Pathomorphological and biomechanical changes of the trunk of great saphenous vein at varicose veins

Abstract

139 patients with varicose veins of the lower extremities, complicated by chronic venous insufficiency C2-C4 (according to the CEAP classification), were examined. During phlebectomy the fragments of the great saphenous vein in the area of saphenofemoral fistula and in the region of the medial malleolus with subsequent histological study of biopsy material and evaluation of contractile activity of the venous walls in the physiological device Ugo Basile (Italy) were collected. It was found that all fragments of the great saphenous vein, regardless of the stage of CVI, possessed the spontaneous contractile activity (basal tone and phase reduction). However, the strength of the elastic strain and the amplitude of the phasic contractions were dependent on the integrity of the smooth muscle component of the venous wall and the severity of flebosclerosis.