References

microcirculation

Регионарное кровообращение и микроциркуляция

Regional blood circulation and microcirculation

1682-66552712-9756

Academician I.P. Pavlov First St. Petersburg State Medical University

10.24884/1682-6655-2018-17-1-5-12

microcirculation-145

Research Article

ОБЗОРЫ

REVIEWS

Постишемическое невосстановление кровотока: механизмы и терапевтические мишени

The no-reflow phenomenon: mechanisms and therapeutic targets

Галагудза

М. М.

Galagudza

M. M.

galagoudza@mail.ru

Сонин

Д. Л.

Sonin

D. L.

sonin_dl@almazovcentre.ru

Почкаева

Е. И.

Pochkaeva

E. I.

pochkaeva_ei@almazovcentre.ru

Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research Centre of the Ministry of Healthcare of the Russian Federation; Pavlov First Saint Petersburg State Medical UniversityRussian Federation

Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный университет»РоссияAlmazov National Medical Research Centre of the Ministry of Healthcare of the Russian Federation; St. Petersburg State UniversityRussian Federation

2018

30032018

171512

2018

Галагудза М.М., Сонин Д.Л., Почкаева Е.И.

Galagudza M.M., Sonin D.L., Pochkaeva E.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.microcirc.ru/jour/article/view/145

Феномен постишемического невосстановления кровотока заключается в отсутствии полноценной перфузии миокарда на уровне микроциркуляторного русла после устранения причины, вызвавшей окклюзию коронарной артерии. Выделяют два основных механизма возникновения феномена невосстановления кровотока, возникающих у пациентов с инфарктом миокарда после первичной чрескожной ангиопластики: проявления ишемического-реперфузионного повреждения микроциркуляторного русла миокарда и эмболизация дистального артериального русла фрагментами тромба и атеросклеротической бляшки. В обзоре описаны факторы, которые способствуют появлению феномена постишемического невосстановления кровотока, механизмы его появления, принципы диагностики и терапевтические мишени.

The phenomenon of «no-reflow» refers to a state of myocardial tissue hypoperfusion or absence of perfusion after eliminating the cause of the occlusion of the coronary artery. Two main pathogenetic mechanisms may contribute to the development of no-reflow phenomenon after primary percutaneous coronary intervention in patients with myocardial infarction: ischemic-reperfusion injury of the microcirculatory vessels and embolization of the distal arterial bed with fragments of thrombus and atherosclerotic plaque. In this review, we describe the pathophysiological mechanisms of no-reflow, risk factors for no-reflow phenomenon, the principles of diagnosis and therapeutic targets.

феномен невосстановления кровотокаинфаркт миокардаишемически-реперфузионное повреждениемикроваскулярная обструкциячрескожное коронарное вмешательствопосткондиционированиекардиопротекцияno-reflow phenomenonmyocardial infarctionischemia-reperfusion injurymicrovascular obstructionpercutaneous coronary interventionpostconditioningcardioprotection

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The authors declare that there are no conflicts of interest present.