Correlation of morphological and functional indices in ocular blood flow assessment

Introduction. Approximately 80-90 % of circulating ocular blood is concentrated in the choroid. Pathological changes in choroidal blood vessels could be found in many posterior diseases of the posterior segment of the eye. Purpose. To measure choroidal thickness in healthy subjects in different age and refraction. To assess the correlation between choroidal thickness in macular area and ophthalmoplethysmography, ophthalmoreography, sphygmography indices in normal subjects. Materials and methods. To assess age and refraction influence on the choroidal thickness 149 healthy probands (258 eyes) were examined. To assess correlation between choroidal thickness and ophthalmoplethysmography, ophthalmoreography, sphygmography indices a group of 30 subjects (60 eyes) without any ocular disease were recruited. Choroidal thickness was measured on Spectralis OCT (Heidelberg Engineering, Germany) in enhanced depth imaging regime. Results. Negative correlation between choroidal thickness and age (r = -0.78, p < 0.0001), and degree of myopia (r = -0.75, p < 0.0001) were found. In all examined subjects positive correlations between choroidal thickness in the zone corresponding to the retinal avascular area and systolic increase of pulse volume according to ophthalmoplethysmography, ophthalmoreography, sphygmography data as well as between choroidal thickness at the central line near the optic nerve head (ONH) and amplitudes of ophthalmoreography were found. Conclusions. Significant mild and moderate positive and negative correlations were found between studied haemodynamic indices (investigated by different methods) and choroidal thickness. Ophthalmoplethysmography, ophthalmoreography, sphygmography indices are influenced by biometric eyeball parameters and the choroid. That is why it is necessary to take into account these parameters in consideration when interpreting and calculating measurement results.

хориоидея, толщина хориоидеи, офтальмоплетизмография, офтальмореография, сфигмография, глазной кровоток, оптическая когерентная томография, choroid, choroidal thickness, ophthalmoplethysmography, ophthalmoreography, sphygmography, ocular blood flow, optical coherence tomography

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