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Retinal vein occlusion after intake of sildenafil citrate

https://doi.org/10.24884/1682-6655-2017-16-2-70-74

Abstract

This article describes the case of a possible rare complication of sildenafil citrate use - central retinal vein occlusion. Sildenafil citrate influences on regional and systemic hemodynamics. The role of predisposing factors (arterial hypertension, hyperhomocysteinemia) and provoking factors (physical exercise, visiting sauna and a double dose of the potency regulator) is discussed. Combination of provoking factors including use of sildenafil citrate has resulted in acute decrease in regional perfusion pressure with the development of central retinal vein occlusion.

About the Authors

S. N. Tultseva
Academician I. P. Pavlov First St. Petersburg State Medical University
Russian Federation


A. I. Titarenko
Academician I. P. Pavlov First St. Petersburg State Medical University
Russian Federation


P. A. Nechiporenko
Academician I. P. Pavlov First St. Petersburg State Medical University
Russian Federation


References

1. Тульцева С. Н. Значение гипергомоцистеинемии в патогенезе ишемического тромбоза вен сетчатки // Офтальмолог. ведомости. 2008. № 1 (3). С. 31-40.

2. Тульцева С. Н., Астахов Ю. С., Титаренко А. И., Руховец А. Г. Суточный профиль артериального давления у пациентов с окклюзией вен сетчатки молодого и среднего возраста // Артериальная гипертензия. 2017.

3. Тульцева С. Н., Титаренко А. И., Руховец А. Г. Характеристика системной и регионарной гемодинамики при ишемической окклюзии вен сетчатки у лиц молодого и среднего возраста // Регионарное кровообращение и микроциркуляция. 2016. № 2(58). С. 24-31.

4. Azzouni F., Abu K. Are phosphodiesterase type 5 inhibitors associated with vision-threating adverse events? A critical analysis and review of the literature // J. Sex Med. 2011. № 8. Р. 2894-2903.

5. Browning D. J. Patchy ischemic retinal whitening inacute central retinal vein occlusion // Ophthalmology. 2002. № 109. Р. 2154-2159.

6. Chruscicki D. A., Sutton S., Sutton L. Branch retinal artery occlusion associated with sildenafil citrate // Retinal Physician. 2011.

7. Dundar S., Ozkan S. Effect of sildenafil on ocular haemodynamics // Eye. 2001. № 15. Р. 507-510.

8. El-Domyati M., El-Fakahani H. et al. Non-arteriticischaemic optic neuropathy after 36 hours of intake of sildenafil citrate // Andrologia. 2009. № 41. Р. 319-321.

9. Grunwald J. E., Siu K. K. et al. Effect of sildenafil citrate (Viagra) on the ocular circulation // Am. J. Ophthalmol. 2001. № 131. Р. 751-757.

10. Hayreh S. S., Fraterrigo L, Jonas J. Central retinal vein occlusion associated with cilioretinal artery occlusion // Retina. 2008. № 28. Р. 581-594.

11. Jagel H., Jagel C., Serely L. Visual short term effects of Viagra; Double blind study in healthy ypung subjects // Am. J. Ophthalmol. 2004. № 44. Р. 842-849.

12. Klein R., Moss S. E., Klein B. E. The 15-year cumulative incidence of retinal vein occlusion: the Beaver Dam Eye Study // Arch. Ophthalmol. 2008. № 126. Р. 513-518.

13. Kumar A., Kar S., Fay W. P. Thrombosis, physical activity, and acute coronary syndromes // J. Appl. Physiol. 2011. № 19. Р. 599-605.

14. Kurtulan E., Gulcu A. et al. Effects of sildenafil on ocular perfusion demonstrated by color Doppler ultrasonography // Int. J. Inpor. Res. 2004. № 16. Р. 244-248.

15. Laties A., Sharlip I. Ocular safety in patients using sildenafil therapy for erectile dysfunction // J. Sex Med. 2006. № 3. Р. 12-27.

16. Nawaiseh B., Shobaki A. et al. Central retinal vein occlusion after sildenafil citrate (Viagra) use // JRMS. 2006. № 13 (1). Р. 46-47.

17. Pepin S., Ian P. Stepwise decline in visual field after serial sildenafil use // J. Neuroophthalmol. 2008. № 28. Р. 76-77.

18. Querques G., Prascina F., Sarra G. M. et al. Combined central retinal vein and cilioretinalartery occlusion // Int. Ophthalmol. 2008. № 28. Р. 47-49.

19. Vicuna-Kojchtn J., Armer R., Chowers I. Sildenafil-associated consecutive nonarteritic anterior ischaemic optic neuropathy, cilioretinal artery occlusion, and central retinal vein occlusion in hemodialysis patient // Eye. 2006. № 21. Р. 127-129.


Review

For citations:


Tultseva S.N., Titarenko A.I., Nechiporenko P.A. Retinal vein occlusion after intake of sildenafil citrate. Regional blood circulation and microcirculation. 2017;16(2):70-74. (In Russ.) https://doi.org/10.24884/1682-6655-2017-16-2-70-74

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ISSN 1682-6655 (Print)
ISSN 2712-9756 (Online)