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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microcirculation</journal-id><journal-title-group><journal-title xml:lang="ru">Регионарное кровообращение и микроциркуляция</journal-title><trans-title-group xml:lang="en"><trans-title>Regional blood circulation and microcirculation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-6655</issn><issn pub-type="epub">2712-9756</issn><publisher><publisher-name>Academician I.P. Pavlov First St. Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1682-6655-2019-18-1-77-85</article-id><article-id custom-type="elpub" pub-id-type="custom">microcirculation-296</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ (КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ)</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES (CLINICAL INVESTIGATIONS)</subject></subj-group></article-categories><title-group><article-title>Применение оптической когерентной томографии в визуализации сосудистой стенки коронарных артерий до и после стентирования</article-title><trans-title-group xml:lang="en"><trans-title>The use of optical coherence tomography imaging of the vascular wall of the coronary arteries before and after stenting</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трусов</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Trusov</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Трусов Иван Сергеевич – врач-кардиолог приемного отделения № 1 НИИ хирургии и неотложной медицины, ассистент кафедры терапии факультетской с курсом эндокринологиии, кардиологии и функциональной диагностики с клиникой</p><p>197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8</p><p> </p></bio><bio xml:lang="en"><p>Trusov Ivan S. – Cardiologist of the admission department № 1 of the Research Institute of Surgery and Emergency Medicine, Assistant of the Faculty Therapy Department with a course of endocrinology, cardiology and functional diagnostics with a clinic</p><p>197022, Saint-Petersburg, L’va Tolstogo street, 6-8 </p></bio><email xlink:type="simple">trus-medic@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нифонтов</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Nifontov</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нифонтов Евгений Михайлович – доктор медицинских наук, профессор кафедры терапии факультетской с курсом эндокринологиии, кардиологии и функциональной диагностики с клиникой, заведующий лабораторией неотложной кардиологии НИИ сердечно-сосудистых заболеваний</p><p>197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8</p><p> </p></bio><bio xml:lang="en"><p>Nifontov Evgeniy M. – Ph. D., Professor of the Faculty Therapy Department with a course of endocrinology, cardiology and functional diagnostics with a clinic, Head of the Emergency Cardiology Laboratory of the Research Institute of Cardiovascular Diseases</p><p>197022, Saint-Petersburg, L’va Tolstogo street, 6-8 </p></bio><email xlink:type="simple">nifontovem@1spbgmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бирюков</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Biryukov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бирюков Алексей Владимирович – кандидат медицинских наук, зав. отделением рентгенохирургических методов диагностики и лечения № 1 НИИ хирургии и неотложной медицины</p><p>197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8</p><p> </p></bio><bio xml:lang="en"><p>Biryukov Alexey V. – PhD, Head of the Department of X-ray Surgical Diagnostic and Treatment Methods No. 1 of the Research Institute of Surgery and Emergency Medicine</p><p>197022, Saint-Petersburg, L’va Tolstogo street, 6-8 </p></bio><email xlink:type="simple">m.l.m@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванченко</surname><given-names>Р. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanchenko</surname><given-names>R. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванченко Роман Дмитриевич – врач по рентгеноэндоваскулярным диагностике и лечению отделения рентгенхирургических методов диагностики и лечения № 1 НИИ хирургии и неотложной медицины</p><p>197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8</p><p> </p></bio><bio xml:lang="en"><p>Ivanchenko Roman D. – doctor of the department of x-ray diagnostic methods and treatment No. 1 of the Research Institute of Surgery and Emergency Medicine</p><p>197022, Saint-Petersburg, L’va Tolstogo street, 6-8 </p></bio><email xlink:type="simple">r.d.ivanchenko@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мелиоранская</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Melioranskaia</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мелиоранская Екатерина Игоревна – врач-кардиолог кардиологического отделения № 1 НИИ сердечно-сосудистых заболеваний клиники НКИЦ</p><p>197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8</p><p> </p></bio><bio xml:lang="en"><p>Melioranskaia Ekaterina I. – cardiologist of the cardiology department № 1 of the Institute of Cardiovascular Diseases</p><p>197022, Saint-Petersburg, L’va Tolstogo street, 6-8 </p></bio><email xlink:type="simple">e.melioranskaia@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Добровольский</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dobrovolskiy</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Добровольский Вадим Валерьевич – студент 6 курса лечебного факультета</p><p>197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8</p></bio><bio xml:lang="en"><p>Dobrovolskiy Vadim V. – 6th year student of medical faculty</p><p>197022, Saint-Petersburg, L’va Tolstogo street, 6-8 </p></bio><email xlink:type="simple">Dashh46@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гуляева</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gulyaeva</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гуляева Татьяна Валерьевна – студентка 6 курса лечебного факультета</p><p>197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8</p></bio><bio xml:lang="en"><p>Gulyaeva Tatyana V. – 6th year student of medical faculty</p><p>197022, Saint-Petersburg, L’va Tolstogo street, 6-8 </p></bio><email xlink:type="simple">gulyaeva_1994@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивлева</surname><given-names>О. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivleva</surname><given-names>O. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ивлева Ольга Эдуардовна – студентка 6 курса лечебного факультета</p><p>197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8</p></bio><bio xml:lang="en"><p>Ivleva Olga E. – 6th year student of medical faculty</p><p>197022, Saint-Petersburg, L’va Tolstogo street, 6-8 </p></bio><email xlink:type="simple">olgaivl@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Academician I. P. Pavlov First St. Petersburg State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>03</day><month>05</month><year>2019</year></pub-date><volume>18</volume><issue>1</issue><fpage>77</fpage><lpage>85</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Трусов И.С., Нифонтов Е.М., Бирюков А.В., Иванченко Р.Д., Мелиоранская Е.И., Добровольский В.В., Гуляева Т.В., Ивлева О.Э., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Трусов И.С., Нифонтов Е.М., Бирюков А.В., Иванченко Р.Д., Мелиоранская Е.И., Добровольский В.В., Гуляева Т.В., Ивлева О.Э.</copyright-holder><copyright-holder xml:lang="en">Trusov I.S., Nifontov E.M., Biryukov A.V., Ivanchenko R.D., Melioranskaia E.I., Dobrovolskiy V.V., Gulyaeva T.V., Ivleva O.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.microcirc.ru/jour/article/view/296">https://www.microcirc.ru/jour/article/view/296</self-uri><abstract><sec><title>Введение</title><p>Введение. Оптическая когерентная томография (ОКТ) – метод внутрисосудистой визуализации, который позволяет оценить структуру сосудистой стенки, а также контролировать процесс установки и заживления стента.</p><p>Цель – выявить факторы, влияющие на неоинтимальное сосудистое заживление после имплантации стентов с лекарственным покрытием.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. 35 пациентам с острым коронарным синдромом без элевации ST были установлены эверолимус­содержащие стенты с постоянным и биодеградируемым полимером. Через 6 месяцев пациентам выполнена контрольная коронарография вместе с ОКТ, проанализировано состояние неоинтимы ранее имплантированных стентов. Оценивались клинические, анамнестические и лабораторные показатели.</p></sec><sec><title>Результаты</title><p>Результаты. Проанализировано 28 750 страт стентов, рассчитан показатель индекса заживления. Индекс заживления зависел от возраста пациента (r=0,60710; p=0,0003), наличия в анамнезе сахарного диабета (р=0,0477), текущего инфаркта миокарда (р=0,0183) и степени поражения коронарных артерий (р=0,0355). Индекс заживления достоверно ниже у пациентов со значением Syntax score &lt;22 (р=0,004).</p></sec><sec><title>Выводы</title><p>Выводы. Основными факторами, ухудшающими неоинтимальное заживление, являются возраст, наличие диабета, характер поражения коронарного русла, что может повлиять на длительность антиагрегантной терапии.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Optical coherence tomography (OCT) is an intravascular imaging method that allows to evaluate the structure of the vascular wall, as well as to monitor the process of stent installation and healing.</p><p>The aim of this work was to identify factors affecting neointimal vascular healing after implantation of drug­eluting stents.</p></sec><sec><title>Material and methods</title><p>Material and methods. In 35 patients with acute coronary syndrome without ST elevation, everolimus­eluted stents with permanent and biodegradable polymer were installed. After 6 months patients underwent control coronary angiography with OCT, the state of neointima of previously implanted stents was analyzed. Clinical, anamnestic and laboratory parameters were evaluated.</p></sec><sec><title>Results</title><p>Results. 28750 struts of stents were analyzed and the healing score was calculated. The healing score depended on the patient’s age (r=0.60710, p=0.0003), a history of diabetes mellitus (p=0.0477), current myocardial infarction (p=0.0183), and the degree of coronary artery disease (p=0.0355). The healing score was signifcantly lower in patients with a Syntax score &lt;22 (p=0.004).</p></sec><sec><title>Conclusion</title><p>Conclusion. The results of the research showed that main factors that impair neointimal healing are age, the presence of diabetes, the characteristics of the lesion of the coronary arteries; they may affect the duration of dual antiplatelet therapy.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>коронарные артерии</kwd><kwd>стенты</kwd><kwd>оптическая когерентная томография</kwd><kwd>индекс заживления</kwd><kwd>потеря просвета</kwd><kwd>Syntax</kwd></kwd-group><kwd-group xml:lang="en"><kwd>coronary arteries</kwd><kwd>stents</kwd><kwd>optical coherence tomography</kwd><kwd>healing score</kwd><kwd>lumen loss</kwd><kwd>Syntax score</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nichols M, Townsend N, Scarborough P, Rayner M. Cardiovascular disease in Europe 2014: epidemiological update. European Heart Journal [Internet]. 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