The inhibitory effect of IL-1β on the contractile activity of smooth muscle capsule lymph nodes
https://doi.org/10.24884/1682-6655-2013-12-3-53-56
Abstract
Results of this investigation show that IL-1β (Betaleukin) has a direct inhibitory effect on the contractile function of the bovine lymph nodes. Relaxation responses of smooth muscle of capsule of lymph nodes on the action IL-1β at a concentration of 2.5x10-15 M to 2.5x10-10 M were dose-dependent manner and were manifested in the form of lower amplitude and phase frequency of contractile activity of smooth muscle and decrease of the tone. The inhibitory effects of IL-1β were significantly decrease after previous adding of aspirin, whereas the use of an inhibitor of nitric NO L-NAME is not prevented the relaxation responses initiated by the action of IL-1β. The obtained data suggest that the direct inhibitory effect of IL-1β on the contractile activity of smooth muscle capsule of lymph nodes is realized mainly by a prostaglandin-dependent pathway.
About the Authors
M. N. Pan'kova
Pavlov Institute of Physiology of the Circulatory System, Russian Academy of Sciences
Russian Federation
Russian Federation
G. I. Lobov
Pavlov Institute of Physiology of the Circulatory System, Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Pan'kova M.N., Lobov G.I. The inhibitory effect of IL-1β on the contractile activity of smooth muscle capsule lymph nodes. Regional blood circulation and microcirculation. 2013;12(3):53-56. (In Russ.) https://doi.org/10.24884/1682-6655-2013-12-3-53-56
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