Роль оценки основных гемодинамических параметров в современной экспериментальной практике

В лекции представлен анализ данных литературы об оценке параметров системной гемодинамики в экспериментах на лабораторных животных. Освещаются вопросы влияния условий содержания, частоты контакта с человеком, хэндлинга, проведения хирургической модификации животного и фармакологического сопровождения в периоперационном периоде на артериальное давление и частоту сердечных сокращений, которые являются наиболее часто регистрируемыми параметрами как в эксперименте, так и в клинической практике. Сведения из литературных источников необходимо учитывать при планировании и подготовке эксперимента с использованием биомедицинских моделей на животных, а также при разработке и представлении протокола на биоэтической комиссии. Оценка системной гемодинамики является неотъемлемой частью физиологического мониторинга при проведении любых хирургических вмешательств на животных, что позволяет лучше стандартизировать конечные экспериментальные точки и своевременно корректировать возможные отклонения от нормы.

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