Valuation of myocardial blood supply and metabolism after autologous bone marrow mononuclear cells intracoronary infusion

Purpose. Morbidity and mortality remain are still high in patients with coronary artery disease, especially in patients with recurrent angina pectoris after coronary artery bypass grafting (CABG) and distal atherosclerosis. The evaluation of myocardial blood supply and metabolism was performed after intracoronary autologous bone marrow mononuclear cells infusion in patients with CAD who are not suitable for CABG. Design/Methodology/Approach. Functional class of angina pectoris (CCS), nitroglycerine consumption, exercise test and 6-min walk test were determined. In addition, following instrumental methods were applied: coronarography, single-photon emission computed tomography and positron emission tomography. Findings. The functional class of angina pectoris and the nitroglycerine consumption decreased in one year follow-up of patients, who resieved treatment with intracoronary autologous bone marrow mononuclear cells infusion. Meanwhile, the tolerance to physical activity, the myocardial blood supply and the metabolism increased in patients with CAD. Conclusion. Autologous bone marrow mononuclear cells intracoronary infusion improves myocardial blood supply and metabolism in patients with coronary artery disease who are not suitable for CABG.

стволовые клетки, ИБС, кровоснабжение, перфузия, метаболизм, мононуклеары, костный мозг, cells, ischemic disease, blood supply, perfusion, metabolism, mononuclear cells, bone marrow

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