Dynamics of regional hemodynamics and microvascular reactivity against the use of modified methods of extracorporeal hemacorrection in patients with gout

The close relationship between the gout and the cardiovascular disorder has no doubt. However the effect of uric acid on microcirculation disorders in this category of patients is still poorly studied. The aim of this research was to learn the contribution of gout in the disturbance of peripheral blood flow and adaptation reserve of microcirculation system in patients with cardiovascular disorders, as well as to evaluate the possibility of their correction using methods of efferent therapy. During the first stage 60 patients with hypertensive and coronary artery heart diseases associated with primary gout were examined. The comparison group consisted of 70 patients with hypertensive and coronary artery heart diseases, without concomitant gout, matched by sex, age and cardiovascular disease duration flow. The high-frequency ultrasound dopplerography and a complex of functional tests (postural, hypercapnic, hyperventilation, cold) were used to estimate the state of microcirculation. During the second stage 28 patients with steadily progressive course of the gout were examined to evaluate the effect of the combination of plasmapheresis with plasma exchange cryosorption autoplasma. Observable parameters were determined before and after the course of efferent therapy. It was found that patients with cardiovascular disease have disturbed exchange purines which corresponds to more expressed distress regional hemodynamics. Disorders of regulation processes of tissue blood flow might be mediated by hyperuricemia. Course application of Extracorporeal Hemacorrection is not only an effective method of reducing uric acid, but also can significantly improve the speed performance of the microcirculation and increase its adaptive reserve.

подагра, кардиоваскулярная патология, микроциркуляция, высокочастотная ультразвуковая допплерография, сосудистая реактивность, экстракорпоральная гемокоррекция, gout, cardiovascular disorder, microcirculation, high-frequency ultrasound dopplerography, vascular reactivity, extracorporeal haemocorrection

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