Angio- and Neuroprotective Effect of Remote Ischemic Preconditioning in Treatment with Focused Ultrasound under Magnetic Resonance Imaging Guidance
N. R. Mukhamadeeva,
O. V. Kachemaeva,
I. V. Buzaev,
R. M. Galimova,
I. A. Lakman,
Z. R. Nabieva,
G. M. Sakhautdinova,
A. V. Samorodov,
N. Sh. Zagidullin https://doi.org/10.24884/1682-6655-2026-25-1-45-51
Abstract
Introduction. Remote ischemic preconditioning (RIPC) is a promising intervention for protecting organs and tissues from damage.
The aim of this study was to evaluate the diagnostic efficacy of angioneuroprotective biomarkers in patients with extrapyramidal movement disorders undergoing magnetic resonance-guided focused ultrasound (MRgFUS) thermocoagulation.
Materials and Methods. 42 patients were enrolled in a prospective, randomized, blinded study with an active control (sham RIPC). Prior to the procedure, patients were randomized into either the RIPC group (cuff pressure set at systolic blood pressure + 50 mm Hg, n=21) or the sham RIPC group (cuff pressure set at diastolic blood pressure, n=21). The protocol in both groups consisted of three 5-minute cycles of the cuff inflation (preconditioning or its imitation) each followed by a 5-minute rest intervals. Levels of biomarkers (TRIM72, S100B, ubiquitin, Lp-PLA2, endothelin-1) were measured in blood serum before and 1 hour after MRgFUS procedure.
Results. Comparison of post-procedural biomarker levels revealed statistically significant differences: the S100B levels were higher in the sham RIPC group (1.34 ng/mL) compared to the RIPC group (0.44 ng/mL, p<0.001) and the ubiquitin level (5.8 ng/mL) were also higher than in the RIPC group (4.73 ng/mL) (p = 0.008). These findings indicate that prior RIPC is associated with suppression of biomarkers of neuroglial damage (S100B) and proteolytic stress (ubiquitin) released in response to thermocoagulation.
Conclusion. RIPC is associated with reduced levels of S100B and ubiquitin during MRgFUS thermocoagulation, demonstrating a cytoprotective effect by mitigating blood-brain barrier and neuronal damage.
Keywords
Supporting agencies: The work was carried out with the support of the Strategic Academic Leadership Program of Bashkir State Medical University (PRIORITY 2030)
About the Authors
N. R. Mukhamadeeva
Bashkir State Medical University; Intelligent Neurosurgery Clinic, International Medical Center V.S. Buzaev Memorial
Russian Federation
Russian Federation
Mukhamadeeva Nailya R. – PhD Student, Department of Propaedeutics of Internal Medicine, Bashkir State Medical University; Deputy Chief Physician for Medical Affairs, Cardiologist, Intelligent Neurosurgery Clinic, Buzaev International Medical Center.
3, Lenina str., Ufa, 450008; 7/4, Richarda Sorge str., Ufa, 450059
O. V. Kachemaeva
Bashkir State Medical University; Intelligent Neurosurgery Clinic, International Medical Center V.S. Buzaev Memorial
Russian Federation
Russian Federation
Kachemaeva Olga V. – Cand. Med. Sci., Associate Professor, Department of Neurology, Bashkir State Medical University; Neurologist, Fntelligent Neurosurgery Clinic, Buzaev Fnternational Medical Center.
3, Lenina str., Ufa, 450008; 7/4, Richarda Sorge str., Ufa, 450059
I. V. Buzaev
Bashkir State Medical University; Intelligent Neurosurgery Clinic, International Medical Center V.S. Buzaev Memorial
Russian Federation
Russian Federation
Buzaev Igor V. – Dr. Med. Sci., Professor, Department of Hospital Surgery, Bashkir State Medical University; Development Director, Cardiovascular Surgeon, Intelligent neurosurgery Clinic, Buzaev International Medical Center.
3, Lenina str., Ufa, 450008; 7/4, Richarda Sorge str., Ufa, 450059
R. M. Galimova
Bashkir State Medical University; Intelligent Neurosurgery Clinic, International Medical Center V.S. Buzaev Memorial
Russian Federation
Russian Federation
Galimova Rezida M. – Dr. Med. Sci., Associate Professor, Department of Neurosurgery and Medical Rehabilitation, Bashkir State Medical University; Neurosurgeon, Intelligent Neurosurgery Clinic, Buzaev International Medical Center.
3, Lenina str., Ufa, 450008; 7/4, Richarda Sorge str., Ufa, 450059
I. A. Lakman
Ufa University of Science and Technology
Russian Federation
Russian Federation
Lakman Irina A. – Cand. tech. Sci., Associate Professor, Head, Laboratory for Research of Social and Economic Problems of Regions.
32, Zaki Validi str., Ufa, 450076
Z. R. Nabieva
Ufa University of Science and Technology
Russian Federation
Russian Federation
Nabieva Zarina R. – Statistics Student.
32, Zaki Validi str., Ufa, 450076
G. M. Sakhautdinova
Bashkir State Medical University
Russian Federation
Russian Federation
Sakhautdinova Gulnar M. – Dr. Med. Sci., Professor, Department of Polyclinic Therapy.
3, Lenina str., Ufa, 450008
A. V. Samorodov
Bashkir State Medical University
Russian Federation
Russian Federation
Samorodov Alexander V. – Dr. Med. Sci., Associate Professor, Department of Pharmacology with Course of Clinical Pharmacology.
3, Lenina str., Ufa, 450008
N. Sh. Zagidullin
Bashkir State Medical University
Russian Federation
Russian Federation
Zagidullin Naufal Sh. – Dr. Med. Sci., Professor, Head, Department of Propaedeutics of Internal Medicine.
3, Lenina str., Ufa, 450008
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For citations:
Mukhamadeeva N.R., Kachemaeva O.V., Buzaev I.V., Galimova R.M., Lakman I.A., Nabieva Z.R., Sakhautdinova G.M., Samorodov A.V., Zagidullin N.Sh. Angio- and Neuroprotective Effect of Remote Ischemic Preconditioning in Treatment with Focused Ultrasound under Magnetic Resonance Imaging Guidance. Regional blood circulation and microcirculation. 2026;25(1):45-51. (In Russ.) https://doi.org/10.24884/1682-6655-2026-25-1-45-51
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