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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microcirculation</journal-id><journal-title-group><journal-title xml:lang="ru">Регионарное кровообращение и микроциркуляция</journal-title><trans-title-group xml:lang="en"><trans-title>Regional blood circulation and microcirculation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-6655</issn><issn pub-type="epub">2712-9756</issn><publisher><publisher-name>Academician I.P. Pavlov First St. Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1682-6655-2011-10-2-19-23</article-id><article-id custom-type="elpub" pub-id-type="custom">microcirculation-538</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Изменение показателей перфузии миокарда после интракоронарного введения аутологичных мононуклеарных клеток костного мозга больным ишемической болезнью сердца. Пятилетнее наблюдение.</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Седов</surname><given-names>В. М.</given-names></name></name-alternatives><email xlink:type="simple">vmsedov@spmu.rssi.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бурнос</surname><given-names>С. Н.</given-names></name></name-alternatives><email xlink:type="simple">vmsedov@spmu.rssi.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Немков</surname><given-names>А. С.</given-names></name></name-alternatives><email xlink:type="simple">vmsedov@spmu.rssi.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белый</surname><given-names>С. А.</given-names></name></name-alternatives><email xlink:type="simple">vmsedov@spmu.rssi.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нестерук</surname><given-names>Ю. А.</given-names></name></name-alternatives><email xlink:type="simple">vmsedov@spmu.rssi.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юдина</surname><given-names>О. В.</given-names></name></name-alternatives><email xlink:type="simple">vmsedov@spmu.rssi.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>СПбГМУ им. акад. И. П. Павлова</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>30</day><month>06</month><year>2011</year></pub-date><volume>10</volume><issue>2</issue><fpage>19</fpage><lpage>23</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Седов В.М., Бурнос С.Н., Немков А.С., Белый С.А., Нестерук Ю.А., Юдина О.В., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Седов В.М., Бурнос С.Н., Немков А.С., Белый С.А., Нестерук Ю.А., Юдина О.В.</copyright-holder><copyright-holder xml:lang="en">Седов В.М., Бурнос С.Н., Немков А.С., Белый С.А., Нестерук Ю.А., Юдина О.В.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.microcirc.ru/jour/article/view/538">https://www.microcirc.ru/jour/article/view/538</self-uri><abstract><p>Начиная с 2003 года, в исследовании с интракоронарным введением аутологичных мононуклеарных клеток костного мозга приняли участие 119 неоперабельных больных с ишемической болезнью сердца. У 41 из них посредством однофотонной эмиссионной компьютерной томографии оценивалась перфузия миокарда. Полученные данные свидетельствуют об улучшении перфузии миокарда. В основной массе пациентов такая тенденция сохраняется до 3 лет - медиана доли миокарда с дефицитом перфузии 40 % и более уменьшалась на 1,1-5,1 %, а в отдельных случаях улучшение перфузии сохраняется до пяти лет. Интракоронарное введение мононуклеарных клеток костного мозга является безопасным и эффективным методом инвазивной терапии у больных ишемической болезнью сердца, которым по ряду причин противопоказано оперативное лечение, а консервативная терапия не дает желаемого эффекта. Полученные данные свидетельствуют о стойком улучшении перфузии миокарда в некоторых случаях до 5 лет.</p></abstract><kwd-group xml:lang="ru"><kwd>перфузия миокарда</kwd><kwd>мононуклеарные клетки костного мозга</kwd><kwd>ишемическая болезнь сердца</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Assmus, B. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI) / B. Assmus [et al.] // Circulation. - 2002. - Vol. 106. - № 24. - P. 3009-3017.</mixed-citation><mixed-citation xml:lang="en">Assmus, B. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI) / B. 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