Effects of drospirenone on the cardiovascular remodeling in experimental menopause
https://doi.org/10.24884/1682-6655-2012-11-2-47-51
Abstract
The article is devoted to the morphological characteristics of the cardiovascular remodeling in experimental menopause and effects of drospirenone on it. Drospirenone is a synthetic progesterone with antimineralicorthicoids activity. Most of the normotensive ovariectomized rats have developed eccentric left ventricular hypertrophy without arterial hypertension. Marked perivascular fibrosis was observed in myocardium as well. Drospirenone attenuates left ventricular hypertrophy and prevents process of the fibrosis, but these findings don't reach the control ones.
About the Authors
E. I. Baranova
The Saint Petersburg State Pavlov Medical University
Russian Federation
Russian Federation
O. O. Bolshakova
V. A. Almasov Federal Heart, Blood and Endocrinology Center
Russian Federation
Russian Federation
A. Y. Bagrov
National Institute on Aging, Baltimore
United States
United States
G. M. Nutfullina
The Saint Petersburg State Pavlov Medical University
Russian Federation
Russian Federation
I. A. Kuznetzova
The Saint Petersburg State Pavlov Medical University
Russian Federation
Russian Federation
S. M. Minasyan
V. A. Almasov Federal Heart, Blood and Endocrinology Center
Russian Federation
Russian Federation
T. H. Yusipova
The Saint Petersburg State Pavlov Medical University
Russian Federation
Russian Federation
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Review
For citations:
Baranova E.I., Bolshakova O.O., Bagrov A.Y., Nutfullina G.M., Kuznetzova I.A., Minasyan S.M., Yusipova T.H. Effects of drospirenone on the cardiovascular remodeling in experimental menopause. Regional blood circulation and microcirculation. 2012;11(2):47-51. (In Russ.) https://doi.org/10.24884/1682-6655-2012-11-2-47-51
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