microcirculationРегионарное кровообращение и микроциркуляцияRegional blood circulation and microcirculation1682-66552712-9756Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1682-6655-2018-17-4-microcirculation-157Research ArticleОБЗОРЫREVIEWSНовые данные о патогенезе преэклампсииNew data on the pathogenesis of preeclampsiaРезникВ. А.ReznikV. A.

канд. мед. наук, доцент кафедры акушерства и гинекологии с курсом гинекологии детского возраста,

194100, Санкт-Петербург, ул.Литовская, д. 2

MD, PhD, Associate Professor, Department of Obstetrics and Gynecology,

194100, St. Petersburg, Litovskaya street, 2

vitaliy-reznik@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Educational Institution of Higher Education «Saint-Petersburg State Pediatric Medical University» of Ministry of Healthcare of the Russian FederationRussian Federation201811122018174410Copyright © Резник В.А., 20192019Резник В.А.Reznik V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.microcirc.ru/jour/article/view/157

В настоящее время преэклампсия является одной из наиболее актуальных проблем в акушерстве и гинекологии. Значимость данной патологии формируют как высокая частота ее встречаемости, так и существенное патологическое воздействие, оказываемое на организм матери и плода. При этом патогенез преэклампсии весьма сложен и представляет собой комплекс взаимосвязанных и дополняющих друг друга патофизиологических и биохимических реакций. Одним из основных механизмов развития преэклампсии является избыточный синтез антиангиогенных факторов, способствующих, кроме всего прочего, повышению активности ряда веществ, обладающих вазоконстрикторным действием. Эти изменения приводят к формированию плацентарной недостаточности и развитию клинической картины заболевания. Среди важнейших веществ, способствующих формированию избыточного неконтролируемого вазоспазма, выделяют эндогенные дигиталисподобные факторы (ЭДФ), регулирующие активность Na+ /К+ -ATФазы. При этом основное значение придается ЭДФ, структурно представленным буфадиенолидами. Классическим представителем этой группы является маринобуфагенин. Он способен избирательно блокировать α-1-изоформу Na+ /К+ -ATФазы, широко представленную в почечных канальцах, тем самым обладая свойствами выраженного вазоконстриктора.

Currently, preeclampsia is one of the most significant problems in obstetrics and gynecology. The significance of this pathology is determined by its high prevalence and pathological impact on the organism of both mother and fetus. The pathogenesis of preeclampsia is very complex, involving many different interrelated, complementary pathophysiological and biochemical reactions. One of the main mechanisms of preeclampsia development is the excessive synthesis of antiangiogenic factors that, among other effects, contribute to increased activity of a number of substances with vasoconstrictor action. These changes lead to the formation of placental insufficiency and the development of clinically overt disease. Among the most important substances that contribute to the formation of excessive uncontrolled vasospasm are endogenous digitalis-like factors (EDFs) which regulate the activity of Na+/K+-ATPase. The most important structural class of EDFs is represented by bufadienolides. The classic representative of this group is marinobufagenin. It selectively blocks the α-1 isoform of Na+/K+-ATPase, widely represented in the renal tubules thereby having the properties of potent.

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The authors declare that there are no conflicts of interest present.