Role of phosphorus-calcium metabolism regulators in cardiorenal syndrome development
https://doi.org/10.24884/1682-6655-2024-23-3-12-18
Abstract
Cardiorenal syndrome is a complex condition that belongs to the category of acute or chronic kidney pathology that causes cardiovascular disease, and, conversely, acute or chronic heart disease that provokes kidney dysfunction. The relationship between the pathology of the cardiovascular system and the kidneys is due to the commonality of risk factors for the pathology of both systems. In recent years, the link between regulators of mineral metabolism - vitamin D, parathyroid hormone, endocrine growth factors of fibroblasts 19,21,23, Klotho protein with the development of heart failure, atrial fibrillation, left ventricular hypertrophy, as well as the progression of chronic kidney disease has been proven. The increased levels of fibroblast growth factor-23 and a decrease in the soluble fraction of Klotho protein in plasma are recognized as early markers of chronic kidney disease and cardiovascular disease. Further study of the influence of mineral exchange regulators on cardiorenal syndrome creates a new direction in the treatment of cardiovascular diseases and chronic kidney disease.
About the Authors
N. N. Smirnova
Pavlov University
Russian Federation
Russian Federation
Smirnova Natalia N. – MD, Professor, Head, Department of Pediatrics,
6-8, L’va Tolstogo street, Saint Petersburg, 197022.
N. B. Kuprienko
Pavlov University
Russian Federation
Russian Federation
Kuprienko Natalia B. – Candidate (PhD) of Medical Sciences, Associate Professor, Department of Pediatrics,
6-8, L’va Tolstogo street, Saint Petersburg, 197022.
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Review
For citations:
Smirnova N.N., Kuprienko N.B. Role of phosphorus-calcium metabolism regulators in cardiorenal syndrome development. Regional blood circulation and microcirculation. 2024;23(3):12-18. (In Russ.) https://doi.org/10.24884/1682-6655-2024-23-3-12-18
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