Association of Polymorphic Markers A1298C of the MTHFR Gene with Changes in the State of the Microcirculatory Bed in Treatment of Diabetic Foot Syndrome
https://doi.org/10.24884/1682-6655-2025-24-3-45-49
Abstract
Introduction. Type 2 diabetes mellitus occupies a leading position in the structure of non-infectious diseases in the world. The development of severe vascular complications of the disease, including diabetic foot syndrome, requires complex treatment and is an economically costly process accompanied by high disability and mortality of patients.
Objective. To evaluate the association of polymorphic markers A1298C of the MTHFR gene with changes in the microcirculatory bed during the development of diabetic foot.
Materials and methods. At the 1st stage of the study, the distribution of genotypes of the A1298C polymorphism of the MTHFR gene was studied in 198 patients with uncomplicated type 2 diabetes mellitus and 199 patients with diabetic foot. At the 2nd stage of the study, 30 patients with a comparable percentage distribution of the frequencies of the studied polymorphism as at the 1st stage were selected from the general groups of patients, and their microcirculation was examined using laser Doppler flowmetry. At the 3rd stage of the study, microcirculation parameters were analyzed depending on the carriage of the genotype of the A1298C polymorphism of the MTHFR gene. Results. In patients with diabetic foot syndrome, who are carriers of the A/A and A/C genotypes, a decrease in the temporal variability of perfusion by 2 and 1.2 times was revealed at a remote point. Locally, in patients with the studied complication of type 2 diabetes mellitus and genotypes C/C, A/C, a deterioration in the general condition of the microcirculatory bed by 2 and 2.2 times was noted. A decrease in the variability of microcirculation at a point on the 1st toe in diabetic foot syndrome with carriage of the A/A and A/C genotypes by 2 and 1.8 times was recorded.
Conclusion. Carriage of different genotype variants of the A1298C polymorphism of the MTHFR gene is associated with different pathways for the implementation of mechanisms of microcirculatory bed impairment.
About the Authors
N. I. Troitskaya
Chita State Medical Academy
Russian Federation
Russian Federation
Troitskaya Natalya I. – MD, Assistant, Associate Professor, Department of Oncology
39а, Gor`kogo str., Chita, 672000
K. G. Shapovalov
Chita State Medical Academy
Russian Federation
Russian Federation
Shapovalov Konstantin G. – MD, Professor, Head, Department of Anesthesiology, Reanimation and Intensive Care
39а, Gor`kogo str., Chita, 672000
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Review
For citations:
Troitskaya N.I., Shapovalov K.G. Association of Polymorphic Markers A1298C of the MTHFR Gene with Changes in the State of the Microcirculatory Bed in Treatment of Diabetic Foot Syndrome. Regional blood circulation and microcirculation. 2025;24(3):45-49. (In Russ.) https://doi.org/10.24884/1682-6655-2025-24-3-45-49
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