Intravital study of lymphatic drainage in lung cancer using indocyanine green
https://doi.org/10.24884/1682-6655-2020-19-3-19-24
Abstract
Introduction. The knowledge of lymph efflux and its features seems to be significant for diagnosis and treatment of cancer diseases. The purpose of this paper is exploration of the lymph efflux from lungs by infrared fluorescence in patients with lung cancer. Materials and methods. Indocyanine green (ICG) was injected peritumorally during the lung resection in 92 patients with non-small cells lung cancer (NSCLC). We managed to reliably visualize ICG fluorescence in at least 1 regional lymph node (LN) of the lung root or mediastinum in 70 patients (76%), they are included in the study. Results. The accumulation of ICG was detected in 63% of patients in the LN of the root and mediastinum, in 27% of cases - in the mediastinum only, in 10% of patients - in the hilar nodes only. There was no correlation between lesion of lymph node group and ICG injection in any lung lobe. Conclusions. The lymph efflux from different lung lobe is variable in patients with lung cancer. The lymph can run toward the nodes of both lung root and mediastinum.
About the Authors
A. L. Akopov
Pavlov University
Russian Federation
Russian Federation
Akopov Andrey L. – MD, professor, Head of the Department of thoracic surgery, Research Institute for Surgery and Emergency Medicine
6-8 L’va Tolstogo street, Saint Petersburg, 197022
G. V. Papayan
Pavlov University
Russian Federation
Russian Federation
Papayan Garry V. – PhD, Pavlov University, Almazov National Medical Research Centre
6-8 L’va Tolstogo street, Saint Petersburg, 197022
A. A. Ilin
Pavlov University
Russian Federation
Russian Federation
Ilin Andrey A. – Department of thoracic surgery, Research Institute for Surgery and Emergency Medicine
6-8 L’va Tolstogo street, Saint Petersburg, 197022
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Review
For citations:
Akopov A.L., Papayan G.V., Ilin A.A. Intravital study of lymphatic drainage in lung cancer using indocyanine green. Regional blood circulation and microcirculation. 2020;19(3):19-24. (In Russ.) https://doi.org/10.24884/1682-6655-2020-19-3-19-24
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