Changes in elastic skeleton of abdominal aorta under modeling of different types of chronic stress in experiment and possibilities of their correction by enalapril

Article describes changes in elastic skeleton of the aortic tunica media under modeling of different types of chronic stress. In the experimental study on male Wistar rats, two versions of the model of chronic stress were used: 1) by a two-week intraperitoneal administration of epinephrine (chronic adrenergic stress) and 2) anticholinesterase inhibitor neostigmine (chronic cholinergic stress). The authors have shown that in both cases of chronic stress there was a significant decrease of elastin content in the wall of the abdominal aorta, and the proportion of areas with elastin density ≥ 50 vol % after 2 weeks of administration of neostigmine was significantly less than after 2 weeks of administration of epinephrine, which suggests that elastin degradation is more pronounced in chronic cholinergic stress. Changes in elastic skeleton persist even 1 month after cessation of modeling of both types of stress. It was revealed that two-week introduction of angiotensin inhibitor enalaprilate simultaneously with epinephrine or neostigmine does not prevent changes in elastic skeleton of aorta. In both cases, statistically reliable reduction of elastin content was noted.

ремоделирование, хронический адренергический стресс, хронический холинергический стресс, аорта, эластин, энап, adrenergic stress, chronic cholinergic stress, aorta, elastin, enalaprilate

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