Level change features of a hypoxia-induced factor 1α in patients with critical lower limb ischemia

Introduction. Extremely topical issue of modern medicine is patients’ treatment with critical limb ischemia (CLI). Features Studying of angiogenesis at this category of patients can improve treatment results of the CLI. Aim of research. Concentration change study of hypoxia-induced factor 1α (HIF1α) in patients with CLI before and after revascularization. Materials and methods. Blood was taken from patients with CLI (n=18) with occlusive-stenotic lesions of the popliteal-tibial segment of the arteries of the lower limbs of the three vessels (vein of the foot or lower leg, the femoral artery of the affected limb, cubital vein) to studying of change of concentration HIF1α before and after endovascular revascularization. Also the blood was taken from healthy volunteers (n=10). Results. All patients had resolution of CLI after endovascular revascularization. Indicators of a HIF1α didn’t differ in different vessels of healthy volunteers and patients with CLI before and after endovascular revascularization (р>0.05). Concentration of a HIF1α statistically significantly decreased at patients with a CLI after endovascular revascularization (р<0.0001). Concentration of a HIF1α didn’t differ in patients with a diabetes mellitus type II and without it (р>0.05). Conclusions. It is expedient to release blood sampling for concentration study of a HIF1α from cubital vein or other available vein of the upper limb. Technically successful operation of revascularization with resolution of CLI is characterized by depression of concentration of a HIF1α that can show recovery of limb tissue perfusion. The diabetes mellitus type II doesn’t affect the change of HIF1α concentration in patients with a CLI.

критическая ишемия нижних конечностей, гипоксией-индуцированный фактор, ангиогенез, облитерирующий атеросклероз сосудов нижних конечностей, сахарный диабет, critical limb ischemia, hypoxia-inducible factor, angiogenesis, atherosclerosis obliterans of lower limb vessels, diabetes mellitus

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