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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">microcirculation</journal-id><journal-title-group><journal-title xml:lang="ru">Регионарное кровообращение и микроциркуляция</journal-title><trans-title-group xml:lang="en"><trans-title>Regional blood circulation and microcirculation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-6655</issn><issn pub-type="epub">2712-9756</issn><publisher><publisher-name>Academician I.P. Pavlov First St. Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1682-6655-2020-19-1-60-66</article-id><article-id custom-type="elpub" pub-id-type="custom">microcirculation-720</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ (ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ)</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES (EXPERIMENTAL INVESTIGATIONS)</subject></subj-group></article-categories><title-group><article-title>Взаимосвязь эндотелиальных факторов вазорегуляции и состояния антиоксидантной системы с клиническими проявлениями ревматоидного артрита</article-title><trans-title-group xml:lang="en"><trans-title>The relationship of endothelial vasoregulation factors and the state of the antioxidant system with manifestations of rheumatoid arthritis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Александрова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Alexandrova</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Александрова Людмила Александровна – канд. биол. наук, старший научный сотрудник отдела биохимии НОИ биомедицины</p><p>197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8</p></bio><bio xml:lang="en"><p>Alexandrova Ludmila A. – Cand. of Sci. (Biol.), senior researcher at the laboratory of biochemical monitoring of the Scientific and Educational Institute of Biomedicine</p><p>6-8 L’va Tolstogo str., Saint Petersburg, 197022</p></bio><email xlink:type="simple">laa2004@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Субботина</surname><given-names>Т. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Subbotina</surname><given-names>T. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Cубботина Татьяна Федоровна – д-р мед. наук, профессор, руководитель лаборатории биохимического мониторинга отдела биохимии НОИ биомедицины</p><p>197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8</p></bio><bio xml:lang="en"><p>Subbotina Tatjana F. – Dr. of Sci. (Med.), Professor, head of the laboratory of biochemical monitoring at the Department of biochemistry of Scientific and Educational Institute of Biomedicine</p><p>6-8 L’va Tolstogo str., Saint Petersburg, 197022</p></bio><email xlink:type="simple">subbotina2002@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филиппова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Filippova</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Филиппова Нина Александровна – канд. мед. наук, доцент кафедры терапии госпитальной с курсом аллергологии и иммунологии им. акад. М. В.Черноруцкого с клиникой</p><p>197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8</p></bio><bio xml:lang="en"><p>Filippova Nina A. – Cand. of Sci. (Med.), Docent, Associate Professor at the Department of hospital therapy with a course of allergology and immunology im. akad. M. V. Chernorutsky with the clinic</p><p>6-8 L’va Tolstogo str., Saint Petersburg, 197022</p></bio><email xlink:type="simple">nafil@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жлоба</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhloba</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жлоба Александр Анатольевич – д-р мед. наук, профессор, руководитель отдела биохимии НОИ биомедицины</p><p>197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8</p></bio><bio xml:lang="en"><p>Zhloba Alexandr A. – Dr. of Sci. (Med.), Professor, head of the Department of biochemistry at Scientific and Educational Institute of Biomedicine</p><p>6-8 L’va Tolstogo str., Saint Petersburg, 197022</p></bio><email xlink:type="simple">zhloba@mail.spbnit.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трофимов</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Trofimov</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Трофимов Василий Иванович – профессор, зав. кафедрой терапии госпитальной с курсом аллергологии и иммунологии им. акад. М. В.Черноруцкого с клиникой</p><p>197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8</p></bio><bio xml:lang="en"><p>Trofimov Vasilij I. – Dr. of Sci. (Med.), Professor, head of the Department of hospital therapy with a course of allergology and immunology im. akad. M. V. Chernorutsky with the clinic</p><p>6-8 L’va Tolstogo str., Saint Petersburg, 197022</p></bio><email xlink:type="simple">trofvi@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pavlov University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>06</day><month>04</month><year>2020</year></pub-date><volume>19</volume><issue>1</issue><fpage>60</fpage><lpage>66</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Александрова Л.А., Субботина Т.Ф., Филиппова Н.А., Жлоба А.А., Трофимов В.И., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Александрова Л.А., Субботина Т.Ф., Филиппова Н.А., Жлоба А.А., Трофимов В.И.</copyright-holder><copyright-holder xml:lang="en">Alexandrova L.A., Subbotina T.F., Filippova N.A., Zhloba A.A., Trofimov V.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.microcirc.ru/jour/article/view/720">https://www.microcirc.ru/jour/article/view/720</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>супероксиддисмутаза</kwd><kwd>глутатионпероксидаза</kwd><kwd>глутатионредуктаза</kwd><kwd>глутатион восстановленный (GSH)</kwd><kwd>эндотелиальная дисфункция</kwd><kwd>эндотелин-1</kwd><kwd>фактор роста сосудов эндотелия (VEGF-A)</kwd></kwd-group><kwd-group xml:lang="en"><kwd>superoxide dismutase (SOD)</kwd><kwd>glutathione peroxidase (GPO)</kwd><kwd>glutathione reductase (GR)</kwd><kwd>reduced glutathione (GSH)</kwd><kwd>endothelial dysfunction</kwd><kwd>endothelin-1</kwd><kwd>vascular growth factor endothelium (VEGF-A)</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Петрищев Н. 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