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Research of the peculiarities of colloidal quantum dots of AgInS2/ZnS and chitosan nanoparticles labeled with indocyanine green as the fluorescent labels for biomedical applications

https://doi.org/10.24884/1682-6655-2018-17-1-74-82

Abstract

The research is devoted to the investigating of the possibility of using colloidal quantum dots, covered by various layers and nanoparticles of chitosan labelled with indocyanin green for fluorescence imaging in vitro and in vivo. Pure quantum dots and dots in the shell synthesized from 3-aminopropyltriethoxysilane and in the shell of albumin were investigated. Research using fluorescence Visualizer IVIS Lumina LT Series III (Perkin Elmer, USA) was conducted. The possibility of using quantum dots for in vitro diagnostics, and chitosan nanoparticles - in vitro and in vivo was presented.

About the Authors

M. S. Istomina
Almazov National Medical Research Centre of the Ministry of Healthcare of the Russian Federation; Saint Petersburg Electrotechnical University «LETI»
Russian Federation


E. I. Pochkaeva
Almazov National Medical Research Centre of the Ministry of Healthcare of the Russian Federation; St. Petersburg State University
Russian Federation


D. L. Sonin
Almazov National Medical Research Centre of the Ministry of Healthcare of the Russian Federation
Russian Federation


N. A. Pechnikova
Almazov National Medical Research Centre of the Ministry of Healthcare of the Russian Federation; Saint Petersburg State Chemical Pharmaceutical Academy
Russian Federation


V. N. Postnov
Almazov National Medical Research Centre of the Ministry of Healthcare of the Russian Federation; St. Petersburg State University
Russian Federation


D. S. Mazing
Saint Petersburg Electrotechnical University «LETI»
Russian Federation


D. V. Korolev
Almazov National Medical Research Centre of the Ministry of Healthcare of the Russian Federation; Pavlov First Saint Petersburg State Medical University
Russian Federation


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Review

For citations:


Istomina M.S., Pochkaeva E.I., Sonin D.L., Pechnikova N.A., Postnov V.N., Mazing D.S., Korolev D.V. Research of the peculiarities of colloidal quantum dots of AgInS2/ZnS and chitosan nanoparticles labeled with indocyanine green as the fluorescent labels for biomedical applications. Regional blood circulation and microcirculation. 2018;17(1):74-82. (In Russ.) https://doi.org/10.24884/1682-6655-2018-17-1-74-82

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ISSN 1682-6655 (Print)
ISSN 2712-9756 (Online)