microcirculationРегионарное кровообращение и микроциркуляцияRegional blood circulation and microcirculation1682-66552712-9756Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1682-6655-2020-19-3-57-63microcirculation-849Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИ (ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ)ORIGINAL ARTICLES (EXPERIMENTAL INVESTIGATIONS)Опиоидэргическая регуляция сократительной активности лимфатических сосудовOpioidergic regulation of contractile activity of lymphatic vesselsНечайкинаО. В.NechaykinaO. V.

Нечайкина Ольга Валерьевна – старший научный сотрудник лаборатории молекулярной токсикологии и экспериментальной терапии

188663, Ленинградская область, пос. Кузьмоловский, ст. Капитолово, корп. №93

Nechaykina Olga V. – Senior Researcher of the Laboratory of Molecular Toxicology and Experimental Therapy

188663, Leningradskaya oblast’, pos. Kuz’molovskij, st. Kapitolovo, korp. №93

olga2278@mail.ruПетуновС. Г.PetunovS. G.

Петунов Сергей Гервасиевич – канд. мед. наук, доцент, заведующий научно-организационным отделом

188663, Ленинградская область, пос. Кузьмоловский, ст. Капитолово, корп. №93

Petunov Sergei G. – Candidate of Medical Sciences, Associate Professor, Head of the Scientific and Organizational Department

188663, Leningradskaya oblast’, pos. Kuz’molovskij, st. Kapitolovo, korp. №93

sergey-petunov@mail.ruЛаптевД. С.LaptevD. S.

Лаптев Денис Сергеевич – канд. биол. наук, зав. лабораторией экстремальной физиологии

188663, Ленинградская область, пос. Кузьмоловский, ст. Капитолово, корп. №93

Laptev Denis S. – Candidate of Biological Sciences, Head of the Laboratory of Extreme Physiology

188663, Leningradskaya oblast’, pos. Kuz’molovskij, st. Kapitolovo, korp. №93

lapden@mail.ruФедеральное государственное унитарное предприятие «Научно-исследовательский институт гигиены, профпатологии и экологии человека» Федерального медико-биологического агентства РоссииРоссияResearch Institute of Hygiene, Occupational Pathology and Human Ecology of the Federal Medical and Biological AgencyRussian Federation2020071020201935763Copyright © Нечайкина О.В., Петунов С.Г., Лаптев Д.С., 20202020Нечайкина О.В., Петунов С.Г., Лаптев Д.С.Nechaykina O.V., Petunov S.G., Laptev D.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.microcirc.ru/jour/article/view/849лимфатические сосудыопиоидные рецепторыопиоидные пептидыlymphatic vesselsopioid receptorsopioid peptidesReferencesAnanthan S. Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics. AAPS J. 2006;8(1):118–125. Doi: 10.1208/aapsj080114.Ananthan S. Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics. AAPS J. 2006;8(1):118–125. Doi: 10.1208/aapsj080114.Курзанов А. Н. Лиганды опиоидных рецепторов в ракурсе клинической гастроэнтерологии // Соврем. проблемы науки и образования. – 2011. – Т. 6. – С. 34–45.Kurzanov AN. Ligands of opioid receptors in the framework of clinical gastroenterology. Modern problems of science and education. 2011;6:34–45. (In Russ.).Pattinson KT. Opioids and the control of respiration. Br J Anaesth. 2008;100:747–758. Doi: 10.1093/bja/aen094.Pattinson KT. Opioids and the control of respiration. Br J Anaesth. 2008;100:747–758. Doi: 10.1093/bja/aen094.Morin-Surun MP, Boudinot E, Dubois C et al. Respiratory function in adult mice lacking the muopioid receptor: role of delta-receptors. Eur Neurobiol. 2001;13(9):1703–1710.Morin-Surun MP, Boudinot E, Dubois C et al. Respiratory function in adult mice lacking the muopioid receptor: role of delta-receptors. Eur Neurobiol. 2001;13(9):1703–1710.Saraiva J, Oliveira SM, Rocha-Sousa A, Leite-Moreira A. Opioid Receptors and Preconditioning of the Heart. Rev Port Cardiol. 2004;23(10):1317–1333.Saraiva J, Oliveira SM, Rocha-Sousa A, Leite-Moreira A. Opioid Receptors and Preconditioning of the Heart. Rev Port Cardiol. 2004;23(10):1317–1333.Pepe S, van den Brink OW, Lakatta EG, Xiao RP. Crosstalk of opioid peptide receptor and beta-adrenergic receptor signalling in the heart. Cardiovasc Res. 2004;63(3):414–422. Doi: 10.1016/j.cardiores.2004.04.022.Pepe S, van den Brink OW, Lakatta EG, Xiao RP. Crosstalk of opioid peptide receptor and beta-adrenergic receptor signalling in the heart. Cardiovasc Res. 2004;63(3):414–422. Doi: 10.1016/j.cardiores.2004.04.022.Sheng WS, Hu S, Gekker G, Zhu S, Peterson PK, Chao CC. Immunomodulatory role of opioids in the central nervous system. Arch Immunol Ther Exp (Warsz). 1997;45(5–6): 359–366.Sheng WS, Hu S, Gekker G, Zhu S, Peterson PK, Chao CC. Immunomodulatory role of opioids in the central nervous system. Arch Immunol Ther Exp (Warsz). 1997;45(5–6): 359–366.Mansour A, Fox CA, Akil H, Watson SJ. Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci. 1995;18(1):22–29. Doi: 10.1016/0166-2236(95)93946-u.Mansour A, Fox CA, Akil H, Watson SJ. Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci. 1995;18(1):22–29. Doi: 10.1016/0166-2236(95)93946-u.Beadles-Bohling AS, Wiren KM. Alteration of kappaopioid receptor system expression in distinct brain regions of a genetic model of enhanced ethanol withdrawal severity. Brain Res. 2005;1046(1–2):77–89. Doi: 10.1016/j.brainres.2005.03.043.Beadles-Bohling AS, Wiren KM. Alteration of kappaopioid receptor system expression in distinct brain regions of a genetic model of enhanced ethanol withdrawal severity. Brain Res. 2005;1046(1–2):77–89. Doi: 10.1016/j.brainres.2005.03.043.Headrick JP, See Hoe LE, Du Toit EF, Peart JN. Opioid receptors and cardioprotection - ‘opioidergic conditioning’ of the heart. Br J Pharmacol. 2015;172(8):2026–2050. Doi: 10.1111/bph.13042.Headrick JP, See Hoe LE, Du Toit EF, Peart JN. Opioid receptors and cardioprotection - ‘opioidergic conditioning’ of the heart. Br J Pharmacol. 2015;172(8):2026–2050. Doi: 10.1111/bph.13042.Barron BA. Opioid peptides and the heart. Cardiovasc Res. 1999;43:13–16. Doi: 10.1016/s0008-6363(99)00112-1.Barron BA. Opioid peptides and the heart. Cardiovasc Res. 1999;43:13–16. Doi: 10.1016/s0008-6363(99)00112-1.Wood JD, Galligan JJ. Function of opioids in the enteric nervous system. Neurogastroenterol Motil. 2004;16(S2):17–28. Doi: 10.1111/j.1743-3150.2004.00554.x.Wood JD, Galligan JJ. Function of opioids in the enteric nervous system. Neurogastroenterol Motil. 2004;16(S2):17–28. Doi: 10.1111/j.1743-3150.2004.00554.x.Cechova K, Hlouskova M, Javorkova E et al. Upregulation of μ-, δ- and κ-opioid receptors in concanavalin A-stimulated rat spleen lymphocytes. J Neuroimmunol. 2018;321:12–23. Doi: 10.1016/j.jneuroim.2018.05.008.Cechova K, Hlouskova M, Javorkova E et al. Upregulation of μ-, δ- and κ-opioid receptors in concanavalin A-stimulated rat spleen lymphocytes. J Neuroimmunol. 2018;321:12–23. Doi: 10.1016/j.jneuroim.2018.05.008.Ласукова Т. В., Маслов Л. Н., Горбунов А. С. О роли опиоидной системы миокарда в реализации кардиопротекторного эффекта посткондиционирования // Рос. физиол. журн. им. Сеченова. – 2014. – Т. 100, № 12. – С. 1391-1398.Lasukova TV, Maslov LN, Gorbunov AS. On the role of opioid system of myocardium in the implementation of the cardioprotective effect of postconditioning. Russian Journal of Physiology. 2014;100(12):1391–1398. (In Russ.).Маслов Л. Н., Лишманов Ю. Б., Гросс Г. Д. и др. Активация опиатных рецепторов изменяет устойчивость сердца к ишемическим и реперфузионным повреждениям // Вестн. аритмологии. – 2002. – Т. 28. – С. 67–78.Maslov LN, Lishmanov YuB, Gross GD, Shul’ts DED, Stefano GB. Aktivatsiya opiatnykh retseptorov izmenyaet ustoichivost’ serdtsa k ishemicheskim i reperfuzionnym povrezhdeniyam. Vestnik aritmologii. 2002;28:67–78. (In Russ.).Stefano GB, Hartman A, Bilfinger TV et al. Presence of the mu3 opiate receptor in endothelial cells. Coupling to nitric oxide production and vasodilation. J. Biol. Chem. 1995; 270(51):30290–30293. Doi: 10.1074/jbc.270.51.30290.Stefano GB, Hartman A, Bilfinger TV et al. Presence of the mu3 opiate receptor in endothelial cells. Coupling to nitric oxide production and vasodilation. J. Biol. Chem. 1995; 270(51):30290–30293. Doi: 10.1074/jbc.270.51.30290.Wilbert-Lampen U, Trapp A, Barth S et al. Effects of beta-endorphin on endothelial/monocytic endothelin-1 and nitric oxide release mediated by mu1-opioid receptors: a potential link between stress and endothelial dysfunction? Endothelium. 2007;14(2):65–71. Doi: 10.1080/10623320701346585.Wilbert-Lampen U, Trapp A, Barth S et al. Effects of beta-endorphin on endothelial/monocytic endothelin-1 and nitric oxide release mediated by mu1-opioid receptors: a potential link between stress and endothelial dysfunction? Endothelium. 2007;14(2):65–71. Doi: 10.1080/10623320701346585.Saeed RW, Stefano GB, Murga JD, Short TW, Qi F, Bilfinger TV, Magazine HI. Expression of functional delta opioid receptors in vascular smooth muscle. International Journal of Molecular Medicine. 2000;6(6):673–677. Doi: 10.3892/ijmm.6.6.673.Saeed RW, Stefano GB, Murga JD, Short TW, Qi F, Bilfinger TV, Magazine HI. Expression of functional delta opioid receptors in vascular smooth muscle. International Journal of Molecular Medicine. 2000;6(6):673–677. Doi: 10.3892/ijmm.6.6.673.Брук Т. М., Лифке М. В. Динамика β-эндорфина в крови спортсменов различной квалификации в условиях нагрузки умеренной интенсивности на фоне низкоинтенсивного лазерного воздействия // Курский науч.практ. вестн. «Человек и его здоровье». – 2009. – Т. 2. С. 5–10.Brook TM, Lifke MV. Dynamics of beta-endorphin in the blood of athletes of various qualifications in the conditions of mild load exposed by low intensive laser. Kursk Scientific and Practical Bulletin “Man and His Health”. 2009;2:5–10. (In Russ.).Ozarda IY, Ozyurt G, Kilicturgay S, Uncu G, Ulus IH. The decline in serum choline concentration in humans during and after surgery is associated with the elevation of cortisol, adrenocorticotropic hormone, prolactin and beta-endorphin concentrations. Neurosci Lett. 2002 May 10;324(1):41-44. Doi: 10.1016/s0304-3940(02)00171-4.Ozarda IY, Ozyurt G, Kilicturgay S, Uncu G, Ulus IH. The decline in serum choline concentration in humans during and after surgery is associated with the elevation of cortisol, adrenocorticotropic hormone, prolactin and beta-endorphin concentrations. Neurosci Lett. 2002 May 10;324(1):41-44. Doi: 10.1016/s0304-3940(02)00171-4.Гейн С. В., Баева Т. А. Эндогенные опиоидные пептиды в регуляции функций клеток врожденного иммунитета // Обзор. Биохимия. – 2011. – Т. 76, № 3. – С. 379–390. Doi: 10.1134/s0006297911030035.Gein SV, Baeva TA. Endogenous opioid peptides in regulation of innate immunity cell functions. Biochemistry. 2011;76(4):309–319. (In Russ.). Doi: 10.1134/s0006297911030035.Kido K, Shindo Y, Toda S, Masaki E. Expression of β-endorphin in peripheral tissues after systemic administration of lipopolysaccharide as a model of endotoxic shock in mice. Ann Endocrinol (Paris). 2019;80(2):117–121. Doi: 10.1016/j.ando.2018.06.001.Kido K, Shindo Y, Toda S, Masaki E. Expression of β-endorphin in peripheral tissues after systemic administration of lipopolysaccharide as a model of endotoxic shock in mice. Ann Endocrinol (Paris). 2019;80(2):117–121. Doi: 10.1016/j.ando.2018.06.001.Skarphedinsson JO, Thoren P. Endorphin mechanisms are responsible for the beneficial effects of opioid antagonists on cerebral function during relative cerebral ischaemia in rats. Acta Physiologica Scandinavica. 1988;132(3):281–288. Doi: 10.1111/j.1748-1716.1988.tb08331.x.Skarphedinsson JO, Thoren P. Endorphin mechanisms are responsible for the beneficial effects of opioid antagonists on cerebral function during relative cerebral ischaemia in rats. Acta Physiologica Scandinavica. 1988;132(3):281–288. Doi: 10.1111/j.1748-1716.1988.tb08331.x.Маслов Л. Н., Лишманов Ю. Б., Гросс Г. Д., Стефано Д. Феномен повышения устойчивости сердца к аритмогенному действию ишемии и реперфузии при активации периферических опиатных рецепторов // Вестн. аритмологии. – 2002. – Т. 26. – С. 77–90.Maslov LN, Lishmanov YuB, Gross GD, Stefano D. Fenomen povysheniya ustoichivosti serdtsa k aritmogennomu deistviyu ishemii i reperfuzii pri aktivatsii perifericheskikh opiatnykh retseptorov. Vestnik aritmologii. 2002;26:77–90. (In Russ.).Kho HG, Kloppenborg PW, van Egmond J. Effects of acupuncture and transcutaneous stimulation analgesia on plasma hormone levels during and after major abdominal surgery. Eur J Anaesthesiol. 1993;10(3):197–208.Kho HG, Kloppenborg PW, van Egmond J. Effects of acupuncture and transcutaneous stimulation analgesia on plasma hormone levels during and after major abdominal surgery. Eur J Anaesthesiol. 1993;10(3):197–208.Нечайкина О. В., Петунов С. Г., Радилов А. С. Влияние β-эндорфина на сократительную активность изолированных лимфатических сосудов крысы // Регионар. кровообращение и микроциркуляция. – 2013. – Т. 12, № 3. С. 64–70.Nechaykina OV, Petunov SG, Radilov AS. Effect of β-endorphin on contractile activity of isolated rat lymph vessels. Regional Blood Circulation and Microcirculation. 2013;12(3):64–70. (In Russ.).Нечайкина О. В., Лаптев Д. С., Петунов С. Г., Радилов А. С. Влияние β-эндорфина на функциональные параметры изолированного сердца и лимфатических сосудов белой крысы // Вестн. Северо-Запад. гос. мед. унта им. И. И. Мечникова. – 2019. – Т. 11, № 2. – С. 43–48. Doi: 10.17816/mechnikov201911243-48.Nechaykina OV, Laptev DS, Petunov SG, Radilov AS. The effect of β-endorphin on the functional parameters of the isolated heart and lymphatic vessels of the white rat. Vestnik SeveroZapadnogo gosudarstvennogo meditsinskogo universiteta im. I. I. Mechnikova. 2019;11(2):43–48. (In Russ.). Doi: 10.17816/mechnikov201911243-48.Zadina JE, Hackler L, Ge LJ, Kastin AJ. A potent and selective endogenous agonist for the m-opiate receptor. Nature (Lond). 1997;386:499–502. Doi: 10.1038/386499a0.Zadina JE, Hackler L, Ge LJ, Kastin AJ. A potent and selective endogenous agonist for the m-opiate receptor. Nature (Lond). 1997;386:499–502. Doi: 10.1038/386499a0.Hackler L, Zadina JЕ, Ge LJ, Kastin AJ. Isolation of Relatively Large Amounts of Endomorphin-1 and Endomorphin-2 From Human Brain Cortex. Peptides. 1997;18(10):1635–1639. Doi: 10.1016/s0196-9781(97)00259-3.Hackler L, Zadina JЕ, Ge LJ, Kastin AJ. Isolation of Relatively Large Amounts of Endomorphin-1 and Endomorphin-2 From Human Brain Cortex. Peptides. 1997;18(10):1635–1639. Doi: 10.1016/s0196-9781(97)00259-3.Kosson P, Bonney I, Carr DB, Lipkowski AW. Endomorphins interact with tachykinin receptors. Peptides. 2005; 26:1667–1669. Doi: 10.1016/j.peptides.2005.02.006.Kosson P, Bonney I, Carr DB, Lipkowski AW. Endomorphins interact with tachykinin receptors. Peptides. 2005; 26:1667–1669. Doi: 10.1016/j.peptides.2005.02.006.Chakraborty S, Nepiyushchikh Z, Davis MJ, Zawieja DC, Muthuchamy M. Substance P activates both contractile and inflammatory pathways in lymphatics through the neurokinin receptors NK1R and NK3R. Microcirculation. 2011;8(1): 24–35. Doi: 10.1111/j.1549-8719.2010.00064.x.Chakraborty S, Nepiyushchikh Z, Davis MJ, Zawieja DC, Muthuchamy M. Substance P activates both contractile and inflammatory pathways in lymphatics through the neurokinin receptors NK1R and NK3R. Microcirculation. 2011;8(1): 24–35. Doi: 10.1111/j.1549-8719.2010.00064.x.Champion HC, Zadina JE, Kastin AJ, Kadowitz PJ. The endogenous mu-opioid agonists, endomorphin 1 and 2, have vasodilator activity in the hindquarters vascular bed of the rat. Life Sci. 1997;61(26):409–415.Champion HC, Zadina JE, Kastin AJ, Kadowitz PJ. The endogenous mu-opioid agonists, endomorphin 1 and 2, have vasodilator activity in the hindquarters vascular bed of the rat. Life Sci. 1997;61(26):409–415.Champion HC, Kadowitz PJ. D-[Ala2]endomorphin 2 and endomorphin 2 have nitric oxide-dependent vasodilator activity in rats. Am J Physiol. 1998;274(5):1690–H1697. Doi: 10.1152/ajpheart.1998.274.5.H1690.Champion HC, Kadowitz PJ. D-[Ala2]endomorphin 2 and endomorphin 2 have nitric oxide-dependent vasodilator activity in rats. Am J Physiol. 1998;274(5):1690–H1697. Doi: 10.1152/ajpheart.1998.274.5.H1690.Parra L, Pérez-Vizcaíno F, Alsasua A, Martín MI, Tamargo J. mu- and delta-opioid receptor-mediated contractile effects on rat aortic vascular smooth muscle. Eur J Pharmacol. 1995;277(1):99–105. Doi: 10.1016/0014-2999(95)00067-u.Parra L, Pérez-Vizcaíno F, Alsasua A, Martín MI, Tamargo J. mu- and delta-opioid receptor-mediated contractile effects on rat aortic vascular smooth muscle. Eur J Pharmacol. 1995;277(1):99–105. Doi: 10.1016/0014-2999(95)00067-u.Oldenburg O, Cohen MV, Yellon DM, Downey JM. Mitochondrial K (ATP) channels: role in cardioprotection. Cardiovasc. Res. 2002;55(3):429–437. Doi: 10.1016/s00086363(02)00439-x.Oldenburg O, Cohen MV, Yellon DM, Downey JM. Mitochondrial K (ATP) channels: role in cardioprotection. Cardiovasc. Res. 2002;55(3):429–437. Doi: 10.1016/s00086363(02)00439-x.Alt A, Mansour A, Akil H, Medzihradsky F, Traynor J, Woods J. Stimulation of guanosine-5´-O-(3-[35S] thio) triphosphate binding by endogenous opioids acting at a cloned m receptor. J Pharmacol Exp Ther. 1998;286:282–288.Alt A, Mansour A, Akil H, Medzihradsky F, Traynor J, Woods J. Stimulation of guanosine-5´-O-(3-[35S] thio) triphosphate binding by endogenous opioids acting at a cloned m receptor. J Pharmacol Exp Ther. 1998;286:282–288.Нечайкина О. В., Петунов С. Г. Влияние эндоморфина-1 на сократительную активность брыжеечных лимфатических сосудов крысы // Бюл. эксперим. биологии и медицины. – 2019. – Т. 168, № 7. – С. 63–67. Doi:10.1007/s10517-019-04645-3.Nechaykina OV, Petunov SG. Effect of endomorphine-1 on the contractile activity of rat mesenteric lymphatic vessels. Bulletin of Experimental Biology and Medicine. 2019;168(7):63–67. (In Russ.). Doi:10.1007/s10517-019-04645-3.Horvath G. Endomorphin-1 and endomorphin-2: pharmacology of the selective endogenous mu-opioid receptor agonists. Pharmacol Ther. 2000;88:437–463. Doi: 10.1016/s0163-7258(00)00100-5.Horvath G. Endomorphin-1 and endomorphin-2: pharmacology of the selective endogenous mu-opioid receptor agonists. Pharmacol Ther. 2000;88:437–463. Doi: 10.1016/s0163-7258(00)00100-5.

The authors declare that there are no conflicts of interest present.