Evaluation of nuclear DNA level in plasma of cardiac-surgery patients as a predictor of multiorgan dysfunction
https://doi.org/10.24884/1682-6655-2018-17-1-39-44
Abstract
The purpose of the study: to assess the significance of the nDNA plasma level in patients after cardiac surgery to predict the development of acute heart failure (AHF), acute kidney injury (AKI) and SIRS. Material and methods. The present prospective observational pilot cohort study of nDNA plasma level and the development of complications. Results. The nDNA plasma level was maximal 12 h after surgery. The level of nDNA > 20.5 ng/ml 12 h after surgery can predict risk of SIRS (sensitivity/specificity - 56/75 %); > 17.9 ng/ml - risk of AKI (79/69 %) and the AHF (62/58 %). Conclusion. The nDNA plasma level may be a predictor of early complications after cardiac surgery.
About the Authors
O. A. Grebenchikov
Moscow Regional Clinical and Research Institute
Russian Federation
Russian Federation
Yu. V. Skripkin
Moscow Regional Clinical and Research Institute
Russian Federation
Russian Federation
T. S. Zabelina
Moscow Regional Clinical and Research Institute
Russian Federation
Russian Federation
V. V. Likhvantsev
Moscow Regional Clinical and Research Institute
Russian Federation
Russian Federation
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Review
For citations:
Grebenchikov O.A., Skripkin Yu.V., Zabelina T.S., Likhvantsev V.V. Evaluation of nuclear DNA level in plasma of cardiac-surgery patients as a predictor of multiorgan dysfunction. Regional blood circulation and microcirculation. 2018;17(1):39-44. (In Russ.) https://doi.org/10.24884/1682-6655-2018-17-1-39-44
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