microcirculationРегионарное кровообращение и микроциркуляцияRegional blood circulation and microcirculation1682-66552712-9756Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1682-6655-2020-19-1-35-46microcirculation-716Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИ (КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ)ORIGINAL ARTICLES (CLINICAL INVESTIGATIONS)Состояние микроциркуляции и биохимические маркеры эндотелиальной дисфункции после медикаментозного лечения и хирургической коррекции кровотока у больных с атеросклерозом сосудов нижних конечностейMicrocirculation and biochemical markers of endothelial dysfunction after medical and surgical treatment in patients with peripheral arterial diseaseПаршаковА. А.ParshakovA. A.

Паршаков Алексей Андреевич – канд. мед. наук, ассистент, кафедра общей хирургии №1

614000, г. Пермь, ул. Петропавловская, д. 26

Parshakov Aleksey A. – MD

26 Petropavlovskaya str., Perm, 614000

parshakov-aleksey@mail.ruЗубареваН. А.ZubarevaN. A.

Зубарева Надежда Анатольевна – д-р мед. наук, профессор, кафедра общей хирургии №1

614000, г. Пермь, ул. Петропавловская, д. 26

Zubareva Nadezhda A. – MD, PhD

26 Petropavlovskaya str., Perm, 614000

nzubareva07@mail.ruМизеваИ. А.MizevaI. A.

Мизева Ирина Андреевна – канд. физ.-мат. наук, научный сотрудник

614013, г. Пермь, ул. Академика Королёва, д. 1

Mizeva Irina A. – PhD, researcher

1 Academician Korolev str., Perm, 614013

mizeva@icmm.ruПодтаевС. Ю.PodtaevS. Yu.

Подтаев Сергей Юрьевич – канд. физ.-мат. наук, директор по НИОКР

614013, г. Пермь, ул. Академика Королёва, д. 1614031, г. Пермь, ул. Докучаева, д. 31а 

Podtaev Sergey Yu. – PhD, R&D Director

1 Academician Korolev str., Perm, 61401331a Dokuchaeva str., Perm, 614031 

spt802@gmail.comФедеральное государственное бюджетное образовательное учреждение высшего образования «Пермский государственный медицинский университет имени академика Е. А. Вагнера» Министерства здравоохранения Российской ФедерацииРоссияE. A. Vagner Perm State Medical UniversityRussian FederationФедеральное государственное бюджетное учреждение науки «Институт механики сплошных сред» Уральского отделения Российской академии наукРоссияInstitute of Continuous Media Mechanics of the Ural Branch of Russian Academy of ScienceRussian FederationФедеральное государственное бюджетное учреждение науки «Институт механики сплошных сред» Уральского отделения Российской академии наук; Научно-производственное предприятие «Системы контроля»РоссияInstitute of Continuous Media Mechanics of the Ural Branch of Russian Academy of Science; Control Systems Ltd.Russian Federation2020060420201913546Copyright © Паршаков А.А., Зубарева Н.А., Мизева И.А., Подтаев С.Ю., 20202020Паршаков А.А., Зубарева Н.А., Мизева И.А., Подтаев С.Ю.Parshakov A.A., Zubareva N.A., Mizeva I.A., Podtaev S.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.microcirc.ru/jour/article/view/716хроническая артериальная недостаточностьреваскулязизациятермометрия высокого разрешенияэндотелингомоцистеинфункция эндотелияperipheral arterial diseaserevascularizationhigh resolution thermometryendothelinhomocysteineendothelium funсtionРабота была поддержана РФФИ в рамках проекта 17-44-590755.The study was supported by RFBR (Project 17-44-590755).ReferencesGoodall R, Salciccioli JD, Davies AH, Marshall D, Shalhoub J. Trends in peripheral arterial disease incidence and mortality in EU15+ countries 1990-2017. Eur J Prev Cardiol. 2020;Feb 3:2047487319899626. Doi: 10.1177/2047487319899626.Goodall R, Salciccioli JD, Davies AH, Marshall D, Shalhoub J. Trends in peripheral arterial disease incidence and mortality in EU15+ countries 1990-2017. Eur J Prev Cardiol. 2020;Feb 3:2047487319899626. Doi: 10.1177/2047487319899626.Pérez-Cremades D, Cheng HS, Feinberg MW. Noncoding RNAs in Critical Limb Ischemia. Arterioscler Thromb Vasc Biol. 2020;Jan 2: Mar;40(3):523–533. Epub 2020 Jan 2. Doi: 10.1161/ATVBAHA.119.312860.Pérez-Cremades D, Cheng HS, Feinberg MW. Noncoding RNAs in Critical Limb Ischemia. Arterioscler Thromb Vasc Biol. 2020;Jan 2: Mar;40(3):523–533. Epub 2020 Jan 2. Doi: 10.1161/ATVBAHA.119.312860.Хронические облитерирующие заболевания артерий нижних конечностей – диагностика и тактика лечения / В. Н. Оболенский, Д. В. Яншин, Г. А. Исаев, А. А. Плотников // Рос. мед. журн. – 2010. – Т. 17. – С. 1049.Obolenskii VN, Yanshin DV, Isaev GA, Plotnokov AA. Chronic obliterating diseases of the arteries of the lower extremities diagnosis and treatment tactics. Russian medical journal. 2010;17:1049. (In Russ.).Rossi M, Capri A. Skin microcirculation in peripheral arterial obliterative disease. Biomed and pharm. 2004;58(6): 427–431. Doi: 10.1016/j.biopha.2004.08.004.Rossi M, Capri A. Skin microcirculation in peripheral arterial obliterative disease. Biomed and pharm. 2004;58(6): 427–431. Doi: 10.1016/j.biopha.2004.08.004.Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FGR. Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). J. Vasc. Surg. 2007;26(2):81–157. Doi: 10.1016/j.jvs.2006.12.037.Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FGR. Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). J. Vasc. Surg. 2007;26(2):81–157. Doi: 10.1016/j.jvs.2006.12.037.Ruggiero D, Paolillo S, Ratta GD et al. Endothelial function as a marker of pre-clinical atherosclerosis: assessment techniques and clinical implications. Italian Monaldi Arch Chest Dis. 2013;80:106–110. Doi: 10.4081/monaldi.2013.71.Ruggiero D, Paolillo S, Ratta GD et al. Endothelial function as a marker of pre-clinical atherosclerosis: assessment techniques and clinical implications. Italian Monaldi Arch Chest Dis. 2013;80:106–110. Doi: 10.4081/monaldi.2013.71.Pushpakumar S, Kundu S, Sen U. Endothelial dysfunction: the link between homocysteine and hydrogen sulfide. Curr Med Chem. 2014;21:3662–3672. Doi: 10.2174/0929867321666140706142335.Pushpakumar S, Kundu S, Sen U. Endothelial dysfunction: the link between homocysteine and hydrogen sulfide. Curr Med Chem. 2014;21:3662–3672. Doi: 10.2174/0929867321666140706142335.Komai H, Higami Y,Tanaka H et al. Impaired flow-mediated endothelium-dependent and endothelium-independent vasodilation of the brachial artery in patients with atherosclerotic peripheral vascular disease. Angiology. 2008;59:5256. Doi: 10.1177/0003319707303442.Komai H, Higami Y,Tanaka H et al. Impaired flow-mediated endothelium-dependent and endothelium-independent vasodilation of the brachial artery in patients with atherosclerotic peripheral vascular disease. Angiology. 2008;59:5256. Doi: 10.1177/0003319707303442.Kotschy D, Kotschy M, Socha P et al. Selected endothelial hemostatic markers in patients with peripheral arterial disease after endovascular revascularization and restenosis formation. Polish PostepyHig Med Dosw. 2015;69:905–912. Doi: 10.5604/17322693.1164409.Kotschy D, Kotschy M, Socha P et al. Selected endothelial hemostatic markers in patients with peripheral arterial disease after endovascular revascularization and restenosis formation. Polish PostepyHig Med Dosw. 2015;69:905–912. Doi: 10.5604/17322693.1164409.Nezami N, Sepehrvand N, Mirchi M et al. Serum and tissue endothelin-1 are independent from intima-media thickness of peripheral arteries in patients with chronic kidney disease. Vascular. 2015;23:382–390. Doi: 10.1177/1708538114551195.Nezami N, Sepehrvand N, Mirchi M et al. Serum and tissue endothelin-1 are independent from intima-media thickness of peripheral arteries in patients with chronic kidney disease. Vascular. 2015;23:382–390. Doi: 10.1177/1708538114551195.Park SJ, Kim H, Park JK. Comparison of Clinical and Hematologic Factors Associated with Stenosis and Aneurysm Development in Patients with Atherosclerotic Arterial Disease. Ann Vasc Surg. 2019 Oct;60:165–170. Doi: 10.1016/j.avsg.2019.03.003.Park SJ, Kim H, Park JK. Comparison of Clinical and Hematologic Factors Associated with Stenosis and Aneurysm Development in Patients with Atherosclerotic Arterial Disease. Ann Vasc Surg. 2019 Oct;60:165–170. Doi: 10.1016/j.avsg.2019.03.003.Васина Л. В., Петрищев Н. Н., Власов Т. Д. Эндотелиальная дисфункция и ее основные маркеры // Регионар. кровообращение и микроциркуляция. – 2017. – Т. 16, № 1. С. 4–15. Doi: 10.24884/1682-6655-2017-16-1-4-15.Vasina LV, Petrishchev NN, Vlasov TD. Markers of endothelial dysfunction. Regional blood circulation and microcirculation. 2017;16(1):4–15. (In Russ.). Doi: 10.24884/1682-6655-2017-16-1-4-15.Sreckovic B, Sreckovic VD, Soldatovic I, Colak E, Sumarac-Dumanovic M, Janeski H, Janeski N, Gacic J, Mrdovic I. Homocysteine is a marker for metabolic syndrome and atherosclerosis. Diabetes MetabSyndr. 2017;11(3):179–182. Doi: 10.1016/j.dsx.2016.08.026.Sreckovic B, Sreckovic VD, Soldatovic I, Colak E, Sumarac-Dumanovic M, Janeski H, Janeski N, Gacic J, Mrdovic I. Homocysteine is a marker for metabolic syndrome and atherosclerosis. Diabetes MetabSyndr. 2017;11(3):179–182. Doi: 10.1016/j.dsx.2016.08.026.Patel S, Celermajer DS. Assessment of vascular disease using arterial flow mediated dilatation. Pharmacol Rep. 2006; 58 Suppl:3–7.Patel S, Celermajer DS. Assessment of vascular disease using arterial flow mediated dilatation. Pharmacol Rep. 2006; 58 Suppl:3–7.Frolow M, Drozdz A, Kowalewska A et al. Comprehensive assessment of vascular health in patients; towards endothelium-guided therapy. Pharmacol Rep. 2015;67:786792. Doi: 10.1016/j.pharep.2015.05.010.Frolow M, Drozdz A, Kowalewska A et al. Comprehensive assessment of vascular health in patients; towards endothelium-guided therapy. Pharmacol Rep. 2015;67:786792. Doi: 10.1016/j.pharep.2015.05.010.Mizeva I, Dumler A, Muraviev N. Changes in the Spectral Characteristics of Plethysmographic Waveforms Due to PAOD. Proceedings of the International Joint Conference on Biomedical Engineering Systems and Technologies. 2014; 4:149–154. Doi: 10.5220/0004747301490154.Mizeva I, Dumler A, Muraviev N. Changes in the Spectral Characteristics of Plethysmographic Waveforms Due to PAOD. Proceedings of the International Joint Conference on Biomedical Engineering Systems and Technologies. 2014; 4:149–154. Doi: 10.5220/0004747301490154.Stefanovska A, Bracic M, Kvernmo HD. Wavelet analysis of oscillations in the peripheral blood circulation measured by laser Doppler technique. IEEE Trans Biomed Eng. 1999; 46:12301239. Doi: 10.1109/10.790500.Stefanovska A, Bracic M, Kvernmo HD. Wavelet analysis of oscillations in the peripheral blood circulation measured by laser Doppler technique. IEEE Trans Biomed Eng. 1999; 46:12301239. Doi: 10.1109/10.790500.Лазерная допплеровская флоуметрия микроциркуляции крови: рук. для врачей / под ред. А. И. Крупаткина, В. В. Сидорова. – М.: Медицина, 2005. – 256 с.Lazernaya dopplerovskaya floumetriya mikrotsirkulyatsii krovi. Rukovodstvo dlya vrachei. Ed. by Krupatkin AI, Sidorov VV. Moscow, Meditsina, 2005:256. (In Russ.).Tankanag AV. Applications of the Adaptive Wavelet Transform for Analyzing Peripheral Blood Flow Oscillations in the Human Skin. Medical Physics. Ed. M. Balcerzyk. NY, Nova Science Publishers, 2013:85–104.Tankanag AV. Applications of the Adaptive Wavelet Transform for Analyzing Peripheral Blood Flow Oscillations in the Human Skin. Medical Physics. Ed. M. Balcerzyk. NY, Nova Science Publishers, 2013:85–104.Frick P, Mizeva I, Podtaev S. Skin temperature variations as a tracer of microvessel tone. Biomed Signal Proces. 2015;21:1–7. Doi: 10.1016/j.bspc.2015.04.014.Frick P, Mizeva I, Podtaev S. Skin temperature variations as a tracer of microvessel tone. Biomed Signal Proces. 2015;21:1–7. Doi: 10.1016/j.bspc.2015.04.014.Sagaidachnyi A, Fomin A, Usanov D, Skripal F. Realtime technique for conversion of skin temperature into skin blood flow: human skin as a low-pass filter for thermal waves. Computer Methods in Biomechanics and Biomedical Engineering. 2019;22:1009–1019. Doi: 10.1080/10255842.2019.1615058.Sagaidachnyi A, Fomin A, Usanov D, Skripal F. Realtime technique for conversion of skin temperature into skin blood flow: human skin as a low-pass filter for thermal waves. Computer Methods in Biomechanics and Biomedical Engineering. 2019;22:1009–1019. Doi: 10.1080/10255842.2019.1615058.Podtaev S, Morozov M, Frick P. Wavelet-based correlations of skin temperature and blood flow oscillations. Cardiovasc Eng. 2008;8:185189.Podtaev S, Morozov M, Frick P. Wavelet-based correlations of skin temperature and blood flow oscillations. Cardiovasc Eng. 2008;8:185189.Shiogai Y, Stefanovska A, McClintock PVE. Nonlinear dynamics of cardiovascular ageing. Phys Rep. 2010;488:51110.Shiogai Y, Stefanovska A, McClintock PVE. Nonlinear dynamics of cardiovascular ageing. Phys Rep. 2010;488:51110.Kuliga KZ, McDonald EF, Gush R et al. Dynamics of microvascular blood flow and oxygenation measured simultaneously in human skin. Microcirculation. 2014;21:562573.Kuliga KZ, McDonald EF, Gush R et al. Dynamics of microvascular blood flow and oxygenation measured simultaneously in human skin. Microcirculation. 2014;21:562573.Stephens DP, Charkoudian N, Benevento JM et al. The influence of topical capsaicin on the local thermal control of skin blood flow in humans. Am J Physiol Regul Integr Comp Physiol. 2001;281:894901.Stephens DP, Charkoudian N, Benevento JM et al. The influence of topical capsaicin on the local thermal control of skin blood flow in humans. Am J Physiol Regul Integr Comp Physiol. 2001;281:894901.Johnson JM, Kellogg DL. Local thermal control of the human cutaneous circulation. J Appl Physiol. 2010;109: 12291238.Johnson JM, Kellogg DL. Local thermal control of the human cutaneous circulation. J Appl Physiol. 2010;109: 12291238.Podtaev S, Stepanov R, Smirnova E et al. Waveletanalysis of skin temperature oscillations during local heating for revealing endothelial dysfunction. Microvasc Res. 2015; 97:109114.Podtaev S, Stepanov R, Smirnova E et al. Waveletanalysis of skin temperature oscillations during local heating for revealing endothelial dysfunction. Microvasc Res. 2015; 97:109114.Johnson JM, Kellogg DL. Local thermal control of the human cutaneous circulation. J Appl Physiol. 2010; 109:12291238.Johnson JM, Kellogg DL. Local thermal control of the human cutaneous circulation. J Appl Physiol. 2010; 109:12291238.Parshakov A, Zubareva N, Podtaev S, Frick P. Detection of endothelial dysfunction using skin temperature oscillations analysis during local heating in patients with peripheral arterial disease. Microcirculation. 2016;23(6):406–415. Doi: 10.1111/micc.12283.Parshakov A, Zubareva N, Podtaev S, Frick P. Detection of endothelial dysfunction using skin temperature oscillations analysis during local heating in patients with peripheral arterial disease. Microcirculation. 2016;23(6):406–415. Doi: 10.1111/micc.12283.Agarwal S, Sud K, Shishehbor MH. Nationwide Trends of Hospital Admission and Outcomes Among Critical Limb Ischemia Patients During 2003-2011. J Am Coll Cardiol. 2016; 67;1901–1913.Agarwal S, Sud K, Shishehbor MH. Nationwide Trends of Hospital Admission and Outcomes Among Critical Limb Ischemia Patients During 2003-2011. J Am Coll Cardiol. 2016; 67;1901–1913.Bath J, Avgerinos E. A pooled analysis of common femoral and profundafemoris endovascular interventions. Vascular. 2016;24:404–413.Bath J, Avgerinos E. A pooled analysis of common femoral and profundafemoris endovascular interventions. Vascular. 2016;24:404–413.Smirnova E, Podtaev S, Mizeva I, Loran E. Assessment of endothelial dysfunction in patients with impaired glucose tolerance during a cold pressor test. Diabvasc dis res. 2013;10(6):489–497.Smirnova E, Podtaev S, Mizeva I, Loran E. Assessment of endothelial dysfunction in patients with impaired glucose tolerance during a cold pressor test. Diabvasc dis res. 2013;10(6):489–497.Jan YK, Struck BD, Foreman RD, Robinson C. Wavelet analysis of sacral skin blood flow oscillations to assess soft tissue viability in older adults. Microvasc res. 2009;78(2): 162–168.Jan YK, Struck BD, Foreman RD, Robinson C. Wavelet analysis of sacral skin blood flow oscillations to assess soft tissue viability in older adults. Microvasc res. 2009;78(2): 162–168.Kvandal P, Landsverk SA, Bernjak A, Stefanovska A, Kvernmo HD, Kirkeboen KA. Low- frequency oscillations of the laser Doppler perfusion signal in human skin. Microvasc Res. 2006;72:120127. Doi: 10.1016/j.mvr.2006.05.006.Kvandal P, Landsverk SA, Bernjak A, Stefanovska A, Kvernmo HD, Kirkeboen KA. Low- frequency oscillations of the laser Doppler perfusion signal in human skin. Microvasc Res. 2006;72:120127. Doi: 10.1016/j.mvr.2006.05.006.Parshakov A, Zubareva N, Podtaev S, Frick P. Local Heating Test for Detection of Microcirculation Abnormalities in Patients with Diabetes-Related Foot Complications. Advances in Skin & Wound Care. 2017;30(4):158–166. Doi: 10.1097/01.ASW.0000508635.06240.c9.Parshakov A, Zubareva N, Podtaev S, Frick P. Local Heating Test for Detection of Microcirculation Abnormalities in Patients with Diabetes-Related Foot Complications. Advances in Skin & Wound Care. 2017;30(4):158–166. Doi: 10.1097/01.ASW.0000508635.06240.c9.Taylor LM, De Frang RD, Harris Jr EJ, Porter JM. The association of elevated plasma homocysteine with progression of symptomatic peripheral arterial disease. J Vasc Surg. 1991;13:128–136. Doi: 10.1067/mva.1991.24913.Taylor LM, De Frang RD, Harris Jr EJ, Porter JM. The association of elevated plasma homocysteine with progression of symptomatic peripheral arterial disease. J Vasc Surg. 1991;13:128–136. Doi: 10.1067/mva.1991.24913.Pawlaczyk KA, Gabriel M, Urbanek T et al. Changes in flow-mediated dilatation in patients with femoropopliteal occlusion receiving conservative and invasive treatment. Kardiol Pol. 2016;74(8):772778. Doi: 10.5603/KP.a2016.0027.Pawlaczyk KA, Gabriel M, Urbanek T et al. Changes in flow-mediated dilatation in patients with femoropopliteal occlusion receiving conservative and invasive treatment. Kardiol Pol. 2016;74(8):772778. Doi: 10.5603/KP.a2016.0027.Komai H, Higami Y,Tanaka H et al. Impaired flow-mediated endothelium-dependent and endothelium-independent vasodilation of the brachial artery in patients with atherosclerotic peripheral vascular disease. Angiology. 2008;59:5256. Doi: 10.1177/0003319707303442.Komai H, Higami Y,Tanaka H et al. Impaired flow-mediated endothelium-dependent and endothelium-independent vasodilation of the brachial artery in patients with atherosclerotic peripheral vascular disease. Angiology. 2008;59:5256. Doi: 10.1177/0003319707303442.Hiatt WR, Armstrong EJ, Larson CJ et al. Pathogenesis of the limb manifestations and exercise limitations in peripheral artery disease. Circ Res. 2015;116:1527–1539. Doi: 10.1161/CIRCRESAHA.116.303566.Hiatt WR, Armstrong EJ, Larson CJ et al. Pathogenesis of the limb manifestations and exercise limitations in peripheral artery disease. Circ Res. 2015;116:1527–1539. Doi: 10.1161/CIRCRESAHA.116.303566.Yao HQ, Wang FJ, Kang Z. Effects of endovascular interventions on vWF and Fb Levels in type 2 diabetic patients with peripheral artery disease. Ann Vasc Surg. 2016;33:159–166. Doi: 10.1016/j.avsg.2015.11.018.Yao HQ, Wang FJ, Kang Z. Effects of endovascular interventions on vWF and Fb Levels in type 2 diabetic patients with peripheral artery disease. Ann Vasc Surg. 2016;33:159–166. Doi: 10.1016/j.avsg.2015.11.018.Kotschy D, Kotschy M, Socha P et al. Selected endothelial hemostatic markers in patients with peripheral arterial disease after endovascular revascularization and restenosis formation. Polish Postepy Hig Med Dosw. 2015;69:905–912. Doi: 10.5604/17322693.1164409.Kotschy D, Kotschy M, Socha P et al. Selected endothelial hemostatic markers in patients with peripheral arterial disease after endovascular revascularization and restenosis formation. Polish Postepy Hig Med Dosw. 2015;69:905–912. Doi: 10.5604/17322693.1164409.

The authors declare that there are no conflicts of interest present.