Sympathetic innervation of coronary arteries in conditions of normal coronary circulation and coronary stenosis
https://doi.org/10.24884/1682-6655-2023-22-3-4-13
Abstract
We analyzed the literature data on the role of coronary vessels’ sympathetic innervation in the regulation of the heart muscle blood circulation. We observed different effects of adrenergic influences on coronary circulation in conditions of normal epicardial arteries and in case of dynamic or organic coronary obstruction. We suggested a functional role of sympathetic influences on coronary circulation.
Keywords
About the Authors
V. A. TsyrlinRussian Federation
Tsyrlin Vitaliy A., Chief Researcher, Department of Experimental Physiology and Pharmacology, Preclinical and Translational Research Centre
2, Akkuratova str., Saint Petersburg, 197341
N. V. Kuzmenk
Russian Federation
Kuzmenko Nataliya V., Candidate of Sciences (PhD) in Biology, Senior Researcher, Department of Experimental Physiology and Pharmacology, Preclinical and Translational Research Centre; Junior Researcher, Laboratory of Blood Circulation Biophysics, Research Educational Institute of Biomedicine
2, Akkuratova str., Saint Petersburg, 197341;
6-8, L’va Tolstogo str., Saint Petersburg,197022
M. G. Pliss
Russian Federation
Pliss Mikhail G., Candidate of Sciences (PhD) in Medicine, Head of the Department of Experimental Physiology and Pharmacology, Preclinical and Translational Research Centre; Head, Laboratory of Blood Circulation Biophysics, Research Educational Institute of Biomedicine
2, Akkuratova str., Saint Petersburg, 197341;
6-8, L’va Tolstogo str., Saint Petersburg,197022
References
1. Gómez FA, Ballesteros LE. Morphologic expression of the left coronary artery in pigs. An approach in relation to human heart // Rev Bras Cir Cardiovasc. 2014;29(2):214–220. Doi: 10.5935/1678-9741.201400270.
2. Medrano-Gracia P, Ormiston J, Webster M, Beier S, Young A, Ellis C, Wang C, Smedby O, Cowan B. A computational atlas of normal coronary artery anatomy // EuroIntervention. 2016;12(7):845–854. Doi: 10.4244/EIJV12I7A139.
3. Trubetskoy AV. Physiology of blood circulation. Physiology of the vascular system. Leningrad, Science, 1984:382–406. (In Russ.)
4. Karrer HE. The striated musculature of blood vessels. I. General cell morphology // J Biophys Biochem Cytol. 1959;6(3):383–392. Doi: 10.1083/jeb.6.3.383.
5. Folkov B, Neil E. Blood circulation. Moscow, Medicine, 1976:483.
6. Cliff WJ. Blood vessels // Cambridge university press, 1976:214.
7. Gerova M, Gero J, Barta E, Dolezel S, Smiesko V, Livicky V. Neyrogenic and myogenic control of conduit coronary a.: a possible interference // Basic Res Cardiol. 1981;76(5):503–507. Doi: 10.1007/BF01908351.
8. Uchida Y, Uchida Y, MatsuyamaA, Koga A, Maezawa Y, Maezawa Y, Hiruta N. Functional medial thickening and folding of the internal elastic lamina in coronary spasm // Am J Physiol Heart Circ Physiol. 2011;300(2):H423–H430. Doi: 10.1152/ajpheart.00959.2010.
9. Ong P, Aziz A, Hansen HS, Prescott E, Athanasiadis A, Sechtem U. Structural and functional coronary artery abnormalities in patients with vasospastic angina pectoris // Circ J. 2015;79(7):1431–1438. Doi: 10.1253/circj.CJ-15-0520.
10. McRaven DR, Mark AL, Abboud FM, Mayer HE. Responses of coronary vessels to adrenergic stimuli // J Clin Invest.1971;50(4):773–778. Doi: 1172/JCI106548.
11. Vatner SF. Regulation of coronary resistance vessels and large coronary arteries // Am J Cardiol. 1985;56(9):16E– 22E. Doi: 10.1016/0002-9149(85)91171-3.
12. Feigl EO. Neural control of coronary blood flow // J Vasc Res. 1998;35(2):85–92. Doi: 10.1159/000025569.
13. Pagani M, Rimoldi O. Neural control of vasomotor tone of large coronary arteries // Can J Cardiol. 1986;(Suppl A):32A-39A.
14. Pachen M, Abukar Y, Shanks J, Lever N, Ramchandra R. Activation of the carotid bodyincreases directly recorded cardiac sympathetic nerve activity and coronary blood flow in conscious sheep // Am J Physiol Regul Integr Comp Physiol. 2021;320(3):R203–R212.
15. Cohen RA, Shepherd JT, Vanhoutte PM. Effects of the adrenergic transmitter on epicardial coronary arteries // Fed Proc. 1984;43(14):2862–2866.
16. Cohen RA, Shepherd JT, Vanhoutte PM. Prejunctional and postjunctional actions of endogenous norepinephrine at the sympathetic neuroeffector junction in canine coronary arteries // Circ Res.1983;52(1):16–25. Doi: 10.1161/01.res. 52.1.16.
17. Di Carli MF, Tobes MC, Mangner T, Levine AB, Muzik O, Chakroborty P, Levine TB. Effects of cardiac sympathetic innervation on coronary blood flow // N Engl J Med. 1997;336(17):1208–1215. Doi: 10.1056/NEJM19970 4243361703.
18. Monahan KD, Feehan RP, Sinoway LI, Gao ZJ. Contribution of sympathetic activation to coronary vasodilatation during the cold pressor test in healthy men: effect of ageing // J Physiol. 2013;591(11):2937–2947. Doi: 10.1113/ jphysiol.2013.251298.
19. Hamilton FN, Feigl EO. Coronary vascular sympathetic beta-receptor innervation // Am J Physiol. 1976;230(6):1569– 1576. Doi: 10.1152/ajplegacy.1976.230.6.1569.
20. Dolezel S, Gerová M, Hartmannová B, Vasků J. Development of the adrenergic innervation in the myocardium and coronary arteries of the dog // Acta Anat (Basel). 1990; 139(2):191–200.
21. Wu JJ, Chuang KS, Shih CJ, Liu JC. Sympathetic postganglionic innervation of the cardiac coronary artery in cats // J Auton Nerv Syst. 1988;24(3):215–220. Doi: 10.1016/0165- 1838(88)90121-x.
22. Chilian WM, Boatwright RB, Shoji T, Griggs DM. Jr. Evidence against significant resting sympathetic coronary vasoconstrictor tone in the conscious dog // Circ Res. 1981;49(4):866–876. Doi: 10.1161/01.res.49.4.866.
23. Xinhao Liu, Dan Luo, Jie Zhang, Lei Duо. Distribution and relative expression of vasoactive receptors on arteries // Sci Rep. 2020;10(1):15383. Doi: 10.1038/s41598-020-72352-5.
24. Peterson DF, Bishop VS. Influences of selective sympathetic denervation on coronary reactive hyperemia in conscious dogs // J Auton Nerv Syst. 1980;2(1):47–59. Doi: 10. 1016/0165-1838(80)90006-5.
25. Acad BA, Weiss HR. Chemical sympathectomy and utiization of coronary capillary reserve in rabbits // Microvasc Res. 1988;36(3):250–261. Doi: 10.1016/0026-2862(88)90026.
26. Mark AL, Abboud FM, Schmid PG, Heistad DD, Mayer HE. Differences in direct effects of adrenergic stimuli on coronary, cutaneous, and muscular vessels // J Clin Invest. 1972; 51(2):279–287. Doi: 10.1172/JCI106812.
27. Hodgson JM, Cohen MD, Szentpetery S, Thames MD. Effects of regional alpha- and beta-blockade on resting and hyperemic coronary blood flow in conscious, unstressed humans // Circulation. 1989;79(4):797–809. Doi: 10.1161/01.
28. Amenta C, Mione MC. Age-related changes in the noradrenergic innervation of the coronary arteries in old rats: a fluorescent histochemical study // Auton Nerv Syst. 1988; 22(3):247–251. Doi: 10.1016/0165-1838(88)90114-2.
29. Momen A, Mascarenhas V, Gahremanpour A, Gao Z, Moradkhan R, Kunselman A, Boehmer JP, Sinoway LI, Leuenberger UA. Coronary blood flow responses to physiological stress in humans // Am J Physiol Heart Circ Physiol. 2009; 296(3):H854–861. Doi: 10.1152/ajpheart.01075.2007.
30. Maman SR, Vargas AF, Ahmad TA, Miller AJ, Gao Z, Leuenberger UA, Proctor DN, Muller MD. Beta-1 vs. beta-2 adrenergic control of coronary blood flow during isometric handgrip exercise in humans // J Appl Physiol (1985). 2017; 123(2):337–343. Doi: 10.1152/japplphysiol.00106.2017.
31. Prodel E, Cavalcanti T, Rocha HNM, Gondim ML, Mira PAC, Fisher JP, Nobrega ACL. Sympathetic regulation of coronary circulation during handgrip exercise and isolated muscle metaboreflex activation in men // Exp Physiol. 2021; 106(12):2400–2411.
32. van Mil ACCM, Tymko MM, Kerstens TP, Stembridge M, Green DJ, Ainslie PN, Thijssen DHJ. Similarity between carotid and coronary artery responses to sympathetic stimulation and the role of α1-receptors in humans // J Appl Physiol (1985). 2018;125(2):409–418. Doi: 10.1152/japplphysiol.00386.2017.
33. Ross AJ, Gao Z, Pollock JP, Leuenberger UA, Sinoway LI, Muller MD. β-Adrenergic receptor blockade impairs coronary exercise hyperemia in young men but not older men // Am J Physiol Heart Circ Physiol. 2014;307(10):H1497–H1503.
34. Chilian WM, Ackell PH. Transmural differences in sympathetic coronary constriction during exercise in the presence of coronary stenosis // Circ Res. 1988;62(2):216–225. Doi: 10.1161/01.res.62.2.216.
35. Blomberg S, Emanuelsson H, Kvist H, Lamm C, Pontén J, Waagstein F, Ricksten SE. Effects of thoracic epidural anesthesia on coronary arteries and arterioles in patients with coronary artery disease // Anesthesiology. 1990;73(5):840– 847. Doi: 10.1097/00000542-199011000-00008.
36. Ricci DR, Orlick AE, Cipriano PR, Guthaner DF, Harrison DC. Altered adrenergic activity in coronary arterial spasm: insight into mechanism based on study of coronary hemodynamics and the electrocardiogram // Am J Cardiol. 1979; 43(6):1073–1079. Doi: 10.1016/0002-9149(79)90137-1.
37. Kuleshova EV, Antonova IS, Lokhovinina NL i dr. Study of the role of adrenergic vasoconstriction in the development of dynamic coronary obstruction in patients with stress-induced stenocardia // Kardiologiia. 1992;32(1):22–25. (In Russ.)
38. Longhurst JC. Coronary arteriolar vasoconstriction in myocardial ischaemia: reflexes, sympathetic nervous system, catecholamines // Eur Heart J. 1990;11(Suppl B):43–52.
39. Nakata T, Nagao K, Tsuchihashi K, Hashimoto A, Tanaka S, Iimura O. Regional cardiac sympathetic nerve dysfunction and the diagnostic efficacy of metaiodobenzylguanidine tomography in stable coronary artery disease // Am J Cardiol. 1996;78(3):292–297. Doi: 10.1016/s0002-9149(96)00280-9.
40. Takano H, Nakamura T, Satou T, Umetani K, Watanabe A, Ishihara T, Mochizuki S, Kimura H, Honma H, Ikeda Y. Regional myocardial sympathetic dysinnervation in patients with coronary vasospasm // Am J Cardiol. 1995;75(5):324– 329. Doi: 10.1016/s0002-9149(99)80547-5.
41. Deussen A, Busch P, Schipke J, Thämer V, Heusch G. Contribution of postsynaptic alpha 2-adrenoceptors to reflex sympathetic constriction of stenotic coronary vessels // Basic Res Cardiol. 1990;85(Suppl 1):193–206. Doi: 10.1007/978- 3-662-11038-616.
42. Mochizuki S, Kimura H, Honma H, Ikeda Y. Regional myocardial sympathetic dysinnervation in patients with coronary vasospasm // Am J Cardiol. 1995;75(5):324–329. Doi: 10.1016/s0002-9149(99)80547-5.
43. Kondo M, Fujiwara T, Miyazaki T, Terade M, Tabei R. Noradrenergic hyperinnervation may inhibit necrosis of coronary arterial smooth muscle cells in stroke-prone spontaneously hypertensive rats // Virchows Arch. 1997;430(1):71–75. Doi: 10.1007/BF01008019.
44. Baumgart D, Ehring T, Kowallik P, Guth BD, Krajcar M, Heusch G. Impact of alpha-adrenergic coronary vasoconstriction on the transmural myocardial blood flow distribution during humoral and neuronal adrenergic activation // Circ Res. 1993;73(5):869–886. Doi: 10.1161/01.res.73.5.869.
45. Hao Z, Jiang X, Sharafeih R, Shen S, Hand AR, Cone RE, O’Rourke J. Stimulated release of tissue plasminogen activator from artery wall sympathetic nerves: implications for stress-associated wall damage // Stress. 2005;8(2):141–149. Doi: 10.1080/10253890500168098.
46. van der Bijl P, Knuuti J, Delgado V, Bax J. Cardiac sympathetic innervation imaging with PET radiotracers // Curr Cardiol Rep. 2020;23(1):4. Doi: 10.1007/s11886-020- 01432-9.
47. Svorkdal N. Treatment of inoperable coronary disease and refractory angina: spinal stimulators, epidurals, gene therapy, transmyocardial laser, and counterpulsation // Semin Cardiothorac Vasc Anesth. 2004;8(1):43–58. Doi: 10.1177/ 108925320400800109.
48. De Vries J, De Jongste MJ, Spincemaille G, Staal MJ. Spinal cord stimulation for ischemic heart disease and peripheral vascular disease // Adv Tech Stand Neurosurg. 2007; 32:63–89. Doi: 10.1007/978-3-211-47423-5_4.
49. Nygård E, Kofoed KF, Freiberg J, Holm S, Aldershvile J, Eliasen K, Kelbaek H. Effects of high thoracic epidural analgesia on myocardial blood flow in patients with ischemic heart disease // Circulation. 2005;111(17):2165–2170. Doi: 10.1161/01.CIR.0000163551.33812.1A.
50. McCance AJ, Thompson PA, Forfar JC. Increased cardiac sympathetic nervous activity in patients with unstable coronary heart disease // Eur Heart J. 1993;14(6):751–757. Doi: 10.1093/eurheartj/14.6.751.
Review
For citations:
Tsyrlin V.A., Kuzmenk N.V., Pliss M.G. Sympathetic innervation of coronary arteries in conditions of normal coronary circulation and coronary stenosis. Regional blood circulation and microcirculation. 2023;22(3):4-13. (In Russ.) https://doi.org/10.24884/1682-6655-2023-22-3-4-13