References

microcirculation

Регионарное кровообращение и микроциркуляция

Regional blood circulation and microcirculation

1682-66552712-9756

Academician I.P. Pavlov First St. Petersburg State Medical University

10.24884/1682-6655-2012-11-3-4-11

microcirculation-889

Research Article

ОБЗОРЫ

REVIEWS

P2Y1-рецепторы и их влияние на процессы агрегации тромбоцитов

P2Y1-receptors and it influence on platelet aggregation

Спасов

А. А.

Spasov

A. A.

aspasov@mail.ru

Яковлев

Д. С.

Yakovlev

D. S.

noemail@neicon.ru

Букатина

Т. М.

Bucatina

T. M.

noemail@neicon.ru

Волгоградский государственный медицинский университетРоссияVolgograd State Medical UniversityRussian Federation

2012

30092012

113411

2012

Спасов А.А., Яковлев Д.С., Букатина Т.М.

Spasov A.A., Yakovlev D.S., Bucatina T.M.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.microcirc.ru/jour/article/view/889

Большое внимание уделяется исследованию активности P2Y1-рецепторов тромбоцитов и P2Y1-опосредованного механизма агрегации как возможной перспективной мишени для создания новой группы антитромбоцитарных препаратов. Это объясняется тем, что активация данного рецептора на мембране тромбоцитов приводит к инициации стадии контактной активации клеток - обратимого этапа агрегации. Доказанная ключевая роль P2Y1-рецептора в регуляции процесса агрегации, повышении резистентности к тромбообразованию, в снижении времени кровотечения свидетельствует о целесообразности и научном интересе поиска и изучения антагонистов данных рецепторов как потенциальных антитромбоцитарных препаратов с принципиально новым механизмом действия - угнетение P2Y1-опосредованной обратимой стадии агрегации тромбоцитов. В данном обзоре описаны молекулярная структура P2Y1-рецептора, механизмы взаимодействия со вторичными сигнальными системами, механизм P2Y1-опосредованной активации и агрегации тромбоцитов. Изложена физиологическая роль данного рецептора. Представлена характеристика наиболее изученных к настоящему времени антагонистов P2Y1-рецепторов как новых потенциальных антиагрегантов.

Much attention to date is giving to the activity of P2Y1-receptors of platelets and P2Y1-mediated mechanism of aggregation as a potential promising target for the creation of new antiplatelet drugs. This is explained by the fact that activation of this receptor on the platelet membrane, resulting in the initiation stage of the contact activation of cells - reversible phase of aggregation. Proved the key role of P2Y1-receptors in the regulation of the aggregation process, in increasing resistance to thrombosis, in reducing bleeding time indicates the expediency and scientific interest in the search and study of antagonists of these receptors as potential antiplatelet drugs with a novel mechanism of action - inhibition of P2Y1-mediated reversible phase of platelet aggregation. This review describes the molecular structure of the P2Y1-receptor, mechanism of P2Y1-mediated platelet activation and aggregation, the mechanisms of interaction with secondary signaling systems. We describe the physiological role of this receptor. Submitted the characteristics of the most studied to date antagonists of P2Y1-receptor as potential new antiplatelet agents.

тромбоцитактивация тромбоцитовагрегацияР2-рецепторы тромбоцитовP2Y1-рецепторP2Y1-антагонистыplateletplatelet activationaggregationP2-receptors of plateletsP2Y1-receptorP2Y1-antagonists

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The authors declare that there are no conflicts of interest present.