The use of optical coherence tomography imaging of the vascular wall of the coronary arteries before and after stenting
https://doi.org/10.24884/1682-6655-2019-18-1-77-85
Abstract
Introduction. Optical coherence tomography (OCT) is an intravascular imaging method that allows to evaluate the structure of the vascular wall, as well as to monitor the process of stent installation and healing.
The aim of this work was to identify factors affecting neointimal vascular healing after implantation of drugeluting stents.
Material and methods. In 35 patients with acute coronary syndrome without ST elevation, everolimuseluted stents with permanent and biodegradable polymer were installed. After 6 months patients underwent control coronary angiography with OCT, the state of neointima of previously implanted stents was analyzed. Clinical, anamnestic and laboratory parameters were evaluated.
Results. 28750 struts of stents were analyzed and the healing score was calculated. The healing score depended on the patient’s age (r=0.60710, p=0.0003), a history of diabetes mellitus (p=0.0477), current myocardial infarction (p=0.0183), and the degree of coronary artery disease (p=0.0355). The healing score was signifcantly lower in patients with a Syntax score <22 (p=0.004).
Conclusion. The results of the research showed that main factors that impair neointimal healing are age, the presence of diabetes, the characteristics of the lesion of the coronary arteries; they may affect the duration of dual antiplatelet therapy.
About the Authors
I. S. Trusov
Academician I. P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
Trusov Ivan S. – Cardiologist of the admission department № 1 of the Research Institute of Surgery and Emergency Medicine, Assistant of the Faculty Therapy Department with a course of endocrinology, cardiology and functional diagnostics with a clinic
197022, Saint-Petersburg, L’va Tolstogo street, 6-8
E. M. Nifontov
Academician I. P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
Nifontov Evgeniy M. – Ph. D., Professor of the Faculty Therapy Department with a course of endocrinology, cardiology and functional diagnostics with a clinic, Head of the Emergency Cardiology Laboratory of the Research Institute of Cardiovascular Diseases
197022, Saint-Petersburg, L’va Tolstogo street, 6-8
A. V. Biryukov
Academician I. P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
Biryukov Alexey V. – PhD, Head of the Department of X-ray Surgical Diagnostic and Treatment Methods No. 1 of the Research Institute of Surgery and Emergency Medicine
197022, Saint-Petersburg, L’va Tolstogo street, 6-8
R. D. Ivanchenko
Academician I. P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
Ivanchenko Roman D. – doctor of the department of x-ray diagnostic methods and treatment No. 1 of the Research Institute of Surgery and Emergency Medicine
197022, Saint-Petersburg, L’va Tolstogo street, 6-8
E. I. Melioranskaia
Academician I. P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
Melioranskaia Ekaterina I. – cardiologist of the cardiology department № 1 of the Institute of Cardiovascular Diseases
197022, Saint-Petersburg, L’va Tolstogo street, 6-8
V. V. Dobrovolskiy
Academician I. P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
Dobrovolskiy Vadim V. – 6th year student of medical faculty
197022, Saint-Petersburg, L’va Tolstogo street, 6-8
T. V. Gulyaeva
Academician I. P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
Gulyaeva Tatyana V. – 6th year student of medical faculty
197022, Saint-Petersburg, L’va Tolstogo street, 6-8
O. E. Ivleva
Academician I. P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
Ivleva Olga E. – 6th year student of medical faculty
197022, Saint-Petersburg, L’va Tolstogo street, 6-8
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Review
For citations:
Trusov I.S., Nifontov E.M., Biryukov A.V., Ivanchenko R.D., Melioranskaia E.I., Dobrovolskiy V.V., Gulyaeva T.V., Ivleva O.E. The use of optical coherence tomography imaging of the vascular wall of the coronary arteries before and after stenting. Regional blood circulation and microcirculation. 2019;18(1):77-85. (In Russ.) https://doi.org/10.24884/1682-6655-2019-18-1-77-85
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