<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microcirculation</journal-id><journal-title-group><journal-title xml:lang="ru">Регионарное кровообращение и микроциркуляция</journal-title><trans-title-group xml:lang="en"><trans-title>Regional blood circulation and microcirculation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-6655</issn><issn pub-type="epub">2712-9756</issn><publisher><publisher-name>Academician I.P. Pavlov First St. Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1682-6655-2018-17-3-71-79</article-id><article-id custom-type="elpub" pub-id-type="custom">microcirculation-202</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ (КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ)</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES (CLINICAL INVESTIGATIONS)</subject></subj-group></article-categories><title-group><article-title>Методы оптической биопсии и их перспективы применения для интраоперационного анализа тканевого метаболизма и микроциркуляции крови в мини-инвазивной хирургии</article-title><trans-title-group xml:lang="en"><trans-title>Optical biopsy methods and their prospects of application for intraoperative analysis of tissue metabolism and blood microcirculation in minimally invasive surgery</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кандурова</surname><given-names>К. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kandurova</surname><given-names>K. Y.</given-names></name></name-alternatives><email xlink:type="simple">kandkseniya@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дрёмин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dremin</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">dremin_viktor@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жеребцов</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zherebtsov</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">zherebzow@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Альянов</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Alyanov</surname><given-names>A. L.</given-names></name></name-alternatives><email xlink:type="simple">tantoras@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мамошин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mamoshin</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">dr.mamoshin@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Потапова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Potapova</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">potapova_ev_ogu@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дунаев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dunaev</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">inohvat@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мурадян</surname><given-names>В. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Muradyan</surname><given-names>V. F.</given-names></name></name-alternatives><email xlink:type="simple">clinic@orel.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сидоров</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sidorov</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">victor.v.sidorov@gmail.com</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крупаткин</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Krupatkin</surname><given-names>A. I.</given-names></name></name-alternatives><email xlink:type="simple">aikrup@mail.ru</email><xref ref-type="aff" rid="aff-6"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Орловский государственный университет имени И. С. Тургенева»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education «Orel State University named after I. S. Turgenev»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Орловский государственный университет имени И. С. Тургенева»; Aston University</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education «Orel State University named after I. S. Turgenev»; Aston University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Орловский государственный университет имени И. С. Тургенева»; Бюджетное учреждение здравоохранения Орловской области «Орловская областная клиническая больница»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education «Orel State University named after I. S. Turgenev»; Orel Regional Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Бюджетное учреждение здравоохранения Орловской области «Орловская областная клиническая больница»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Orel Regional Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>OOO НПП «ЛАЗМА»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>SPE «LAZMA» Ltd</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр травматологии и ортопедии имени Н. Н. Приорова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education «N. N. Priorov National Medical research center of traumatology and orthopaedics» of Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2018</year></pub-date><volume>17</volume><issue>3</issue><fpage>71</fpage><lpage>79</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кандурова К.Ю., Дрёмин В.В., Жеребцов Е.А., Альянов А.Л., Мамошин А.В., Потапова Е.В., Дунаев А.В., Мурадян В.Ф., Сидоров В.В., Крупаткин А.И., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Кандурова К.Ю., Дрёмин В.В., Жеребцов Е.А., Альянов А.Л., Мамошин А.В., Потапова Е.В., Дунаев А.В., Мурадян В.Ф., Сидоров В.В., Крупаткин А.И.</copyright-holder><copyright-holder xml:lang="en">Kandurova K.Y., Dremin V.V., Zherebtsov E.A., Alyanov A.L., Mamoshin A.V., Potapova E.V., Dunaev A.V., Muradyan V.F., Sidorov V.V., Krupatkin A.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.microcirc.ru/jour/article/view/202">https://www.microcirc.ru/jour/article/view/202</self-uri><abstract><p>Статья представляет собой обзор различных методов и подходов, используемых в настоящее время в рамках понятия «оптическая биопсия» при исследовании перфузии кровью и метаболизма тканей внутренних органов человека. Целью являлось изучение особенностей и областей применения данных методов и оценка возможностей дальнейшего приложения для задач интраоперационного получения данных в мини-инвазивной хирургии органов гепатопанкреатодуоденальной зоны. Предварительные экспериментальные исследования были проведены методом флуоресцентной спектроскопии при патологиях общего желчного протока, желчного пузыря и печени. Полученные в работе данные показывают перспективы применения данного метода, а также послужат основой дальнейших исследований с целью получения дополнительных диагностических критериев.</p></abstract><trans-abstract xml:lang="en"><p>The work is devoted to review the various methods and approaches currently used within the framework of the concept of optical «biopsy» in the study of blood perfusion and metabolism of human organs tissues. The purpose of the review was to study the features and areas of application of these methods and to assess further application possibilities for intraoperative data acquisition in minimally invasive surgery of hepatopancreatoduodenal organs. Preliminary experimental studies were performed with fluorescence spectroscopy method in pathologies of the common bile duct, gallbladder and liver. The data obtained in the work show the prospects for this method application, and serve as the basis for further research in order to obtain additional diagnostic criteria.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>оптическая биопсия</kwd><kwd>спектроскопия</kwd><kwd>визуализация</kwd><kwd>флуоресцентная спектроскопия</kwd><kwd>миниинвазивная хирургия</kwd><kwd>optical biopsy</kwd><kwd>spectroscopy</kwd><kwd>imaging</kwd><kwd>fluorescence spectroscopy</kwd><kwd>minimally invasive surgery</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Арутюнян А. В., Черданцев Д. В., Салмин В. В. и др. Интраоперационная лазер-индуцированная флуоресцентная спектроскопия при экспериментальном панкреатите // Сибир. мед. обозрение. - 2012 - № 5. - С. 20-24. [Arutyunyan AV, Cherdantsev DV Salmin VV, et al. Intraoperative laser-induced fluorescence spectroscopy in experimental pancreatitis. Sibirskoye meditsinskoye obozreniye. 2012;5:20-24 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Арутюнян А. В., Черданцев Д. В., Салмин В. В. и др. Интраоперационная лазер-индуцированная флуоресцентная спектроскопия при экспериментальном панкреатите // Сибир. мед. обозрение. - 2012 - № 5. - С. 20-24. [Arutyunyan AV, Cherdantsev DV Salmin VV, et al. Intraoperative laser-induced fluorescence spectroscopy in experimental pancreatitis. Sibirskoye meditsinskoye obozreniye. 2012;5:20-24 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Волков И. А., Фриго Н. В., Знаменская Л. Ф. и др. Применение конфокальной лазерной сканирующей микроскопии в биологии и медицине // Вестн. дерматол. и венерол. - 2014. - № 1. - С. 17-24. doi: 10.25208/0042-4609-2014-0-1-3-13. [Volkov IA, Frigo NV Znamenskaya LF i dr. Application of Confocal Laser Scanning Microscopy in Biology and Medicine. Vestnik dermatologii i venerologii. 2014;(1):17-24 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Волков И. А., Фриго Н. В., Знаменская Л. Ф. и др. Применение конфокальной лазерной сканирующей микроскопии в биологии и медицине // Вестн. дерматол. и венерол. - 2014. - № 1. - С. 17-24. doi: 10.25208/0042-4609-2014-0-1-3-13. [Volkov IA, Frigo NV Znamenskaya LF i dr. Application of Confocal Laser Scanning Microscopy in Biology and Medicine. Vestnik dermatologii i venerologii. 2014;(1):17-24 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ганиева Д. К. Патология гепатопанкреатодуоденальной системы и факторы риска ее развития // Молодой ученый. - 2016. - № 22. - С. 97-99 [Ganieva DK. Pathology of hepatopancreatoduodenal system and risk factors for its development. Molodoy uchenyy. 2016;22: 97-99 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Ганиева Д. К. Патология гепатопанкреатодуоденальной системы и факторы риска ее развития // Молодой ученый. - 2016. - № 22. - С. 97-99 [Ganieva DK. Pathology of hepatopancreatoduodenal system and risk factors for its development. Molodoy uchenyy. 2016;22: 97-99 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ермолов А. С. и др. Диагностика и лечение острого панкреатита. - М.: Видар, 2013. [Ermolov AS, et al. Diagnostika i lechenie ostrogo pankreatita. M.: Vidar, 2013 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Ермолов А. С. и др. Диагностика и лечение острого панкреатита. - М.: Видар, 2013. [Ermolov AS, et al. Diagnostika i lechenie ostrogo pankreatita. M.: Vidar, 2013 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Тучин В. В. Лазеры и волоконная оптика в биомедицинских исследованиях. - М.: ФИЗМАТЛИТ, 2010. [Tuchin VV. Lazery i volokonnaya optika v biomedicinskih issledovaniyah. M.: FIZMATLIT, 2010 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Тучин В. В. Лазеры и волоконная оптика в биомедицинских исследованиях. - М.: ФИЗМАТЛИТ, 2010. [Tuchin VV. Lazery i volokonnaya optika v biomedicinskih issledovaniyah. M.: FIZMATLIT, 2010 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Тучин В. В. Оптическая медицинская диагностика: в 2 т. Т. 1. - М.: Физматлит, 2007. [Tuchin VV. Opticheskaya medicinskaya diagnostika: v 2 t. T. 1. M.: Fizmatlit, 2007].</mixed-citation><mixed-citation xml:lang="en">Тучин В. В. Оптическая медицинская диагностика: в 2 т. Т. 1. - М.: Физматлит, 2007. [Tuchin VV. Opticheskaya medicinskaya diagnostika: v 2 t. T. 1. M.: Fizmatlit, 2007].</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Дронова О. Б., Третьяков А. А., Мищенко А. Н. и др. Исследование возможностей лазер-индуцированной аутофлуоресценции в диагностике пищевода Барретта // Сибир. онколог. журн. - 2008. - Т. 28 - № 4. - С. 11-16. [Dronova OB, Tretyakov AA, Mishchenko AN, et al. Laser induced autofluorescence of normal and metaplastic epithelium of esophagogastric transition at gastroesophageal reflux disease. Sibirskiy onkologicheskiyzhurnal. 2008;4(28):11-16 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Дронова О. Б., Третьяков А. А., Мищенко А. Н. и др. Исследование возможностей лазер-индуцированной аутофлуоресценции в диагностике пищевода Барретта // Сибир. онколог. журн. - 2008. - Т. 28 - № 4. - С. 11-16. [Dronova OB, Tretyakov AA, Mishchenko AN, et al. Laser induced autofluorescence of normal and metaplastic epithelium of esophagogastric transition at gastroesophageal reflux disease. Sibirskiy onkologicheskiyzhurnal. 2008;4(28):11-16 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Andrews PM, Wang HW, Guo H, et al. Optical coherence tomography of the aging kidney. Experimental and Clinical Transplantation 2016;14(6):617-622. doi:10.6002/ect. 2015.0212.</mixed-citation><mixed-citation xml:lang="en">Andrews PM, Wang HW, Guo H, et al. Optical coherence tomography of the aging kidney. Experimental and Clinical Transplantation 2016;14(6):617-622. doi:10.6002/ect. 2015.0212.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Apolikhina LA, Denisova ED, Bulgakova NN, Kuzmin SG, Vorozhtsov GN. Fluorescence detection and photodynamic therapy of human papilloma virus associated diseases of female genital organs. Proceedings of the 6th International Congress of the World Association of Laser Therapy, 2006:59-61.</mixed-citation><mixed-citation xml:lang="en">Apolikhina LA, Denisova ED, Bulgakova NN, Kuzmin SG, Vorozhtsov GN. Fluorescence detection and photodynamic therapy of human papilloma virus associated diseases of female genital organs. Proceedings of the 6th International Congress of the World Association of Laser Therapy, 2006:59-61.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Bartolome F, Abramov AY. Measurement of mitochondrial NADH and FAD autofluorescence in live cells. Methods Molecular Biology, 2015:1264:263-270.</mixed-citation><mixed-citation xml:lang="en">Bartolome F, Abramov AY. Measurement of mitochondrial NADH and FAD autofluorescence in live cells. Methods Molecular Biology, 2015:1264:263-270.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Bulgakova NN, Kazachkina NI, Sokolov VV, et al. Local fluorescence spectroscopy and detection of malignancies using laser excitation at various wavelengths. Laser Physics 2006;16(5):889-895. doi:10.1134/S1054660X06050227.</mixed-citation><mixed-citation xml:lang="en">Bulgakova NN, Kazachkina NI, Sokolov VV, et al. Local fluorescence spectroscopy and detection of malignancies using laser excitation at various wavelengths. Laser Physics 2006;16(5):889-895. doi:10.1134/S1054660X06050227.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Bulgakova N, Sokolov V, Telegina L, et al. Study of laser-induced autofluorescence emission spectra from normal and malignant bronchial epithelium. Photonics and Lasers in Medicine 2013;2(2):93-99. doi:10.1134/S1054660X06050227.</mixed-citation><mixed-citation xml:lang="en">Bulgakova N, Sokolov V, Telegina L, et al. Study of laser-induced autofluorescence emission spectra from normal and malignant bronchial epithelium. Photonics and Lasers in Medicine 2013;2(2):93-99. doi:10.1134/S1054660X06050227.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bulgakova N, Ulijanov R, Vereschagin K, et al. In vivo local fluorescence spectroscopy in PDD of superficial bladder cancer. Medical Laser Application 2009;24(4):247-255. doi: 10.1134/S1054660X06050227.</mixed-citation><mixed-citation xml:lang="en">Bulgakova N, Ulijanov R, Vereschagin K, et al. In vivo local fluorescence spectroscopy in PDD of superficial bladder cancer. Medical Laser Application 2009;24(4):247-255. doi: 10.1134/S1054660X06050227.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Buchner AM, Wallace MB. Endomicroscopy and Molecular Tools to Evaluate Inflammatory Bowel Disease. Gastrointestinal Endoscopy Clinics of North America 2016; 26(4):657-668. doi: 10.1016/j.giec.2016.06.002.</mixed-citation><mixed-citation xml:lang="en">Buchner AM, Wallace MB. Endomicroscopy and Molecular Tools to Evaluate Inflammatory Bowel Disease. Gastrointestinal Endoscopy Clinics of North America 2016; 26(4):657-668. doi: 10.1016/j.giec.2016.06.002.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Chance B, Williams GR. Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization. The Journal of biological chemistry. 1955;217(1):383-393.</mixed-citation><mixed-citation xml:lang="en">Chance B, Williams GR. Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization. The Journal of biological chemistry. 1955;217(1):383-393.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Chance B, Williamson JR, Jamieson D, et al. Properties and kinetics of reduced pyridine nucleotide fluorescence of the isolated and in vivo rat heart. Biochem J 1965;341:357-377.</mixed-citation><mixed-citation xml:lang="en">Chance B, Williamson JR, Jamieson D, et al. Properties and kinetics of reduced pyridine nucleotide fluorescence of the isolated and in vivo rat heart. Biochem J 1965;341:357-377.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Costello FE. Optical coherence tomography technologies: Which machine do you want to own? Journal of Neuro Ophthalmology 2014;34(SUPPL.3):3-9. doi: 10.1097/WNO.0000000000000161.</mixed-citation><mixed-citation xml:lang="en">Costello FE. Optical coherence tomography technologies: Which machine do you want to own? Journal of Neuro Ophthalmology 2014;34(SUPPL.3):3-9. doi: 10.1097/WNO.0000000000000161.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">De Los Santos C, Chang CW, Mycek MA, et al. FRAP, FLIM, and FRET: Detection and analysis of cellular dynamics on a molecular scale using fluorescence microscopy. Molecular Reproduction and Development 2015;82(7-8):587-604. doi: 10.1002/mrd.22501.</mixed-citation><mixed-citation xml:lang="en">De Los Santos C, Chang CW, Mycek MA, et al. FRAP, FLIM, and FRET: Detection and analysis of cellular dynamics on a molecular scale using fluorescence microscopy. Molecular Reproduction and Development 2015;82(7-8):587-604. doi: 10.1002/mrd.22501.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Dremin VV, Dunaev AV. How the melanin concentration in the skin affects the fluorescence-spectroscopy signal formation. Journal of Optical Technology (A Translation of Opticheskii Zhurnal) 2016;83(1):43-48. doi: 10.1364/JOT.83.000043.</mixed-citation><mixed-citation xml:lang="en">Dremin VV, Dunaev AV. How the melanin concentration in the skin affects the fluorescence-spectroscopy signal formation. Journal of Optical Technology (A Translation of Opticheskii Zhurnal) 2016;83(1):43-48. doi: 10.1364/JOT.83.000043.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Dremin VV, Zherebtsov EA, Rafailov IE, et al. The development of attenuation compensation models of fluorescence spectroscopy signals. 2015. Proceedings Vol. 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS); 99170Y. doi: 10.1117/12.2229451.</mixed-citation><mixed-citation xml:lang="en">Dremin VV, Zherebtsov EA, Rafailov IE, et al. The development of attenuation compensation models of fluorescence spectroscopy signals. 2015. Proceedings Vol. 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS); 99170Y. doi: 10.1117/12.2229451.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Dremin VV, Zherebtsov EA, Sidorov VV, et al. Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus. Journal of Biomedical Optics 2017;22(8). doi: 10.1117/1.JBO.22.8.085003.</mixed-citation><mixed-citation xml:lang="en">Dremin VV, Zherebtsov EA, Sidorov VV, et al. Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus. Journal of Biomedical Optics 2017;22(8). doi: 10.1117/1.JBO.22.8.085003.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Dunaev AV, Dremin VV, Zherebtsov EA, et al. Individual variability analysis of fluorescence parameters measured in skin with different levels of nutritive bloodflow. Medical Engineering and Physics. 2015;37(6):574-583. doi: 10.1016/j.medengphy.2015.03.011.</mixed-citation><mixed-citation xml:lang="en">Dunaev AV, Dremin VV, Zherebtsov EA, et al. Individual variability analysis of fluorescence parameters measured in skin with different levels of nutritive bloodflow. Medical Engineering and Physics. 2015;37(6):574-583. doi: 10.1016/j.medengphy.2015.03.011.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Eriksson S, Nilsson J, Lindell G, et al. Laser speckle contrast imaging for intraoperative assessment of liver microcirculation: A clinical pilot study. Medical Devices: Evidence and Research 2014;7(1):257-261. doi: 10.2147/MDER.S63393.</mixed-citation><mixed-citation xml:lang="en">Eriksson S, Nilsson J, Lindell G, et al. Laser speckle contrast imaging for intraoperative assessment of liver microcirculation: A clinical pilot study. Medical Devices: Evidence and Research 2014;7(1):257-261. doi: 10.2147/MDER.S63393.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Fercher AF, Briers JD. Flow visualization by means of single-exposure speckle photography. Optics Communications 1981;37(5):326-330. doi: 10.1016/0030-4018(81)90428-4.</mixed-citation><mixed-citation xml:lang="en">Fercher AF, Briers JD. Flow visualization by means of single-exposure speckle photography. Optics Communications 1981;37(5):326-330. doi: 10.1016/0030-4018(81)90428-4.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Fujiwara T, Kono S, Katakura K, et al. Evaluation of Brain Activity Using Near-infrared Spectroscopy in Inflammatory Bowel Disease Patients. Scientific Reports 2018;8(1). doi: 10.1038/s41598-017-18897-4.</mixed-citation><mixed-citation xml:lang="en">Fujiwara T, Kono S, Katakura K, et al. Evaluation of Brain Activity Using Near-infrared Spectroscopy in Inflammatory Bowel Disease Patients. Scientific Reports 2018;8(1). doi: 10.1038/s41598-017-18897-4.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Georgakoudi I, Feld MS. The combined use of fluorescence, reflectance, and light-scattering spectroscopy for evaluating dysplasia in Barrett’s esophagus. Gastrointestinal Endoscopy Clinics of North America 2004;14(3):519-537. doi: 10.1016/j.giec.2004.03.008.</mixed-citation><mixed-citation xml:lang="en">Georgakoudi I, Feld MS. The combined use of fluorescence, reflectance, and light-scattering spectroscopy for evaluating dysplasia in Barrett’s esophagus. Gastrointestinal Endoscopy Clinics of North America 2004;14(3):519-537. doi: 10.1016/j.giec.2004.03.008.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Georgakoudi I, Jacobson BC, Van Dam J, et al. Fluorescence, reflectance, and light-scattering spectroscopy for evaluating dysplasia in patients with Barrett’s esophagus. Gastroenterology 2001;120(7):1620-1629. doi: 10.1053/gast.2001.24842.</mixed-citation><mixed-citation xml:lang="en">Georgakoudi I, Jacobson BC, Van Dam J, et al. Fluorescence, reflectance, and light-scattering spectroscopy for evaluating dysplasia in patients with Barrett’s esophagus. Gastroenterology 2001;120(7):1620-1629. doi: 10.1053/gast.2001.24842.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ilic M, Ilic I. Epidemiology of pancreatic cancer. World Journal of Gastroenterology 2016;22(44):9694-9705. doi: 10.3748/wjg.v22.i44.9694.</mixed-citation><mixed-citation xml:lang="en">Ilic M, Ilic I. Epidemiology of pancreatic cancer. World Journal of Gastroenterology 2016;22(44):9694-9705. doi: 10.3748/wjg.v22.i44.9694.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kandurova K, Dremin V, Alyanov A, et al. Possibilities of application of fluorescence spectroscopy in minimally invasive surgery for analysis of abdominal cavity organs parhological processes. Book of Abstracts - Summer School on Optics &amp; Photonics, 2017:46.</mixed-citation><mixed-citation xml:lang="en">Kandurova K, Dremin V, Alyanov A, et al. Possibilities of application of fluorescence spectroscopy in minimally invasive surgery for analysis of abdominal cavity organs parhological processes. Book of Abstracts - Summer School on Optics &amp; Photonics, 2017:46.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Lee SY, Lloyd WR, Chandra M, et al. Characterizing human pancreatic cancer precursor using quantitative tissue optical spectroscopy. Biomedical Optics Express 2013;4(12):2828-2834. doi: 10.1364/BOE.4.002828.</mixed-citation><mixed-citation xml:lang="en">Lee SY, Lloyd WR, Chandra M, et al. Characterizing human pancreatic cancer precursor using quantitative tissue optical spectroscopy. Biomedical Optics Express 2013;4(12):2828-2834. doi: 10.1364/BOE.4.002828.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Lister T, Wright PA, Chappell PH. Optical properties of human skin. Journal of Biomedical Optics 2012;17(9). doi: 10.1117/1.JBO.17.9.090901.</mixed-citation><mixed-citation xml:lang="en">Lister T, Wright PA, Chappell PH. Optical properties of human skin. Journal of Biomedical Optics 2012;17(9). doi: 10.1117/1.JBO.17.9.090901.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Lopez JJ, Arain SA, Madder R, Parekh N, Shroff AR, Westerhausen D. Techniques and best practices for Optical coherence tomography: A practical manual for interventional cardiologists. Catheterization and Cardiovascular Interventions 2014;84(5):687-699. doi:10.1002/ccd.25500.</mixed-citation><mixed-citation xml:lang="en">Lopez JJ, Arain SA, Madder R, Parekh N, Shroff AR, Westerhausen D. Techniques and best practices for Optical coherence tomography: A practical manual for interventional cardiologists. Catheterization and Cardiovascular Interventions 2014;84(5):687-699. doi:10.1002/ccd.25500.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Mayevsky A. Mitochondrial function in vivo evaluated by NADH fluorescence. 2015: 1-276.</mixed-citation><mixed-citation xml:lang="en">Mayevsky A. Mitochondrial function in vivo evaluated by NADH fluorescence. 2015: 1-276.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Mayevsky A, Chance B. Oxidation-reduction states of NADH in vivo: From animals to clinical use. Mitochondrion 2007;7(5):330-339. doi: 10.1016/j.mito.2007.05.001.</mixed-citation><mixed-citation xml:lang="en">Mayevsky A, Chance B. Oxidation-reduction states of NADH in vivo: From animals to clinical use. Mitochondrion 2007;7(5):330-339. doi: 10.1016/j.mito.2007.05.001.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Pantanowitz L, Preffer F, Wilbur DC. Advanced imaging technology applications in cytology. Diagnostic Cytopathology 2018. doi: 10.1002/dc.23898.</mixed-citation><mixed-citation xml:lang="en">Pantanowitz L, Preffer F, Wilbur DC. Advanced imaging technology applications in cytology. Diagnostic Cytopathology 2018. doi: 10.1002/dc.23898.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Parthasarathy AB, Weber EL, Richards LM, et al. Laser speckle contrast imaging of cerebral bloodflow in humans during neurosurgery: A pilot clinical study. Journal of Biomedical Optics 2010;15(6). doi: 10.1117/1.3526368.</mixed-citation><mixed-citation xml:lang="en">Parthasarathy AB, Weber EL, Richards LM, et al. Laser speckle contrast imaging of cerebral bloodflow in humans during neurosurgery: A pilot clinical study. Journal of Biomedical Optics 2010;15(6). doi: 10.1117/1.3526368.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Potapova EV, Dremin VV, Zherebtsov EA, et al. Evaluation of microcirculatory disturbances in patients with rheumatic diseases by the method of diffuse reflectance spectroscopy. Human Physiology 2017;43(2):222-228. doi: 10.1134/S036211971702013X.</mixed-citation><mixed-citation xml:lang="en">Potapova EV, Dremin VV, Zherebtsov EA, et al. Evaluation of microcirculatory disturbances in patients with rheumatic diseases by the method of diffuse reflectance spectroscopy. Human Physiology 2017;43(2):222-228. doi: 10.1134/S036211971702013X.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Rusakov IG, Sokolov VV, Bulgakova NN, et al. Fluorescent diagnostic methods and superficial cancer of the urinary bladder: current status. Urologiia (Moscow, Russia : 1999) 2008(3):67-68, 70-72.</mixed-citation><mixed-citation xml:lang="en">Rusakov IG, Sokolov VV, Bulgakova NN, et al. Fluorescent diagnostic methods and superficial cancer of the urinary bladder: current status. Urologiia (Moscow, Russia : 1999) 2008(3):67-68, 70-72.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Saito H, Ishikawa T, Tanabe J, et al. Bedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease. Scientific Reports 2018;8(1). doi: 10.1038/s41598-018-19668-5.</mixed-citation><mixed-citation xml:lang="en">Saito H, Ishikawa T, Tanabe J, et al. Bedside assessment of regional cerebral perfusion using near-infrared spectroscopy and indocyanine green in patients with atherosclerotic occlusive disease. Scientific Reports 2018;8(1). doi: 10.1038/s41598-018-19668-5.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Salmin VV, Lazarenko VI, Salmina AB, et al. Diagnosis of corneal pathology by laser fluorescence spectroscopy. Journal of Applied Spectroscopy 2012;79(4):626-631. doi: 10.1007/s10812-012-9649-4.</mixed-citation><mixed-citation xml:lang="en">Salmin VV, Lazarenko VI, Salmina AB, et al. Diagnosis of corneal pathology by laser fluorescence spectroscopy. Journal of Applied Spectroscopy 2012;79(4):626-631. doi: 10.1007/s10812-012-9649-4.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Shaffer EA. Epidemiology and risk factors for gallstone disease: Has the paradigm changed in the 21st century? Current Gastroenterology Reports 2005;7(2):132-140. doi: 10.1007/s11894-005-0051-8.</mixed-citation><mixed-citation xml:lang="en">Shaffer EA. Epidemiology and risk factors for gallstone disease: Has the paradigm changed in the 21st century? Current Gastroenterology Reports 2005;7(2):132-140. doi: 10.1007/s11894-005-0051-8.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Sherwinter DA. Identification of Anomolous Biliary Anatomy Using Near-Infrared Cholangiography. Journal of Gastrointestinal Surgery 2012;16(9):1814-1815. doi: 10.1007/s11605-012-1945-z.</mixed-citation><mixed-citation xml:lang="en">Sherwinter DA. Identification of Anomolous Biliary Anatomy Using Near-Infrared Cholangiography. Journal of Gastrointestinal Surgery 2012;16(9):1814-1815. doi: 10.1007/s11605-012-1945-z.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Shi H, Sun N, Mayevsky A, et al. Early identification of acute hypoxia based on brain NADH fluorescence and cerebral blood flow. Journal of Innovative Optical Health Sciences 2014;7(2). doi: 10.1142/S1793545814500333.</mixed-citation><mixed-citation xml:lang="en">Shi H, Sun N, Mayevsky A, et al. Early identification of acute hypoxia based on brain NADH fluorescence and cerebral blood flow. Journal of Innovative Optical Health Sciences 2014;7(2). doi: 10.1142/S1793545814500333.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Tsai FC, Huang YT, Chang LY, et al. Pyogenic liver abscess as endemic disease, Taiwan. Emerging Infectious Diseases 2008;14(10):1592-1600. doi: 10.3201/eid1410.071254.</mixed-citation><mixed-citation xml:lang="en">Tsai FC, Huang YT, Chang LY, et al. Pyogenic liver abscess as endemic disease, Taiwan. Emerging Infectious Diseases 2008;14(10):1592-1600. doi: 10.3201/eid1410.071254.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Tsai MT, Tsai TY, Shen SC, et al. Evaluation of laser-assisted trans-nail drug delivery with optical coherence tomography. Sensors (Switzerland) 2016;16(12). doi: 10.3390/s16122111.</mixed-citation><mixed-citation xml:lang="en">Tsai MT, Tsai TY, Shen SC, et al. Evaluation of laser-assisted trans-nail drug delivery with optical coherence tomography. Sensors (Switzerland) 2016;16(12). doi: 10.3390/s16122111.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Wang TD, Van Dam J. Optical biopsy: A new frontier in endoscopic detection and diagnosis. Clinical Gastroenterology and Hepatology 2004;2(9):744-753. doi: 10.1016/S1542-3565(04)00345-3.</mixed-citation><mixed-citation xml:lang="en">Wang TD, Van Dam J. Optical biopsy: A new frontier in endoscopic detection and diagnosis. Clinical Gastroenterology and Hepatology 2004;2(9):744-753. doi: 10.1016/S1542-3565(04)00345-3.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Wessels R, De Bruin DM, Faber DJ, et al. Optical biopsy of epithelial cancers by optical coherence tomography (OCT). Lasers in Medical Science 2014;29(3):1297-1305. doi: 10.1007/s10103-013-1291-8.</mixed-citation><mixed-citation xml:lang="en">Wessels R, De Bruin DM, Faber DJ, et al. Optical biopsy of epithelial cancers by optical coherence tomography (OCT). Lasers in Medical Science 2014;29(3):1297-1305. doi: 10.1007/s10103-013-1291-8.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Zarrinpar A, Dutson EP, Mobley C, et al. Intraoperative Laparoscopic Near-Infrared Fluorescence Cholangiography to Facilitate Anatomical Identification: When to Give Indocyanine Green and How Much. Surgical Innovation. 2016; 23(4):360-365. doi: 10.1177/1553350616637671.</mixed-citation><mixed-citation xml:lang="en">Zarrinpar A, Dutson EP, Mobley C, et al. Intraoperative Laparoscopic Near-Infrared Fluorescence Cholangiography to Facilitate Anatomical Identification: When to Give Indocyanine Green and How Much. Surgical Innovation. 2016; 23(4):360-365. doi: 10.1177/1553350616637671.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang L, Pleskow DK, Turzhitsky V, et al. Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy. Nature Biomedical Engineering. 2017;1(4). doi: 10.1038/s41551-017-0040.</mixed-citation><mixed-citation xml:lang="en">Zhang L, Pleskow DK, Turzhitsky V, et al. Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy. Nature Biomedical Engineering. 2017;1(4). doi: 10.1038/s41551-017-0040.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Zherebtsov E, Dremin V, Zharkikh E, et al. Fibre-optic probe for fluorescence diagnostics with blood influence compensation. 2018. Proceedings Volume 10493, Dynamics and Fluctuations in Biomedical Photonics XV; 104931L. doi: 10.1117/12.2290431.</mixed-citation><mixed-citation xml:lang="en">Zherebtsov E, Dremin V, Zharkikh E, et al. Fibre-optic probe for fluorescence diagnostics with blood influence compensation. 2018. Proceedings Volume 10493, Dynamics and Fluctuations in Biomedical Photonics XV; 104931L. doi: 10.1117/12.2290431.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Zherebtsov EA, Kandurova KY, Seryogina ES, et al. The influence of local pressure on evaluation parameters of skin blood perfusion and fluorescence. 2017. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 10336,1033608. doi: 10.1117/12.2267957.</mixed-citation><mixed-citation xml:lang="en">Zherebtsov EA, Kandurova KY, Seryogina ES, et al. The influence of local pressure on evaluation parameters of skin blood perfusion and fluorescence. 2017. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 10336,1033608. doi: 10.1117/12.2267957.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
