microcirculationРегионарное кровообращение и микроциркуляцияRegional blood circulation and microcirculation1682-66552712-9756Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1682-6655-2011-10-1-46-52microcirculation-527Research ArticleСтатьиТолщина комплекса интима-медиа общих сонных артерий и Q192R-полиморфизм гена параоксоназы-1 у больных абдоминальным ожирением.БеляеваО. Д.colgabel@pisem.netБерезинаА. В.colgabel@pisem.netЧубенкоЕ. А.colgabel@pisem.netКароноваТ. Л.colgabel@pisem.netВолковаА. Р.colgabel@pisem.netБаженоваЕ. А.colgabel@pisem.netКозловаС. Н.colgabel@pisem.netЛарионоваВ. И.colgabel@pisem.netАнаньеваН. И.colgabel@pisem.netВайшалиМ. .colgabel@pisem.netБарановаЕ. И.colgabel@pisem.netБерковичО. А.colgabel@pisem.netСанкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова; Федеральный центр сердца, крови и эндокринологии им. В. А. АлмазоваRussian FederationСанкт-Петербургский государственный медицинский университет им. акад. И. П. ПавловаRussian FederationСанкт-Петербургская государственная педиатрическая медицинская академияRussian FederationНаучно-исследовательский психо-неврологический институт им. В. М. БехтереваRussian Federation2011300320111014652Copyright © Беляева О.Д., Березина А.В., Чубенко Е.А., Каронова Т.Л., Волкова А.Р., Баженова Е.А., Козлова С.Н., Ларионова В.И., Ананьева Н.И., Вайшали М..., Баранова Е.И., Беркович О.А., 20112011Беляева О.Д., Березина А.В., Чубенко Е.А., Каронова Т.Л., Волкова А.Р., Баженова Е.А., Козлова С.Н., Ларионова В.И., Ананьева Н.И., Вайшали М..., Баранова Е.И., Беркович О.А.Беляева О.Д., Березина А.В., Чубенко Е.А., Каронова Т.Л., Волкова А.Р., Баженова Е.А., Козлова С.Н., Ларионова В.И., Ананьева Н.И., Вайшали М..., Баранова Е.И., Беркович О.А.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.microcirc.ru/jour/article/view/527

Обследованы 480 больных абдоминальным ожирением в возрасте от 30 до 55 лет. Гипертриглицеридемия была выявлена у 182 больных (38,0 %), снижение уровня холестерина липопротеинов высокой плотности - у 158 больных (33,1 %). Дуплексное сканирование сонных артерий выявило утолщение комплекса интима-медиа (133 больных (61,6 %)) и наличие атеросклеротических бляшек у 86 больных (39,8 %), что свидетельствует о раннем развитии атеросклероза у больных абдоминальным ожирением. Показатели липидного спектра крови при Q192R-полиморфном варианте гена параоксоназы-1 у этих больных не различаются, однако носительство R192R-генотипа этого гена ассоциировано с увеличением толщины комплекса интима-медиа общих сонных артерий.

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