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Morphological studies of stented coronary artery bifurcations on anatomical preparations of the heart

https://doi.org/10.24884/1682-6655-2019-18-3-29-34

Abstract

Introduction. One of the most difficult and completely unsolved problems of modern interventional cardiology is bifurcation stenting of the coronary arteries. This problem requires a comprehensive study, including using the possibility of morphological analysis.

Material and methods. Stenting of the bifurcation lesions of the coronary arteries on 46 cadaveric hearts was performed using the bifurcation and conventional stents with subsequent plating and study of the preparations obtained.

Results. From the point of view of the safety of the lateral branch, T-stenting is optimal, especially when implanting a BIOSS stent. When using the Tryton stent with the culotte stenting technique, there was never a stenosis of the side branch, due to the stent in the lumen, but there was always an excessive metal saturation in the main branch before the bifurcation. When using conventional stent with a provisional T-stenting technique residual, stenosis of the mouth of the lateral branch was also observed. In addition, in all cases there was a deformation of the stent beams near the mouth of the lateral branch.

Conclusions. Morphological studies of stented coronary arteries on anatomical preparations of the heart, plastized with epoxy resin, make it possible to obtain new results that cannot be obtained with traditional morphological and clinical research methods (histological, corrosive, radiological, etc.).

 

 

About the Authors

D. A. Starchik
Pavlov University
Russian Federation
Ph. D., Associate Professor, Department of Clinical Anatomy and Operative Surgery named after prof. M. G. Priveza


K. L. Kozlov
St. Petersburg Institute of Bioregulation and Gerontology of the North-West Branch of the Russian Academy of Medical Sciences
Russian Federation
Ph. D., Professor, laboratory of age-related pathology of the cardiovascular system


A. N. Shishkevich
Military Medical Academy named after S. M. Kirov
Russian Federation
Ph. D., head of the X-ray surgical department of the Surgery Clinic (Improvements of Doctors) № 1


S. S. Mikhailov
Military Medical Academy named after S. M. Kirov
Russian Federation
Ph. D., senior resident of the X-ray surgery department of the surgery clinic (improvement of doctors) № 1


Z. M. Abdullaev
Military Medical Academy named after S. M. Kirov
Russian Federation
cardiovascular surgeon of the X-ray surgical department of the Surgery Clinic (Improvements of Doctors) № 1


O. O. Volikov
Military Medical Academy named after S. M. Kirov
Russian Federation
cardiovascular surgeon of the X-ray surgical department of the Surgery Clinic (Improvements of Doctors) № 1


E. I. Umancev
Military Medical Academy named after S. M. Kirov
Russian Federation
cardiovascular surgeon of the X-ray surgical department of the Surgery Clinic (Improvements of Doctors) № 1


E. J. Bessonov
Military Medical Academy named after S. M. Kirov
Russian Federation
6th year student 2 faculties of training doctors (for the Rocket, Ground and Airborne Forces)


References

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2. Nerlekar N, Francis JH, Kunal PV et al. Percutaneous Coronary Intervention Using Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Unprotected Left Main Coronary Artery Stenosis: A Meta-Analysis of Randomized Trials. Circ. Cardiovasc. Interv. 2016;9:47–49. Doi: 10.1161/ circinterventions.116.004729.

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4. Shishkevich AN, Kravchuk VN, Kozlov KL et al. Rentgenjendovaskuljarnoe lechenie bifurkacionnyh porazhenij koronarnyh arterij u pacientov pozhilogo i starcheskogo vozrasta: obzor literatury № 1. Uspehi gerontologii. 2014;27(3):510–518. (In Russ.).

5. Shishkevich AN, Kravchuk VN, Kozlov KL et al. Rentgenjendovaskuljarnoe lechenie bifurkacionnyh porazhenij koronarnyh arterij u pacientov pozhilogo i starcheskogo vozrasta: obzor literatury № 2. Uspehi gerontologii. 2014;27(4):716–719. (In Russ.).

6. Weinstein JS, Baim DS, Sipprely ME et al. Salvage of branch vessels during bifurcation lesion angioplasty: acute and long-term follow-up. Cathet. Cardiovasc. Diagn. 1991;22:1–6. Doi: 10.1002/ccd.1810220102.

7. Starchik DA. Metodicheskie osnovy plastinacii raspilov tela. Morfologija. 2015;148(4):56–61. (In Russ.).

8. Sora MC, Cook P. Epoxy plastination of biological tissue: E12 technique. J. Int. Soc. Plastination. 2007;22:31–39. Doi: 10.1111/j.1741-4520.2009.00225.x.

9. Patent na izobretenie № 2664628 RF. Sposob vizualizacii metallicheskih stentov v koronarnyh arterijah. Starchik DA, Shishkevich AN, Hubulava GG et al. (In Russ.).

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11. Nerlekar N, Francis JH, Kunal PV et al. Percutaneous Coronary Intervention Using Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Unprotected Left Main Coronary Artery Stenosis: A Meta-Analysis of Randomized Trials. Circ. Cardiovasc. Interv. 2016;9:47–49. Doi: 10.1161/ circinterventions.116.004729.

12. Biondi-Zoccai GG, Lotrionte M, Moretti C et al. A collaborative systematic review and meta-analysis on 1278 patients undergoing percutaneous drug-eluting stenting for unprotected left main coronary artery disease. Am. Heart. J. 2008;155:274-283. Doi: 10.1108/cgij.2009.24814cae.014.

13. Шишкевич А. Н., Кравчук В. Н., Козлов К. Л. и др. Рентгеноэндоваскулярное лечение бифуркационных поражений коронарных артерий у пациентов пожилого и старческого возраста: обзор литературы № 1 // Успехи геронтологии. – 2014. – T. 27, № 3. – С. 510–518. [Shishkevich AN, Kravchuk VN, Kozlov KL et al. Rentgenjendovaskuljarnoe lechenie bifurkacionnyh porazhenij koronarnyh arterij u pacientov pozhilogo i starcheskogo vozrasta: obzor literatury № 1. Uspehi gerontologii. 2014;27(3):510–518. (In Russ.)].

14. Шишкевич А. Н., Кравчук В. Н., Козлов К. Л. и др. Рентгеноэндоваскулярное лечение бифуркационных поражений коронарных артерий у пациентов пожилого и старческого возраста: обзор литературы № 2 // Успехи геронтологии. – 2014. – T. 27, № 4. – С. 716–719. [Shishkevich AN, Kravchuk VN, Kozlov KL et al. Rentgenjendovaskuljarnoe lechenie bifurkacionnyh porazhenij koronarnyh arterij u pacientov pozhilogo i starcheskogo vozrasta: obzor literatury № 2. Uspehi gerontologii. 2014;27(4):716–719. (In Russ.)].

15. Weinstein JS, Baim DS, Sipprely ME et al. Salvage of branch vessels during bifurcation lesion angioplasty: acute and long-term follow-up. Cathet. Cardiovasc. Diagn. 1991;22:1–6. Doi: 10.1002/ccd.1810220102.

16. Старчик Д. А. Методические основы пластинации распилов тела // Морфология. – 2015. – T. 148, № 4. – С. 56–61. [Starchik DA. Metodicheskie osnovy plastinacii raspilov tela. Morfologija. 2015;148(4):56–61. (In Russ.)].

17. Sora MC, Cook P. Epoxy plastination of biological tissue: E12 technique. J. Int. Soc. Plastination. 2007;22:31–39. Doi: 10.1111/j.1741-4520.2009.00225.x.

18. Патент на изобретение № 2664628 РФ. Способ визуализации металлических стентов в коронарных артериях / Д. А. Старчик, А. Н. Шишкевич, Г. Г. Хубулава и др. [Patent na izobretenie № 2664628 RF. Sposob vizualizacii metallicheskih stentov v koronarnyh arterijah. Starchik DA, Shishkevich AN, Hubulava GG et al. (In Russ.)].

19. Оганов Р. Г., Алекян Б. Г., Аронов Д. М. и др. Болезни сердца: рук. для врачей. – М., 2006. – 1326 с. [Oganov RG, Alekjan BG, Aronov DM et al. Bolezni serdca. Rukovodstvo dlja vrachej. Moscow, 2006:1326. (In Russ.)].

20. Nerlekar N, Francis JH, Kunal PV et al. Percutaneous Coronary Intervention Using Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Unprotected Left Main Coronary Artery Stenosis: A Meta-Analysis of Randomized Trials. Circ. Cardiovasc. Interv. 2016;9:47–49. Doi: 10.1161/ circinterventions.116.004729.

21. Biondi-Zoccai GG, Lotrionte M, Moretti C et al. A collaborative systematic review and meta-analysis on 1278 patients undergoing percutaneous drug-eluting stenting for unprotected left main coronary artery disease. Am. Heart. J. 2008;155:274-283. Doi: 10.1108/cgij.2009.24814cae.014.

22. Шишкевич А. Н., Кравчук В. Н., Козлов К. Л. и др. Рентгеноэндоваскулярное лечение бифуркационных поражений коронарных артерий у пациентов пожилого и старческого возраста: обзор литературы № 1 // Успехи геронтологии. – 2014. – T. 27, № 3. – С. 510–518. [Shishkevich AN, Kravchuk VN, Kozlov KL et al. Rentgenjendovaskuljarnoe lechenie bifurkacionnyh porazhenij koronarnyh arterij u pacientov pozhilogo i starcheskogo vozrasta: obzor literatury № 1. Uspehi gerontologii. 2014;27(3):510–518. (In Russ.)].

23. Шишкевич А. Н., Кравчук В. Н., Козлов К. Л. и др. Рентгеноэндоваскулярное лечение бифуркационных поражений коронарных артерий у пациентов пожилого и старческого возраста: обзор литературы № 2 // Успехи геронтологии. – 2014. – T. 27, № 4. – С. 716–719. [Shishkevich AN, Kravchuk VN, Kozlov KL et al. Rentgenjendovaskuljarnoe lechenie bifurkacionnyh porazhenij koronarnyh arterij u pacientov pozhilogo i starcheskogo vozrasta: obzor literatury № 2. Uspehi gerontologii. 2014;27(4):716–719. (In Russ.)].

24. Weinstein JS, Baim DS, Sipprely ME et al. Salvage of branch vessels during bifurcation lesion angioplasty: acute and long-term follow-up. Cathet. Cardiovasc. Diagn. 1991;22:1–6. Doi: 10.1002/ccd.1810220102.

25. Старчик Д. А. Методические основы пластинации распилов тела // Морфология. – 2015. – T. 148, № 4. – С. 56–61. [Starchik DA. Metodicheskie osnovy plastinacii raspilov tela. Morfologija. 2015;148(4):56–61. (In Russ.)].

26. Sora MC, Cook P. Epoxy plastination of biological tissue: E12 technique. J. Int. Soc. Plastination. 2007;22:31–39. Doi: 10.1111/j.1741-4520.2009.00225.x.

27. Патент на изобретение № 2664628 РФ. Способ визуализации металлических стентов в коронарных артериях / Д. А. Старчик, А. Н. Шишкевич, Г. Г. Хубулава и др. [Patent na izobretenie № 2664628 RF. Sposob vizualizacii metallicheskih stentov v koronarnyh arterijah. Starchik DA, Shishkevich AN, Hubulava GG et al. (In Russ.)].


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For citations:


Starchik D.A., Kozlov K.L., Shishkevich A.N., Mikhailov S.S., Abdullaev Z.M., Volikov O.O., Umancev E.I., Bessonov E.J. Morphological studies of stented coronary artery bifurcations on anatomical preparations of the heart. Regional blood circulation and microcirculation. 2019;18(3):29-34. (In Russ.) https://doi.org/10.24884/1682-6655-2019-18-3-29-34

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