Assessing the Parameters of the Microvascular Bed in Healthy Individuals Using Discriminant Analysis

Abstract

Introduction. Changes in the parameters of the microvascular bed (MVB) are the most sensitive predictors that are the first to respond to pathogenic factors before the appearance of clinical symptoms. When comparing linear and volumetric blood flow indices in the MVB, obtained by high-frequency Doppler ultrasound (HFUS), in 25 healthy individuals at rest using the principal component method, the indicators of the subjects were divided into 3 groups.
The purpose of the work was on the basis of discriminant analysis (DA) to determine the most significant indicators of blood flow in the microcirculatory system that affect the division of practically healthy individuals.
Materials and methods. Based on the selected discriminant functions, three classification functions were formed, which included only those characteristics that influenced the division of the subjects. These include: maximum systolic velocity (Vs), maximum average velocity (Vm), average volume systolic velocity (Qas), maximum diastolic velocity (Vd).
As a result, according to the blood flow indices in the MVB, the subjects were divided into following groups: in group 1, the following blood flow indices were below the confidence interval (CI) (Vs=1.12 cm/s, Vm=0.77 cm/s, Vd=0.39 cm/s), while Qas=0.55 ml/min was above the CI. Group 2 is characterized by high Vm and Vd values (above 1.26 cm/s and 0.9 cm/s, respectively) with a Qas value below 0.229 ml/ min, while Vs was within the CI. Group 3 is characterized by the following values: Vs=1.89 cm/s (above the CI), Vd=0.42 cm/s (below the CI), Vm and Qas within the CI (1.17 cm/s and 0.28 ml/min, respectively).