MicroRNA as biomarkers of myocardial ischemic injury: a perspective
https://doi.org/10.24884/1682-6655-2012-11-3-69-75
Abstract
Over the past few years, it has become evident that microRNA is involved in the regulation of cardiovascular function. The continuous refinement of the techniques of microRNA purification and analysis has allowed the identification of these molecules not only in the cells, but also in the different biological fluids. Despite the fact that the mechanisms of microRNA release into the biological fluids as well as the functions of extracellular microRNA remain largely unexplored, the number of publications on the use of circulating microRNAs as biomarkers of various pathological processes is increasing. In this review, we discuss the methods of quantitative determination of circulating microRNA and summarize recent data on increased levels of certain microRNAs in the blood in response to myocardial ischemia.
About the Authors
A. V. Fedorov
V. A. Almazov Federal Center of Heart, Blood and Endocrinology
Russian Federation
Russian Federation
A. A. Kostareva
V. A. Almazov Federal Center of Heart, Blood and Endocrinology; I. P. Pavlov State Medical University
Russian Federation
Russian Federation
M. M. Galagudza
V. A. Almazov Federal Center of Heart, Blood and Endocrinology; I. P. Pavlov State Medical University
Russian Federation
Russian Federation
S. M. Minasyan
V. A. Almazov Federal Center of Heart, Blood and Endocrinology; I. P. Pavlov State Medical University
Russian Federation
Russian Federation
D. I. Kurapeev
V. A. Almazov Federal Center of Heart, Blood and Endocrinology
Russian Federation
Russian Federation
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Review
For citations:
Fedorov A.V., Kostareva A.A., Galagudza M.M., Minasyan S.M., Kurapeev D.I. MicroRNA as biomarkers of myocardial ischemic injury: a perspective. Regional blood circulation and microcirculation. 2012;11(3):69-75. (In Russ.) https://doi.org/10.24884/1682-6655-2012-11-3-69-75
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