Preview

Regional blood circulation and microcirculation

Advanced search

Evaluation of ocular blood flow by Doppler Ultrasound in patients with glaucoma

https://doi.org/10.24884/1682-6655-2024-23-4-22-29

Abstract

Primary open-angle glaucoma (POAG) is a neurodegenerative disease causing glaucomatous damage of the optic nerve with characteristic visual field defects. Vascular theory of the glaucoma pathogenesis considers glaucomatous optic neuropathy (GON) as a result of changes in impaired ocular blood flow (OBF). Ultrasound examination with the assessment of OBF using multifunctional ultrasonic diagnostic devices is used for evaluation of hemodynamic parameters in the retrobulbar vessels: ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary arteries (sPCA). This review presents the results of ocular blood flow studies using Doppler Ultrasound methods in patients with POAG and normal tension glaucoma (NTG). Many researchers have emphasized the important role of these methods in diagnosing and monitoring the optic nerve damage progression in glaucoma. In clinical practice, the standardization of the vascular Doppler Ultrasound technique and development of a suitable study protocol should improve the informativeness of the method and obtain reliable and reproducible results.

About the Authors

T. N. Malishevskaya
Helmholtz National Medical Research Center for Eye Diseases
Russian Federation

Malishevskaya Tatiana N. – MD, Head, Analytical Department, Associate Professor, Continuing Medical Education Department

14/19, Sadovaya-Chernogryazskaya str., Moscow, 105062



T. N. Kiseleva
Helmholtz National Medical Research Center for Eye Diseases
Russian Federation

Kiseleva Tatiana N. – MD, Professor, Head, Ultrasound department, Professor, Continuing Medical Education Departmen

14/19, Sadovaya-Chernogryazskaya str., Moscow, 105062



E. V. Renzyak
District Clinical Hospital
Russian Federation

Renzyak Ekaterina V. – Ophthalmologist, Ophthalmological Center

40, Kalinina str., Khanty-Mansiisk, 628011



References

1. Omodaka K, Kikawa T, Kabakura S, Tsuda S, Ninomiya T, Takahashi N, Pak K. Clinical characteristics of glaucoma patients with various risk factors. BMC Ophthalmol. 2022;22(1):373. Doi: 10.1186/s12886-022-02587-52.

2. Petrov SYu, Filippova OM, Malishevskaya TN, Markelova OI. Current trends and prospects of the local antihypertensive drugs development for the glaucoma treatment. Russ Ophthalmol J. 2024;17(2):154-159. (In Russ.). Doi: 10.21516/2072-0076-2024-17-2-154-159.

3. Chan KKW, Tang F, Tham CCY, Young AL, Cheung CY. Retinal vasculature in glaucoma: a review. BMJ Open Ophthalmol. 2017;1(1):e000032. Doi: 10.1136/bmjophth-2016-000032.

4. Harris A, Guidoboni G, Siesky B, Mathew S, Verticchio Vercellin AC, Rowe L, Arciero J. Ocular blood flow as a clinical observation: Value, limitations and data analysis. Prog Retin Eye Res. 2020:100841. Doi: 10.1016/j.preteyeres.2020.100841.

5. Schmetterer L, Kiel JW. Ocular blood flow. New York, Springer, 2012:147-158.

6. Nivean PD, Ariga M, Chithra M, Gohil P, Das S, Jaideep G. Efficacy of dorzolamide in improving ocular blood flow in patients with open-angle glaucoma: The Indian carbonic anhydrase inhibitor trial. 2022;70(12):4164-4167. Doi: 10.4103/ijo.IJO_1055_22.

7. Kurysheva NI. Vascular theory of the glaucomatous optic neuropathy pathogenesis: rationale in terms of ocular blood flow anatomy and physiology. Part 1. Nat J Glaucoma.2017;16(3):90-97. (In Russ.).

8. Wu X, Konieczka K, Liu X, Chen M, Yao K, Wang K, Flammer J. The role of ocular blood flow in normal tension glaucoma. Adv Ophthalmol Pract Res. 2022;2(1):100036. Doi: 10.1016/j.aopr.2022.100036.

9. Ahmad SS. Controversies in the vascular theory of glaucomatous optic nerve degeneration. Taiwan J Ophthalmol. 2016;6:182-186. Doi: 10.1016/j.tjo.2016.05.009.

10. Kiseleva TN, Zaitsev MS, Ramazanova KA, Lugovkina KV. Possibilities of color Duplex Imaging in the diagnosis of ocular vascular pathology. Russ Ophthalmol J. 2018;11(3):84-94. (In Russ.). Doi: 10.21516/2072-0076-2018-11-3-84-94.

11. Harris A, Jonescu-Cuepers C, Kagemann L, Clulla T, Krieglstein G. Ocular blood flow – vascular anatomy, pathophysiology and metabolism. Philadelphia, ButterworthHeinemann, 2003:128.

12. Kiseleva TN, Baeva AV, Eliseeva EK, Lugovkina KV. Anatomical characteristics and structural features of the optic nerve. Russ Ophthalmol J. 2024;17(1):130-135. (In Russ.). Doi: 10.21516/2072-0076-2024-17-1-130-135.

13. Zarzecki M, Obuchowska I, Ustymowicz A, Konopiń ska J. Glaucoma Surgery and Ocular Blood Flow in Colour Doppler Imaging: Is There a Link? Clin Ophthalmol. 2024;18:49-60. Doi: 10.2147/OPTH.S441805.

14. Flammer J, Orgül S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, Renard JP, Stefánsson E. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res. 2002;21:359-393. Doi: 10.1016/s1350-9462(02)00008-3.

15. Killer H, Pircher A. Normal tension glaucoma: Review of current understanding and mechanisms of the pathogenesis. Eye. 2018;32:924-930. Doi: 10.1038/s41433-018-0042-2.

16. Trivli A, Koliarakis I, Terzidou C, Goulielmos GN, Siganos CS, Spandidos DA, Dalianis G, Detorakis ET. Normaltension glaucoma: Pathogenesis and genetics. Exp Ther Med. 2019;17:563-574. Doi: 10.3892/etm.2018.7011.

17. Muller M, Kessler C, Wessel K, Mehdorn E, Kompf D. Low-tension glaucoma: a comparative study with retinal ischemic syndromes and anterior ischemic optic neuropathy Ophthal Surg. 1993;24(12):835-838. Choi J, Kook MS. Systemic and Ocular Hemodynamic Risk Factors in Glaucoma. Biomed Res Int. 2015;2015:141905. Doi: 10.1155/2015/141905.

18. Chou CC, Hsu MY, Lin CH, Lin CC, Wang CY, Shen YC, Wang IJ. Risk of developing open-angle glaucoma in patients with carotid artery stenosis: A nationwide cohort study. PLoS ONE. 2018;13(4):e0194533. Doi: 10.1371/journal.pone.0194533.

19. Funk RO, Hodge DO, Kohli D, Roddy GW. Multiple Systemic Vascular Risk Factors Are Associated With Low-Tension Glaucoma. J. Glaucoma 2022;31(1):15-22. Doi: 10.1097/IJG.0000000000001964.

20. Tarasova LN, Kiselevа TN, Fokin AA. Ocular ischemic syndrome. Moscow, Medicine, 2003:173. (In Russ.).

21. Kiseleva TN, Grigoreva EG, Tarasova LN. Glaucomatous neuropathy combined with carotid pathology: features of pathogenesis and diagnosis. Vestnik Oftalmologii. 2003;119(6):5-7. (In Russ.).

22. Lin WYu, Wang JJ, Chen Ch Y, Liu Ch Y, Lin MH, Yang YH, Lai ChH. The Relationship Between Carotid Artery Stenosis and the Development of Open-Angle Glaucoma: A Long-term Cohort Study in Taiwan. Ophthalmic Epidemiol. 2024:1-9. Doi: 10.1080/09286586.2024.2371467.

23. Gutman J, Melamed S, Ashkenazy J, Blumenthal M. Optic nerve compression by carotid arteries in low-tension glaucoma. Graefes Arch Clin Exp Opthalmol. 1993;231(12):711- 717. Doi: 10.1007/BF00919286.

24. Fan N, Wang P, Tang L, Liu X. Ocular blood flow and normal tension glaucoma. Biomed Res Int. 2015;2015:308505. Doi: 10.1155/2015/3085058.

25. Tian T, Liu YH. Normal-tension glaucoma and Alz heimer’s disease: Retinal vessel signs as a possible common underlying risk factor. Med Hypotheses. 2011;77(3):466. Doi: 10.1016/j.mehy.2011.06.039.

26. Petrov SYu, Kiseleva TN, Okhotsimskaya TD, Markelova OI. Eye microcirculation in glaucoma. Part 1. Diagnostic methods. Ophthalmology reports. 2024;17(3):113-123. (In Russ.). Doi: 10.17816/OV628995.

27. Erickson SJ, Hendrix LE, Massaro BM et al. Color Doppler flow imaging of the normal and abnormal orbit. Radiology. 1989;173(2):511-516. Doi: 10.1148/radiology.173.2.2678264.

28. Guidance for Industry and FDA staff/ Information for Manufacturers Seeking Marketing Clearance of Diagnostic Ultrasound Systems and Transducers (Appendix от 30.09.97 E). Silver Spring, 2008:64.

29. Neroev VV, Kiselevа TN, Lugovkina KV. Ultrasound in Ophthalmology : guide for doctors. 1st ed. / eds by VV Neroev, TN Kiseleva. Moscow, IKAR, 2019:324. (In Russ.).

30. Williamson T, Baxter G, Pyott A, Wykes W, Dutton GN. A comparison of Color Doppler imaging of orbital vessels and other methods of blood low assessment. Graefes Arch Clin Exp Ophthalmol. 1995;233(2):80-84. Doi: 10.1007/BF00241476.

31. Castilla-Guerra L, Gomez Escobar A, Gomez Cerezo JF. Utility of Doppler ultrasound for the study of ocular vascular disease. Rev Clin Esp (Barc). 2021;221(7):418-425. Doi: 10.1016/j.rceng.2020.11.007.

32. Banou L, Dastiridou A, Giannoukas A, Kouvelos G, Baros Ch, Androudi S. The Role of Color Doppler Imaging in the Diagnosis of Glaucoma: A Review of the Literature. Diagnostics. 2023;13(4):588. Doi: 10.3390/diagnostics13040588.

33. Tranquart F, Bergès O, Koskas P et al. Color Doppler imaging of orbital vessels: personal experience and literature review. J Clin Ultrasound. 2003;31(5):258-273. Doi: 10.1002/jcu.10169.

34. Oglat AA, Matjafri MZ, Suardi N, Oqlat MA, Abdelrahman MA, Oqlat AA. A review of medical Doppler ultrasonography of blood flow in general and especially in common carotid artery. J Med Ultrasound. 2018;26(1):3-13. Doi: 10.4103/JMU.JMU_11_17.

35. Boehm AG, Helmke K, Berry CC, Weinreb RN. Comparison of two transducers for Color Doppler Imaging of the retrobulbar vessels. J Glaucoma. 2002;11(2):148-153. Doi: 10.1097/00061198-200204000-00011.

36. Bittner M, Faes L, Boehni SC et al. Colour Doppler analysis of ophthalmic vessels in the diagnosis of carotid artery and retinal vein occlusion, diabetic retinopathy and glaucoma: systematic review of test accuracy studies. BMC Ophthalmol. 2016;16(1):214. Doi: 10.1186/s12886-016-0384-0.

37. Malishevskaya TN, Kiseleva TN, Filippova YuE, Vlasova AS, Nemtsova IV, Vasilchenko VV, Zaytsev MS. Structural and functional features of peripheral vasculature in patients with glaucoma. Russ Ann Ophthalmol. 2020;136(5):67 76. (In Russ.). Doi: 10.17116/oftalma202013605167.

38. Kurysheva NI, Kiseleva TN, Ryzhkov PK, Fomin AV, Khodak NA, Ardzhevnishvili TD. The influence of venous blood flow on the retinal ganglion cell complex in patients with primary open angle glaucoma. Ophthalmol Russ. 2013;10(1):26-31. (In Russ.). Doi: 10.18008/1816-5095-2013-1-26-31.

39. Abegão Pinto L, Willekens K, Van Keer K, Shibesh A, Molenberghs G, Vandewalle E, Stalmans I. Ocular blood flow in glaucoma – the Leuven Eye Study. Acta Ophthalmol. 2016; 94(6):592-598. Doi: 10.1111/aos.12962.

40. Krzyzanowska-Berkowska P, Czajor K, Iskander DR. Associating the biomarkers of ocular blood flow with lamina cribrosa parameters in normotensive glaucoma suspects. Comparison to glaucoma patients and healthy controls. PLoS ONE. 2021;16(3):e0248851. Doi: 10.1371/journal.pone.0248851.

41. Zegadlo A, Wierzbowska J. Colour Doppler imaging of retrobulbar circulation in different severity of glaucoma optic neuropathy. Med Ultrason. 2021;23(4):410-417.

42. Kalayci M, Tahtabasi M. Assessment of Doppler flow parameters of the retrobulbar arteries and internal carotid artery in patients with glaucoma: The significance of ophthalmic artery peak ratio and the intima-media thickness of the internal carotid artery. Int Ophthalmol. 2020;40(12):3337-3348. Doi: 10.1007/s10792-020-01520-3.

43. Eniola MA, Adeyomoye AAO, Musa KO, Ishola AAS, Olatunji OO. Ophthalmic artery and central retinal artery Doppler patterns in primary open angle glaucoma patients at the Lagos University teaching Hospital, Nigeria. J West Afr Coll Surg. 2018;8(3):1-21.

44. Calvo P, Ferreras A, Polo V, Güerri N, Seral P, FuertesLazaro I, Pablo LE. Predictive value of retrobulbar blood flow velocities in glaucoma suspects. Invest Ophthalmol Vis Sci. 2012;53(7):3875-3884. Doi: 10.1167/iovs.11-8817.

45. Magureanu M, Stanila A, Bunescu LV, Armeanu C. Color Doppler imaging of the retrobulbar circulation in progressive glaucoma optic neuropathy. Rom J Ophthalmol. 2016; 60(4):237-248.

46. Kurysheva NI, Parshunina OA, Maslova EV, Shatalova EO, Kiseleva TN, Lagutin MB. Role of eye hemoperfusion in the progress of primary open-angle glaucoma. Nat J Glaucoma. 2015;14(3):19-29. (In Russ.).

47. Jimenez-Aragon F, Garcia-Martin E, Larrosa-Lopez R, Artigas-Martín JM, Seral-Moral P, Pablo LE. Role of color Doppler imaging in early diagnosis and prediction of progression in glaucoma. Biomed Res Int. 2013;2013:871689. Doi: 10.1155/2013/871689.

48. Galassi F, Sodi A, Ucci F, Renieri G, Pieri B, Baccini M. Ocular hemodynamics and glaucoma prognosis. Arch Ophthalmol. 2003;121(12):1711-1715. Doi: 10.1001/archopht.121.12.1711.


Review

For citations:


Malishevskaya T.N., Kiseleva T.N., Renzyak E.V. Evaluation of ocular blood flow by Doppler Ultrasound in patients with glaucoma. Regional blood circulation and microcirculation. 2024;23(4):22-29. (In Russ.) https://doi.org/10.24884/1682-6655-2024-23-4-22-29

Views: 227


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1682-6655 (Print)
ISSN 2712-9756 (Online)