Experimental research of the regional ophthalmic blood flow in normal conditions and by hyperglycemia
https://doi.org/10.24884/1682-6655-2012-11-4-66-70
Abstract
Using Color Doppler, Power Doppler and Impulse dopplerography we developed a scheme of the blood supply of rat's eye and studied principal parameters of the blood flow. We detected the peculiarity of the blood flow in rat's eye in the experimental model of streptozotocin-induced diabetes mellitus, the monitoring continued 12 months. The strongly pronounced changes were detected in inferior ophthalmic artery. Reduction of all blood flow parameters in central retinal artery, central retinal vein and posterior long ciliary arteries was detected. Increasing of the resistance index during the whole research period was registered. The findings indicate a beginning of hemodynamic malfunction before the clinical signs of retinal lesion by the rats with hyperglycemia.
About the Authors
V. V. Neroev
The Helmholtz Moscow Research Institute of Eye Diseases
Russian Federation
Russian Federation
T. N. Kiseleva
The Helmholtz Moscow Research Institute of Eye Diseases
Russian Federation
Russian Federation
M. V. Ryabina
The Helmholtz Moscow Research Institute of Eye Diseases
Russian Federation
Russian Federation
T. D. Okhotsimskaya
The Helmholtz Moscow Research Institute of Eye Diseases
Russian Federation
Russian Federation
O. V. Zolotykh
The Helmholtz Moscow Research Institute of Eye Diseases
Russian Federation
Russian Federation
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Review
For citations:
Neroev V.V., Kiseleva T.N., Ryabina M.V., Okhotsimskaya T.D., Zolotykh O.V. Experimental research of the regional ophthalmic blood flow in normal conditions and by hyperglycemia. Regional blood circulation and microcirculation. 2012;11(4):66-70. (In Russ.) https://doi.org/10.24884/1682-6655-2012-11-4-66-70
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