Aorta and major arteries calcinosis: pathobiological mechanisms and clinical significance
https://doi.org/10.24884/1682-6655-2012-11-2-4-10
Abstract
The present review is devoted to the problem of the aorta and major arteries wall calcification. In this paper the comparative description of different types of calcinosis is presented. The main notice of article is focused on the intimal- and mediacalcinosis (Monckeberg's sclerosis) as a kinds with a more common incidence in general population. Through the literatures data, possibly causes and pathogenetic mechanisms of calcinosis are described. The great attention is given to a clinical value of an abdominal aorta wall calcinosis. In conclusion, the relationship between abdominal aortic calcification and high risk of cardiovascular events is analyzed.
About the Authors
M. V. Melnikov
General surgery department of the Northwest state medical university named after I. I. Mechnikov
Russian Federation
Russian Federation
A. E. Barsukov
General surgery department of the Northwest state medical university named after I. I. Mechnikov
Russian Federation
Russian Federation
V. A. Zelinskiy
General surgery department of the Northwest state medical university named after I. I. Mechnikov
Russian Federation
Russian Federation
A. U. Apresyan
General surgery department of the Northwest state medical university named after I. I. Mechnikov
Russian Federation
Russian Federation
References
1. Вихерт, А. М. Кальциноз артерий аорты и коронарных сосудов / А. М. Вихерт, К. Р. Седов, Р. И. Соколова. - М.: Медицина, 1970. - 152 с.
2. Abedin, M. Vascular calcification. Mechanisms and clinical ramifications / M. Abedin, Y. Tintut, L. L. Demer // Arteriocler. Tromb. Vasc. Biol. - 2004. - № 24 (7). - Р. 1161-1170.
3. Acierno, L. J. Atherosclerosis (arteriosclerosis) / L. J. Acierno [et al] // The History of Cardiology. - N.-Y.: Parthenon Publishing Group Inc., 1994. - Р. 109-126.
4. Allison, M. A. Patterns and riskfactor for systematic calcified atherosclerosis / M. A. Allison, M. H. Criqui, C. M. Wright // Arterioscler. Thromb. Vasc. Biol. - 2004. - № 24 (2). - Р. 331-336.
5. An, J. Estradiol repression of tumor necrosis factor-transcription requires estrogen receptor activation function-2 and is enhanced by coactivators / J. An [et al] // Proc. Natl. Acad. Sci. USA. - 1999. - № 96. - Р. 15161-15166.
6. Ballota, E. Patency and limb salvage rates after distal revascularization to unclampable calcified outflow arteries / E. Ballota [et al] // J. Vasc. Surg. - 2004. - № 39 (3). - Р 539-546.
7. Bobryshev, Y. V. Calcified deposit formation in intimal thickenings of the human aorta / Y. V. Bobryshev, R. S. Lord, A. A. Warren // Atheroscler. - 1995. - № 118. - Р. 9-21.
8. Bostrom, K. Bone morphogenicprotein expression in human atherosclerotic lesions / K. Bostrom [et al] // J. Clin. Invest. - 1993. - № 91. - Р. 1800-1809.
9. Biigel, S. Vitamin K and bone health / S. Biigel // Proc. Nutr. Soc. - 2003. - № 62. - Р. 839-843.
10. Chen, N. X High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells / N. X Chen [et al] // Nephrol. Dial. Transplant. - 2006. - № 21. - Р. 3435-3442.
11. Demer, L. L. Vascular calcification pathobiology of a multifaceted disease / L. L. Demer, Y. Tintut // Circulation. - 2008. - № 117. - Р. 2938-2948.
12. Di Martino, Е. Biomechanics of abdominal aortic aneurysm in the presence ofendolumina thrombus; experimental characterize ion and structural static computational analysis / E. Di Martino [et al] // Eur J. Vas. Endovasc. Surg. - 1998. - № 15 (4). - Р. 290-299.
13. Doherty, T. M. Genetic determinants of arterial calcification associated with atherosclerosis / T. M. Doherty // Mayo Clin. Proc. - 2004. - № 79 (2). - Р. 197-210.
14. Doherty, T. M. Molecular, endocrine and genetic mechanisms of arterial calcification / T. M. Doherty [et al] // Endocr. Rev. - 2004. - № 25 (4). - Р. 629-672.
15. Ehlermann, P. Predictive value of inflammatory and hemostatic parameters, atherosclerotic riskfactors, and chest X-ray for aortic arch atheromatosis / P. Ehlermann [et al] // Stroke. - 2004. - № 35 (1). - Р. 34-39.
16. El-Abbadi, M. Mechanisms of vascular calcification / M. El-Abbadi, C. M. Giachelli // Adv. Chronic. Kid. Dis. - 2007. - № 14. - Р. 54-66.
17. Elliott, R. J. Calcification of the human thoracic aorta during aging / R. J. Elliott, L. T. McGrath // Calcif. Tissue. Int. - 1994. - № 54. - Р. 268-273.
18. Faxon, D. P. Atherosclerotic vascular disease: executive summary: atherosclerotic vascular conference proceeding for healthcare professional from a special writing group of the American Heart Assotiation / D. P. Faxon [et al] // Circulation. - 2004. - № 109. - Р. 2595-2604.
19. Fleckenstein-Grun, G. Differentiation between calcium- and cholesterol-dominated types of atherosclerotic lesions: antiatheriosclerotic aspects of calcium antagonists / G. Fleckenstein-Grun [et al] //J. Cardiovasc. Pharm. - 1991. - № 18 (6). - Р. S1-9.
20. Galien, R. Involvement of CCAAT/enhancer-binding protein and nuclear factor-B binding sites in interleukin-6 promoter inhibition by estrogens / R. Galien, H, F. Evans, T. Garcia // Mol. Endocrinol. - 1996. - № 10. - Р. 713-722.
21. Giachelli, C. M. Vascular calcification mechanisms / B. M. Giachelli // J. Am. Soc. Nephrol. - 2004. - № 15. - Р 2959-2964.
22. Giachelli, C. M. Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques / C. M. Giachelli [et al] // J. Clin. Invest. - 1993. - № 92. - Р. 686-1696.
23. Hoshino, T. Mechanical stress analysis of a rigid inclusion in distensible material: a model of atherosclerotic calcification and plaque vulnerability / T. Hoshino [et al] // Am. J. Physiol. Heart. Circ. Physiol. - 2009. - № 297 (2). - Р. H802-H810.
24. Irribarren, C. Calcification of the aortic arch: risk factor and association with coronary heart disease, stroke, and peripheral vascular disease / C. Irribarren [et al] // JAMA. - 2000. - № 283 (21). - Р. 2810-2815.
25. Jono, S. Phosphate regulation of vascular smooth muscle cell calcification / S. Jono [et al] // Circ Res. - 2000. - № 87. - Р. E10-E17.
26. Lederle, F. A. Prevalence and associations of abdominal aortic aneurysm detected through screening. Aneurysm Detection and Management (ADAM) veterans affairs cooperative study group / F. A. Lederle [et al] // Ann. Intern. Med. - 1997. - № 126 (6). - Р. 441-449.
27. Levy, R. J. Biologic determinants of dystrophic calcification and osteocalcin deposition in glutaraldehyde-preservedporcine aortic valve leaflets implantedsubcutaneously in rats / R. J. Levy [et al] // Am. J. Pathol. - 1983. - № 113. - Р. 143-155.
28. Ludewig, B. Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model / B. Ludewig [et al] // Proc. Natl. Acad. Sci. USA. - 2000. - № 97. - Р. 12752-12757.
29. Lusis, A. J. Atherosclerosis / A. J. Lusis // Nature. - 2000. - № 14. - Р. 233-241.
30. McCullough, P. A. Accelerated atherosclerotic calcification and Monckeberg's sclerosis: a continuum of advanced vascular pathology in chronic kidney disease / P. A. McCullough [et al] // Clin. J. Am. Soc. Nephrol. - 2008. - № 3. - Р. 1585-1598.
31. McDermott, M. M. Ankle-brachial index and subclinical cardiac and carotid disease: The multiethnic study of atherosclerosis / M. M. McDermott [et al] // Am. J. Epidemiol. - 2005. - № 162. - Р. 33-41.
32. Misare, B. D. Infrapopliteal bypasses to severely calcified, unclampable outflow arteries: two-year results / B. C. Misare [et al] // J. Vasc. Surg. - 1996. - № 24 (1). - Р 6-15.
33. Mori, H. Extensive arterial calcification of unknown etiology in a 29-year-old male / H. Mori [et al] // Heart. Vessel. - 1992. - № 7. - Р. 211-214.
34. Pacifici, R. Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis / R. Pacifici // J. Bone. Miner. Res. - 1996. - № 11. - Р. 1043-1051.
35. Price, P. A. Bone origin of the serum complex of calcium, phosphate, fetuin, and matrix Gla protein: Biochemical evidence for the cancellous bone-remodeling compartment / P. A. Price // J. Bone. Miner. Res. - 2002. - № 17. - Р. 1171-1179.
36. Proudfoot, D. Biology of calcification in vascular cells: intima versus media / D. Proudfoot, C. M. Shanahan // Herz. - 2001. - № 26. - Р. 245-251.
37. Proudfoot, D. Apoptosis regulates human vascular calcification in vitro: Evidence for initiation of vascular calcification by apoptotic bodies / D. Proudfoot [et al] // Circ. Res. - 2000. - № 87. - Р. 1055-1062.
38. Rubin, J. R. Femoral-tibial bypassfor calcific arterial disease / J. R. Rubin [et al] // Am. J. Surg. - 1989. - № 158 (2). - Р. 146-150.
39. Sheridan, D. J. Left Ventricular Hypertrophy / D. J. Sheridan // Churchill Livingstone. - 1998.
40. Stary, H. C. An atlas of atherosclerosis progression and regression / H. C. Stary. - N.-Y.: Parthenon, 1999.
41. Stary, H. C. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association / H. C. Stary [et al] // Circulation. - 1995. - № 92. - Р. 1355-1374.
42. Taki, K. Oxidative stress, advanced glycation end product, and coronary artery calcification in hemodialysis patients / K. Taki [et al] // Kidney Int. - 2006. - № 70. - Р. 218-224.
43. Taniwaki, H. Aortic calcification in haemodialysis patients with diabetes mellitus / H. Taniwaki [et al] // Nephrol. Dial. Transplant. - 2005. - № 20. - Р. 2472-2478.
44. Tintut, Y. Recent advances in multifactorial regulation of vascular calcification / Y. Tintut, L. L. Demer // Curr. Opin. Lipidol. - 2001. - № 12 (5). - Р. 555-560.
45. Tonyz, R. M. Vascular smooth muscle cells sense calcium: a new paradigm in vascular calcification / R. M. Tonyz, A. C. Montezano // Cardiovasc. Research. - 2009. - № 81. - № 237-239.
46. Van Campenhout, A. Role of homocystein in aortic calcification and osteogenic cell differentiation / A. Van Campenhout [et al] // Atheroscler. - 2009. - № 202. - Р. 557-566.
47. Virchow, R. Cellular Pathology: As Based Upon Physiological and Pathological Histology / R. Virchow. - N.-Y.: Dover, 1971.
48. Wallin, R. Arterial calcification: a review of mechanisms, animal models, and the prospects for therapy / R. Wallin [et al] // Med. Res. Rev. - 2001. - № 21. - Р 274-301.
49. Yang, H. Elevated extracellular calcium levels induce smooth muscle cell matrix mineralization in vitro / H. Yang, G. Curinga, C. M. Giachelli // Kidney Int. - 2004. - № 66. Р. 2293-2299.
Review
For citations:
Melnikov M.V., Barsukov A.E., Zelinskiy V.A., Apresyan A.U. Aorta and major arteries calcinosis: pathobiological mechanisms and clinical significance. Regional blood circulation and microcirculation. 2012;11(2):4-10. (In Russ.) https://doi.org/10.24884/1682-6655-2012-11-2-4-10
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