Analysis of stromal-vascular markers of tubulointerstitium in patients with IgA-nephropathy
https://doi.org/10.24884/1682-6655-2014-13-4-58-66
Abstract
The aim of this study was to investigate the status and relationships the elements of stromal-vascular tubulointerstisial compartment (TIN) of the kidneys under IgA-nephropathy by analyzing clinical and morphological markers, including factor coefficient obstruction of the arteries. The study included 15 patients with confirmed morphologically diagnosis of IgA-nephropathy (IgAN). All patients were performed laboratory and pathological studies, including immunohistochemistry (α-SMA, CD31, PCNA, TGFβ-1) and quantitative/semi-quantitative assessment of pathohistopathological changes: atrophy of tubules (AT), local sclerosis (LS), perivascular sclerosis, sclerosed glomeruli (SG), the coefficient of obstruction (CO) arteries with a diameter greater than 100 microns. Serum creatinine was inversely negative correlation with CO (r=-0.83, p<0.05). and positive perivascular sclerosis (r=0.64, p<0.05). Correlation analysis of the values of CD 31 «+» and SMA in patients IgAN certified statistically significant positive correlation of morphometric parameters (r=0.53, p<0.05). This is confirmed by the same values and correlation analysis SMA and TGFβ (r=0.71, p<0.05) among themselves, as well as with the AT (r=0.77, p<0.05) and LS (r=0.77, p<0.05). The results indicate that the fibrotic processes in TIN under IgAN may be due not only to immune complex processes, but only to the changes in the structure of arteries, and thus the hemodynamic changes into the renal parenchyma.
About the Authors
V. G. Sipovskii
First St. Petersburg State Medical University I.P Pavlov
Russian Federation
Russian Federation
V. A. Titova
First St. Petersburg State Medical University I.P Pavlov
Russian Federation
Russian Federation
E. B. Sipovskaya
First St. Petersburg State Medical University I.P Pavlov
Russian Federation
Russian Federation
R. V. Zverkov
First St. Petersburg State Medical University I.P Pavlov
Russian Federation
Russian Federation
A. V. Smirnov
First St. Petersburg State Medical University I.P Pavlov
Russian Federation
Russian Federation
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Review
For citations:
Sipovskii V.G., Titova V.A., Sipovskaya E.B., Zverkov R.V., Smirnov A.V. Analysis of stromal-vascular markers of tubulointerstitium in patients with IgA-nephropathy. Regional blood circulation and microcirculation. 2014;13(4):58-66. (In Russ.) https://doi.org/10.24884/1682-6655-2014-13-4-58-66
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