Dynamics of the level of antibodies to NR2A-subunit NMDA-glutamate receptors at change of cerebral blood flow in the basin of the internal carotid artery
https://doi.org/10.24884/1682-6655-2013-12-4-24-29
Abstract
Examined 92 patients with hemodynamically significant stenosis of the internal carotid artery. All the patients underwent reconstructive surgery on the arteries of the neck, after which the dynamics were assessed level of autoantibodies to the NR2A-subunit of the NMDA-receptor. Used immunoassay method for semiquantitative determination of the level of antibodies to NR2A-subunit NMDA-receptors of glutamate. It is established that in the group of patients with low potential of structural and functional compensation of cerebral blood flow alteration NMDA-glutamate receptors prevailed. Deterioration of cerebral blood flow for the period after clamping the internal carotid artery during surgery is a factor objectively weighting degree of hypoxia in the affected vascular pool and amplifying the degree of alteration NMDA-glutamate receptors.
About the Authors
V. N. Ochkolyas
St. Petersburg Pavlov State Medical University
Russian Federation
Russian Federation
A. A. Skoromets
St. Petersburg Pavlov State Medical University
Russian Federation
Russian Federation
G. Yu. Sokurenko
The Federal State Institute of Public Health «The Nikiforov Russian Center of Emergency and Radiation Medicine»
Russian Federation
Russian Federation
References
1. Ворлоу Ч. П. и др. Инсульт: практическое руководство для ведения больных. СПб.: Политехника, 1998. 629 с.
2. Гайдар Б. В. и др. Ультразвуковые методы исследования в диагностике поражений ветвей дуги аорты: учеб. пособие. Петрозаводск, 1994. 71 с.
3. Гусев Е. И. Ишемическая болезнь головного мозга // Вестник РАМН. 1993. № 7. С. 34-39.
4. Дамбинова С. А. Нейрорецепторы глутамата. Л.: Наука, 1989. 279 с.
5. Пат. 2146826 Российская Федерация, МПК 7G01N33/68C07K2/00, C07K14/705, C07K16/28, C07K17/00, G01N33/535, G01N33/53, A61K39/00. Диагностический набор реагентов "CIS-тест" для выявления ишемической болезни головного мозга млекопитающих / Дамбинова С.А.; заявитель и патентообладатель Дамбинова С. А. № 98107477/13; заявл. 24.04.1998; опубл. 20.03.2000. Бюл. № 16.
6. Astrup J. et al. Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia // Stroke. 1977. Vol. 8 (1). P. 51-57.
7. Chevalier J. M. et al. Reverse endarterectomy of the internal carotid // J. Mal. Vasc. 1994. Vol. 19. Suppl. A. P. 18-23.
8. Haddad G. G., Jiang C. O2 deprivation in the central nervous system: on mechanisms of neuronal response, differential sensitivity and injury // Prog. Neurobiol. 1993. Vol. 40. Р. 277-318.
9. Hegstad E. et al. Aminoacid release from human cerebral cortex during simulated ischaemia in vitro // Acta Neurochir (Wien). 1996. Vol. 138 (2). P. 234-241.
10. Obrenovitch T. P. et al. Excitotoxicity in neurological disorders the glutamate paradox / T. P. Obrenovitch // Int. J. Dev Neurosci. 2000. Vol. 18 (2-3). P 281-287.
11. Olney J. W. New mechanisms of excitatory transmitter neurotoxicity // J. Neural. Transm. Suppl. 1994. Vol. 43. P.47-51.
12. Olsen T. S. et al. Cause of cerebral infarction in the carotid territory: Its relations to the size and the location of the infarct and to the underlying vascular lesion // Stroke. 1985. № 16. P. 459-466.
13. Siesjo B. K., Bengtsson F. Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis // J. Cereb. Blood Flow. Metab. 1989. Vol. 9. P 127-140.
Review
For citations:
Ochkolyas V.N., Skoromets A.A., Sokurenko G.Yu. Dynamics of the level of antibodies to NR2A-subunit NMDA-glutamate receptors at change of cerebral blood flow in the basin of the internal carotid artery. Regional blood circulation and microcirculation. 2013;12(4):24-29. (In Russ.) https://doi.org/10.24884/1682-6655-2013-12-4-24-29
Views:
366
Email this article 
