Microcirculation of the lungs in acute pulmonary edema
https://doi.org/10.24884/1682-6655-2019-18-1-96-103
Abstract
Introduction. The relevance of the work is determined by the high mortality in acute pulmonary edema (APE), the speed of development of the process, the lack of effective methods of treatment and comprehensive studies of acute pulmonary edema used in vivo methods of research.
The aim of this work was to study the pathogenesis of APE in the experiment using biomicroscopy.
Material and methods. The microcirculation of lungs was studied in the dynamics of APE by direct and indirect methods: biomicroscopy of lungs using the chamber of the rat, laser Doppler flowmetry of the lungs, morphological and histological examination of lungs.
Results. The decisive role of lymphatic microvessels in the pathogenesis of APE was shown. All studied indicators complemented each other and were the result of impaired microcirculation in the blood and lymph microvasculature of the lungs. In the surviving animals with APE, there was an initial recovery of lymph flow in the lungs. Restoration of venular tone, reduction of edema in the interstitium of the lungs and morphological manifestations occurred after restoration of lymphocirculation, which is in favor of the decisive role of the lymphatic system in the pathogenesis of APE. It is necessary to create pharmacological agents with lymphstimulating activity.
About the Authors
D. V. Sultanov
Institute of General Pathology and Pathophysiology
Russian Federation
Russian Federation
Sultanov Delyus V.– Ph. D., junior researcher
125315, Moscow, Baltic street, 8
V. K. Khugayeva
Institute of General Pathology and Pathophysiology
Russian Federation
Russian Federation
Khugayeva Valentina K. – MD, Ph. D.
125315, Moscow, Baltic street, 8
A. V. Ardasenov
Institute of General Pathology and Pathophysiology
Russian Federation
Russian Federation
Ardasenov Alan V. – Candidate of Medical Sciences, Senior Researcher
125315, Moscow, Baltic street, 8
A. A. Kovalenko
Institute of General Pathology and Pathophysiology;
Russian Federation
Russian Federation
Kovalenko Alexey A. – Doctor of the sanatorium «Zvenigorod», First Moscow State Medical University named after I. M. Sechenov» (formerly N. S. Institute of General Pathology and Pathophysiology)
125315, Moscow, Baltic street, 8,
119991, Moscow, Trubeckaya street, 8
A. M. Zaseeva
Institute of General Pathology and Pathophysiology
Russian Federation
Russian Federation
Zaseeva Alana M. – mns
125315, Moscow, Baltic street, 8
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Review
For citations:
Sultanov D.V., Khugayeva V.K., Ardasenov A.V., Kovalenko A.A., Zaseeva A.M. Microcirculation of the lungs in acute pulmonary edema. Regional blood circulation and microcirculation. 2019;18(1):96-103. (In Russ.) https://doi.org/10.24884/1682-6655-2019-18-1-96-103
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