References

microcirculation

Регионарное кровообращение и микроциркуляция

Regional blood circulation and microcirculation

1682-66552712-9756

Academician I.P. Pavlov First St. Petersburg State Medical University

10.24884/1682-6655-2018-17-2-4-11

microcirculation-159

Research Article

ОБЗОРЫ

REVIEWS

Нейропротективное действие орексиновой системы при ишемическом инсульте

Neuroprotective activity of orexin system in ischemic stroke

Фильченко

И. А.

Filchenko

I. A.

Iriina6994@gmail.com

Свиряев

Ю. В.

Sviryaev

Yu. V.

yusvyr@yandex.ru

Власов

Т. Д.

Vlasov

T. D.

tvlasov@yandex.ru

Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное учреждение науки «Институт эволюционной физиологии и биохимии имени И. М. Сеченова» Российской академии наук; Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Educational Institution of Higher Education «Pavlov First Saint Petersburg State Medical University»; Sechenov institute of evolutionary physiology and biochemistry Russian academy of sciences; Federal State Budgetary Institution «Almazov National Medical Research Centre» of the Ministry of Health of the Russian FederationRussian Federation

Федеральное государственное бюджетное учреждение науки «Институт эволюционной физиологии и биохимии имени И. М. Сеченова» Российской академии наук; Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияSechenov institute of evolutionary physiology and biochemistry Russian academy of sciences; Federal State Budgetary Institution «Almazov National Medical Research Centre» of the Ministry of Health of the Russian FederationRussian Federation

Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Educational Institution of Higher Education «Pavlov First Saint Petersburg State Medical University»; Federal State Budgetary Institution «Almazov National Medical Research Centre» of the Ministry of Health of the Russian FederationRussian Federation

2018

30062018

172411

2018

Фильченко И.А., Свиряев Ю.В., Власов Т.Д.

Filchenko I.A., Sviryaev Y.V., Vlasov T.D.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.microcirc.ru/jour/article/view/159

Изучение защитного потенциала орексинергической системы является важным направлением поиска стратегий снижения повреждения головного мозга при ишемическом инсульте. Установлен цитопротективный эффект орексинов при гипоксическом повреждении, обусловленный антиоксидантными, противовоспалительными, антиапоптотическими свойствами пептидов, а также их способностью усиливать пролиферацию и нормализовывать метаболизм. Влияние орексинов на память и болевой синдром при ишемическом инсульте изучено недостаточно, но общность патогенеза данных нарушений и механизмов действия орексинов указывает на возможности применения орексинов для коррекции указанных осложнений. Дальнейшие исследования защитного эффекта орексинов могут стать шагом на пути создания новых подходов к лечению ишемического инсульта.

The protective potential of orexin system is a field of interest in the search of the new methods to diminish brain damage in ischemic stroke. The cytoprotective potential of orexins in hypoxic damage is associated with their antioxidant, anti-inflammatory and anti-apoptotic properties and with their ability to activate proliferation and normalize metabolism. Even though today little is known about the role of orexins in memory and pain in ischemic stroke, the common features of the pathogenesis of these disruptions and the mechanisms of orexin-associated protection could suggest the opportunity to use of orexins for correction of these complications following ischemic stroke. Further studies of the orexin-associated neuroprotection could become the further step on the way to the new therapeutic approaches in ischemic stroke.

орексиныинсультнейропротекцияишемия головного мозгаorexinstrokeneuroprotectionbrain ischemia

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The authors declare that there are no conflicts of interest present.