуется оценка топографоанатомических закономерностей архитектоники и взаиморасположения различных типов капилляров в сосудистой сети органов и тканей, которые могут быть определены с помощью современных методов морфометрии. Результатами дальнейших исследований этой направленности могут стать новые знания о закономерностях организации кровоснабжения, позволяющие детализировать роль различных микрососудов в организации микрогемодинамики и обменных процессов в органах и тканях в норме и при патологии, а также найти важное прикладное использование в разработке новых методов селективной доставки лекарственных препаратов к очагу патологического процесса при различных заболеваниях человека.</p></abstract><trans-abstract xml:lang="en"><p>In the modern understanding of the system of vascular trophic support, the haemomicrocirculatory bed is a sequential connection of arterioles, precapillaries, capillaries, postcapillaries and venules, ordered by their location in tissues, as well as the presence of arteriolo-venular anastomoses. Differentiation of various links of the microcirculatory bed is based not only on the size of the vessel lumen, but also on the peculiarities of the structure of their walls and the functions performed. The main metabolic link of the human circulatory system is the capillary bed, in which the presence of three types of capillaries is currently described, the distinction of which is established by the peculiarities of the structure of their walls. At the same time, morphological differences of capillary wall structure determine essential differences in their functions, which causes a number of critical comments on the validity of uniting capillaries into one type of vessels only in the absence of diameter differences. In addition, when forming an objective morphofunctional assessment of the organization of the haemomicrocirculatory bed of an organ and/or tissue, it is necessary to evaluate topographic-anatomical regularities of the architectonics and mutual location of different types of capillaries in the vascular network of organs and tissues, which can be determined using modern methods of morphometry. The results of further research in this direction can become new knowledge about the regularities of blood supply organization, allowing to detail the role of various microvessels in the organization of microhemodynamics and metabolic processes in organs and tissues in norm and pathology, as well as find an important applied use in the development of new methods of selective drug delivery to the focus of pathological process in various human diseases.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>типы капилляров</kwd><kwd>органноспецифичность</kwd><kwd>эндотелиальная стенка</kwd><kwd>адресная доставка</kwd><kwd>фармакотерапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>types of capillaries</kwd><kwd>organospecificity</kwd><kwd>endothelial wall</kwd><kwd>targeted delivery</kwd><kwd>pharmacotherapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ивонин А. 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